Author System Drug CL Predicted CL Observed Fold Difference BDDCS Class

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Nadzieja Jarosz
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1 Hepatic clearance predictions from in vitro-in vivo extrapolation and BDDCS Christine M. Bowman, Leslie Z. Benet Drug Metabolism and Disposition Supplementary Table 1: Compiled IVIVE predictions and BDDCS classifications Author System Drug CL Predicted CL Observed Fold Difference BDDCS Class f ub Brown et al. Hepatocytes Furosemide (2007) Ketoprofen Mephenytoin Timolol Metoprolol Lorazepam Tolbutamide Gemfibrozil Propranolol Terfenadine Dextromethorphan Naproxen Imipramine Lidocaine Ibuprofen Diltiazem Triazolam Diclofenac Oxazepam

2 Flunitrazepam Nifedipine Quinidine S-Warfarin Diazepam Desipramine Bufuralol Propofol Alprazolam Midazolam Chlorpromazine Methylprednisolone Antipyrine Caffeine Prednisolone Theophylline Naloxone Codeine Hallifax et al. Microsomes Prochlorperazine (2010) Theophylline Felodipine Mianserin FK Amitriptyline Clozapine Propranolol Mexiletine Lidocaine Methoxsalen

3 Promazine Phenytoin Labetalol Ondansetron Imipramine Promethazine Lorcainide Phenacetin Dofetilide Quinidine Warfarin Indinavir Prednisone Omeprazole Desipramine Ibuprofen Nilvadipine FK Glyburide Caffeine Trimipramine Buprenorphine Clomipramine Fluphenazine Dexamethasone Ketamine Antipyrine Diclofenac Methohexital Diltiazem

4 Metoprolol Fenoprofen Flunitrazepam Propafenone Alprenolol Tolbutamide Chlorpheniramine Gemfibrosil Tenoxicam Verapamil Bepridil Nicardipine Amobarbital Diazepam Zolpidem Chlorpromazine Bupivacaine Tenidap Alprazolam Risperidone YW Sildenafil Triazolam Domperidone Trazodone Midazolam Glimepiride Hallifax et al. Hepatocytes Prochlorperazine (2010) Furosemide

5 Buprenorphine Mianserin Fluoxetine Levoprotiline Labetalol Promazine Fluphenazine Glyburide Phenacetin Montelukast Lorazepam Promethazine Metoprolol Cyclosporin A Flumazenil Timolol Trimipramine Clomipramine Verapamil Propranolol Temazepam Diltiazem Ondansetron Clozapine Imipramine Tolbutamide Glipizide Ketoprofen Prazosin Diphenhydramine

6 Oxazepam Lidocaine Diclofenac Bepridil Indomethacin Propafenone Naproxen Oxaprozin Zolpidem Sildenafil Diflunisal Ketamine Bupivacaine Triprolidine Domperidone Ritonavir Flunitrazepam Morphine Gemfibrosil Desipramine Acetaminophen Triazolam Diazepam Irbesartan Quinidine Trazodone Alprenolol Ibuprofen Carvedilol

7 Oxprenolol S-Warfarin Chlorpromazine Ranitidine Bufuralol Methylprednisolone Scopolamine Caffeine Nifedipine Fenoprofen Cimetidine Pindolol Metoclopramide Betaxolol Granisetron Acebutolol Theophylline Alprazolam Midazolam Prednisolone Antipyrine Etodolac Glimepiride Codeine Chlorpheniramine Nadolol Tenoxicam Carbamazepine Ito et al. Microsomes Theophylline

8 (2005) Felodipine FK Amitriptyline r-warfarin Mexiletine Methoxsalen Diphenhydramine Phenytoin Propafenone Ketamine Ondansetron Diclofenac Lidocaine Imipramine Chlorpromazine Verapamil Lorcainide Clozapine Dofetilide Tenidap Ibuprofen Desipramine Warfarin Caffeine Indinavir Prednisone Zolpidem Omeprazole Nilvadipine Quinidine

9 FK Midazolam s-warfarin Dexamethasone Methohexital Propranolol Hexobarbital Diltiazem Antipyrine Diazepam Triazolam Phenacetin Flunitrazepam Diazepam Tolbutamide Nicardipine Amobarbital Alprazolam Metoprolol Tenoxicam YW McGinnity et al. Hepatocytes Imipramine (2004) Fluoxetine Desipramine Propranolol Morphine Omeprazole Ondansetron Metoprolol

10 Zileuton Doxepin Bepridil Ranitidine Verapamil Scopolamine Diltiazem Diphenhydramine Cimetidine Triprolidine Triazolam Acebutolol Granisetron Nifedipine Clozapine Betaxolol Pindolol Cyclosporin A Bromocriptine Prazosin Diazepam Dextromethorphan Lorazepam Ethinylestradiol Bisoprolol Isradipine Midazolam Caffeine Temazepam Ritonavir

11 Codeine Chlorpheniramine Carvedilol Propofol Carbamazepine Naloxone Obach et al. Microsomes Zolpidem (1999) (fu b and fu inc ) Ibuprofen Tolbutamide Diclofenac Diphenhydramine Warfarin Methoxsalen Dexamethasone Tenidap Diltiazem Diazepam Amitriptyline Hexobarbital Quinidine Imipramine Lorcainide Clozapine Propafenone Verapamil Methohexital Prednisone Triazolam Desipramine

12 Ketamine Chlorpromazine Amobarbital Tenoxicam Midazolam Alprazolam Obach et al. Microsomes Zolpidem (1999) (fu b ) Amitriptyline Diazepam Diphenhydramine Tenidap Clozapine Warfarin Ibuprofen Imipramine Chlorpromazine Prednisone Quinidine Tolbutamide Diclofenac Desipramine Methoxsalen Diltiazem Dexamethasone Hexobarbital Propafenone Lorcainide Verapamil Triazolam

13 Ketamine Methohexital Tenoxicam Amobarbital Alprazolam Midazolam Obach et al. Microsomes Diphenhydramine (1999) (no binding) Zolpidem Prednisone Hexobarbital Ketamine Amitriptyline Dexamethasone Diltiazem Methoxsalen Desipramine Imipramine Lorcainide Methohexital Verapamil Propafenone Chlorpromazine Quinidine Clozapine Alprazolam Triazolam Midazolam Tolbutamide Diclofenac

14 Amobarbital Diazepam Ibuprofen Warfarin Tenidap Tenoxicam Riley et al. Microsomes Methoxsalen (2005) Phenacetin Propranolol Fluvastatin Propafenone Lorcainide Diclofenac FK Ibuprofen Phenytoin Diphenhydramine Zolpidem Amitriptyline Omeprazole Tolbutamide Dexamethasone Methohexital Imipramine Tenidap Diltiazem Metoprolol Hexobarbital

15 Diazepam Nilvadipine Quinidine Desipramine Verapamil Chlorpromazine Clozapine Prednisone Triazolam Amobarbital Tenoxicam Midazolam Alprazolam FK Nicardipine Riley et al. Hepatocytes FK (2005) Troglitazone Montelukast Cyclosporin A FK Lorazepam Sildenafil Glipizide Nifedipine Prazosin FK Naloxone Midazolam Indomethacin

16 Propranolol Diazepam Oxazepam Ketoprofen Zidovudine Oxaprozin Lidocaine Furosemide Fenoprofen Quinidine Diflunisal Timolol Diclofenac Triprolidine Metoprolol Ritonavir Phenacetin Acetaminophen Buspirone Gemfibrozil Ondansetron Irbesartan Warfarin Chlorpromazine Carvedilol Diltiazem Prednisolone Ranitidine Methylprednisolone Verapamil

17 Imipramine Tolbutamide Cimetidine Granisetron Ibuprofen Etodolac Theophylline Desipramine Antipyrine Caffeine Pindolol Tenoxicam Riley et al. Hepatocytes Tolcapone (2005) (serum) Mibefradil Felodipine Bosentan Diltiazem Oxazepam Midazolam Propranolol Warfarin Lorazepam Diazepam Theophylline Caffeine Antipyrine

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