Ewa Widy Tyszkiewicz

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1 Curriculum vitae PERSONAL INFORMATION Ewa Widy Tyszkiewicz WORK EXPERIENCE 1966 Present Associate Professor 1966 Research and teaching in pharmacology for students of the Medical Faculty of Medical University of Warsaw 1995 Associate Professor, Department of Experimental and Clinical Pharmacology Medical University of Warsaw 1995 Research and teaching in pharmacology for students of the English Division of Medical University of Warsaw (Head of Administrative Procedures) 1995 Expert for pharmaceutical industry : Member of the Committee on Herbal Medicinal Products in the Office for Registration of Medicinal Products, Medical Devices and Biocidal Products, Warsaw : President of the Warsaw Branch of the Polish Pharmacological Society : President of the Committee for Dietary Supplements in the Office for Registration of Medicinal Products, Medical Devices and Biocidal Products, Warsaw Head of the research team and the Laboratory of Behavioral Pharmacology and Natural Products at the Department of Experimental and Clinical Pharmacology Medical University of Warsaw EDUCATION AND TRAINING 1966 Present M.D. Medical Faculty of Warsaw Medical University 1972 Present Ph.D. Medical Faculty of Warsaw Medical University: Pharmacological features and mechanism of action of pirydylmethylamides of acetyltropic acid 1995 Present D.Sc. Habilitation in pharmacology, Medical Faculty of Warsaw Medical University.: Role of opioid system in experimental hypertension in rats ADDITIONAL INFORMATION Expertise Experimental pharmacology and toxicology Neuropharmacology Herbal medicines Publications Selected publications K. Kądzielawa, E. Widy-Tyszkiewicz. Potentiation by desmethylimipramine of ganglionic inhibition by catecholamines. Arch. Int. Pharmacodyn. 1969, 180, K. Kądzielawa, E. Widy-Tyszkiewicz. The influence of various pharmacological agents on the desynchronization produced by DOPA in the cerveau isole"preparation. Electrenceph. Clin. Neurophysiol. 1970, 28, K. Kądzielawa, E. Widy. The influence of imipramine on the central effects effects of dihydroxyphenylalanine. Neuropharmacology 1970, 9, /11/17 European Union, Page 1 / 5

2 E. Widy-Tyszkiewicz, T. L Sourkes. N-Pentylamine: effect on motor activity of mice. Pharm. Biochem. Behav. 1980, 13, D. Ramirez-Gonzalez, E. Widy-Tyszkiewicz, T. L. Sourkes, G. Almazan. Effect of oxotremorine on ornithine decarboxylase activity of the adrenal gland in rat. Int. J. Neurochemistry 1980, 35, E. Widy-Tyszkiewicz, A. Członkowski. Analgesic activity of morphiceptin, beta-casomorphin-4 and deltakephalin in normotensive Wistar Albino-Glaxo and spontaneousły hypertensive rats. Peptides 1989, 10, E. Widy-Tyszkiewicz, A. Członkowski. Normotensive Wistar rats differ from spontaneousły hypertensive and renal hypertensive rats in their cardiovascular responses to opioid agonists. Clin. Exp. Pharmacol. Physiol. 1991, 8, E. Widy-Tyszkiewicz, J. Scheel-Kruger, A. V. Christensen. Enhanced disruptive spatial learning effect after sufentanil in renal hypertensive rats versus normotensive rats. Physiol. Behav. 1993, 53, E. Widy-Tyszkiewicz, J. Scheel-Kruger, A. V. Christensen. Spatial navigation learning in spontaneousły hyprtensive, renal hypertensive and normotensive Wistar rats. Behav. Brain Res. 1993, 54, E. Widy-Tyszkiewicz, A. V. Christensen. Memory impairment with pretreatment but not with posttreatment of quaternary naloxone. Pharmacol. Toxicol. 1994,74, E. Widy-Tyszkiewicz. Cholinergic Drugs. l Cholinomimetics. In: Pharmacology. Textbook for medical students and doctors, edited by W. Kostowski, PZWL Warsaw, 1998, 2001, E. Widy-Tyszkiewicz. Cholinergic Drugs II. Anticholinergic drugs, ibid, E. Widy-Tyszkiewicz. Drugs and autonomic Ganglia, ibid, E. Widy-Tyszkiewicz. Drugs affecting skeletal muscle and neuromuscular transduction, ibid, E. Widy-Tyszkiewicz. Psychotropic drugs. In: Drug therapy during pregnancy, edited by K. Kmieciak- Kolada and J. Tomala PZWL, Warsaw 1998, Widy-Tyszkiewicz E., Piechal A.: Tellurium - induced cognitive deficits in rats are related to neuropathological changes in the central nervous system. Toxicol. Lett. 2002; 131: E. Widy-Tyszkiewicz., Piechal A., Joniec l., Blecharz-Klin K. Long term administration of Hypericum perforatum improves spatial learning and memory in the water maze. Biol. Pharm. BulI. 2002; 25, Widy-Tyszkiewicz E. Are we threaten by neurotoxic effects of manganese?. Polish Review of Cardiology 2002; 5 (Suppl 1): Piechal. A., Widy-Tyszkiewicz E. Zinc. The importance of clinical signs of deficiency. Medicine after Graduation, 2003, 12 (6): Widy-Tyszkiewicz E. Drug-induced cognitive impairment. In: Dementia, edited by A. Szczudlik, PP. Liberski, M. Barcikowska, Jagiellonian University Press, Kraków 2004, Widy-Tyszkiewicz E. Cognitive dysfunction induced by toxic agents. In: Dementia, edited by A. Szczudlik, PP. Liberski, M. Barcikowska, Jagiellonian University Press, Kraków 2004, Piechal A, Widy-Tyszkiewicz E. The role of zinc in the function of the immune system, In: Immunomodulation - New Opportunities in Health Care. Edited by AK Siwicki, E. Skopińska Rozewska, F.Świderski, Warsaw 2004, Blecharz-Klin K., Piechal A., Widy-Tyszkiewicz E. Ginger (Zingiber officinale) in modern therapy. Guide for General Practitioner. 2004, 5 (65) : Piechal A., Blecharz-Klin K., Widy-Tyszkiewicz E. Horse chestnut (Aesculus hippocastani) in modern therapy. Guide for General Practitioner. 2005, 4 (76): Widy-Tyszkiewicz E. Effect of flavonoids on cognition. Polish Review of Cardiology 2005; 7, Supplement 1: Blecharz-Klin K, Piechal A, Pyrzanowska J, Widy-Tyszkiewicz E. Interactions of herbal medicines used in respiratory system diseases. Herba Polonica 2005, 51: Blecharz-Klin K., Widy-Tyszkiewicz E. Neuroprotective mechanisms of action of ginkgo biloba (Ginkgo biloba). Polish Review of Cardiology 2006; 8, Suppl. 1: Szyndler J, Piechal A, Blecharz-Klin K, Skórzewska A, Maciejak P, Walkowiak J, Turzyńska D, Bidziński A, Płaźnik A, Widy-Tyszkiewicz E. Effect of kindled seizures on rat behavior in water Morris maze test and amino acid concentrations in brain structures. Pharmacological Reports 2006; 58: /11/17 European Union, Page 2 / 5

3 Pyrzanowska J., Piechal A., Blecharz-Klin K., Widy-Tyszkiewicz E. Interactions of herbal medicines used in gastrointestinal diseases. Herba Polonica 2006, 52 (1/2): Różański M, Widy-Tyszkiewicz E. Clinical evaluation of herbal medicinal products according to the criteria of evidence based medicine research. Polish Review of Cardiology 2007; 9: Suppl. 1: Piechal A., Blecharz-Klin K., Widy-Tyszkiewicz E. Horse chestnut (Aesculus hippocastanum) therapeutic relevance. Drug in Poland, 2007, 17 (229) : Pyrzanowska J., Piechal A., Blecharz-Klin K., Widy-Tyszkiewicz E.: The influence of long term administration of diferuloylmethane (CPE-014) on learning and spatial memory in the water maze in aged male rats. Pharmacological Reports, 2007; 59, Suppl. 1, 34. Pyrzanowska J. D., Piechal A., Blecharz-Klin K., Gutowicz M., Barańczyk-Kuźma A., Widy- Tyszkiewicz E. The influence of long term administration of diferuloylmethane (CPE-014) on explorative and motor activity in the hole-board in aged male rats, Pharmacological Reports, 2007, 59(1), 35. Różański M, Widy-Tyszkiewicz E. Risks arising from the use of dietary supplements of plant origin. Polish Review of Cardiology, 2008, 10: Suppl. 1:49-52 Blecharz-Klin K., Piechal A., Widy-Tyszkiewicz E. Ginger (Zingiber officinale) - Therapeutic relevance. Drug in Poland, 2008, 18 (207): Blecharz-Klin K., Uhrynowska-Tyszkiewicz I., Widy-Tyszkiewicz E. Glucosamine - Therapeutic relevance. Drug in Poland, 2008; 18(212): Gutowicz M., Chołojczyk M., Perzanowska J., Widy-Tyszkiewicz E., Barańczyk-Kuźma A., Effect of curcumin on detoxification and antioxidant mechanisms in the rat liver during aging, Veterinary Medicine, 2008, 64 (7), Blecharz-Klin K, Piechal A, Pyrzanowska, Joniec I, J, Widy-Tyszkiewicz E Pharmacological and biochemical effects of Ginkgo biloba extract on learning, memory consolidation and motor activity in old rats. Acta Neurobiologiae Experimentalis, 2009, 69: Blecharz-Klin K, Piechal A, Pyrzanowska, J, Widy-Tyszkiewicz E, Pygeum africanum in modern therapy. Drug in Poland, 2010, 20: Pyrzanowska J, Piechal A, Blecharz-Klin K, Lehner M, Skórzewska A, Turzyńska D, Sobolewska A, Plaznik A, Widy-Tyszkiewicz, E. The influence of the long-term administration of Curcuma longa extract on learning and spatial memory as well as the concentration of brain neurotransmitters and level of plasma corticosterone in aged rats. Pharm. Biochem. Behav., 2010; 95: Piechal A, Blecharz-Klin K, JPyrzanowska J, Widy-Tyszkiewicz E. Maternal Zinc Supplementation Improves Spatial Memory in Rat Pups. Biol Trace Elem Res. 2012; 147(1-3): Piechal A, Blecharz-Klin K, Wyszogrodzka E, Kołomańska P, Rok-Bujko P, Krząścik P, Filip M, Stefański R, Kostowski W, Widy-Tyszkiewicz E. Neonatal serotonin (5-HT) depletion does not affect spatial learning and memory in rats. Pharmacological Reports, 2012; 64(2): Pyrzanowska J, Piechal A, Blecharz-Klin K, Joniec-Maciejak I, Zobel A, Widy-Tyszkiewicz E. Influence of long-term administration of rutin on spatial memory as well as the concentration of brain neurotransmitters in aged rats. Pharmacological Reports 2012; 64(4): Blecharz-Klin K, Piechal A, Joniec-Maciejak I, Pyrzanowska J, Widy- Tyszkiewicz E. Effect of intranasal manganese administration on neurotransmission and spatial learning in rats. Toxicol Appl Pharmacol. 2012; 265:1-9. Kurkowska-Jastrzębska I, Swiątkiewicz M, Zaremba M, Cudna A, Piechal A, Pyrzanowska J, Widy- Tyszkiewicz E, Członkowska A. Neurodegeneration and inflammation in hippocampus in experimental autoimmune encephalomyelitis induced in rats by one - Time administration of encephalitogenic T cells. Neuroscience. 2013;248: Blecharz-Klin K, Piechal A, Pyrzanowska J, Joniec-Maciejak I, Kiliszek P, WidyTyszkiewicz E. Paracetamol-The outcome on neurotransmission and spatial learning in rats. Behav Brain Res. 2013; 253: Blecharz-Klin K, Joniec-Maciejak I, Piechal A, Pyrzanowska J, Wawer A, Widy-Tyszkiewicz E. Paracetamol impairs the profile of amino acids in the rat brain. Environ Toxicol Pharmacol. 2014; 37 (1): Widy-Tyszkiewicz E. Herbal medicines used for weight loss side effects. Medycyna po Dyplomie 2014; 23(2): Widy-Tyszkiewicz E. Selected dietary supplements used by patients with multiple sclerosis. MS Report 2014; 3: 2(9): /11/17 European Union, Page 3 / 5

4 Pyrzanowska J, Piechal A, Blecharz-Klin K, Joniec-Maciejak I, Graikou K, Chinou I, Widy- Tyszkiewicz E. Long-term administration of Greek Royal Jelly improves spatial memory and influences the concentration of brain neurotransmitters in naturally aged Wistar male rats. J Ethnopharmacol. 2014; 155 (1): Blecharz-Klin K, Agnieszka Piechal, Pyrzanowska J, Wirth-Dzięciołowska E, Widy- Tyszkiewicz E. Mice lines divergently selected for body mass show significant differences in spatial learning. Polish J Nat Sci 2015; 30(1):21-34 Matławska I, Bylka W, Widy-Tyszkiewicz E, Stanisz B. Determination of the juglone content of Juglans regia leaves by GC/MS. Nat Prod Commun 2015; 10(7): Blecharz-Klin K, Joniec-Maciejak I, Jawna K, Pyrzanowska J, Piechal A, Wawer A, Widy- Tyszkiewicz E. Developmental exposure to paracetamol causes biochemical alterations in medulla oblongata. Environ Toxicol Pharmacol 2015 (40): Widy-Tyszkiewicz E. Produkty roślinne w ciąży. Medycyna po Dyplomie 2015; 24(6): Blecharz-Klin K, Joniec-Maciejak I, Jawna K, Pyrzanowska J, Piechal A, Wawer A, Widy- Tyszkiewicz E. Effect of prenatal and early life paracetamol exposure on the level of neurotransmitters in rats focus on the spinal cord. Int J Devl Neuroscience 2015: Pyrzanowska J, Piechal A, Blecharz-Klin K, Joniec-Maciejak I, Graikou K, Chinou J, Widy- Tyszkiewicz E. Administration of Greek Royal Jelly produces fast response in neurotransmission of aged Wistar male rats. JPCCR 2015; 9(2): Widy-Tyszkiewicz E. Herbal medicines in pregnancy. Medycyna po Dyplomie 2015; 24(6): Piechal A, Blecharz-Klin K, Pyrzanowska J, Widy-Tyszkiewicz E. Influence of Long-Term Zinc Administration on Spatial Learning and Exploratory Activity in Rats. Biol Trace Elem Res 2016; 172: Kowalik M, Pyrzanowska J, Piechal A, Blecharz-Klin K, Widy-Tyszkiewicz E, Obszański M, Suprynowicz K, Pyrzanowski P. Determination of Mechanical Properties of Rat Aorta Using Ring- Shaped Specimen. Solid State Phenomena 2016 (240): Blecharz-Klin K, Joniec-Maciejak I, Jawna-Zboińska K, Pyrzanowska J, Piechal A, Wawer A, Widy- Tyszkiewicz E. Cerebellar level of neurotransmitters in rats exposed to paracetamol during development. Pharmacol Rep. 2016; 68(6): Widy-Tyszkiewicz E. Ophthalmic drugs in pregnancy. Okulistyka po Dyplomie 2016; 6 (4): Jawna K, Blecharz-Klin K, Joniec-Maciejak I, Wawer A, Pyrzanowska J, Piechal A, Mirowska-Guzel D, Widy-Tyszkiewicz E. Passiflora incarnata L. improves spatial memory, reduces stress, and affects neurotransmission in rats. Phytother Res 2016; 30 (5): Blecharz-Klin K. Jawna-Zboińska K, Piechal A, Pyrzanowska J, Wawer A, Joniec Maciejak I, Widy- Tyszkiewicz E. Paracetamol Effect of early exposure on neurotransmission, spatial memory and motor performance in rats. Behav Brain Res. 2017; 323: Krzysztoforska K, Mirowska-Guzel D, Widy-Tyszkiewicz E. Pharmacological effects of protocatechuic acid and its therapeutic potential in neurodegenerative diseases: Review on the basis of in vitro and in vivo studies in rodents and humans. Nutr Neurosci. 2017; Jul 26:1-11. doi: / X Tyszkiewicz J, Widy-Tyszkiewicz E. Adverse effects of non-steroidal anti-inflammatory drugs. Medycyna po Dyplomie 2017; 26(7-8): Projects Memberships Societies Polish Pharmacological Society (PTF) Member of EMA HMPC Working Party on Community Monographs and Community List Other Relevant Information Sabbatical leaves : Visiting Lecturer at Department of Neurochemistry of McGill University, Montreal, Canada Institute of Biological Psychiatry Sct Hans Hospital, Roskilde, Denmark 10/11/17 European Union, Page 4 / 5

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