Central Hospital of The Medical Univeristy of Warsaw, (Poland) Medical University of Warsaw, (Poland)

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1 Curriculum Vitae PERSONAL INFORMATION Maciej Kostrubiec WORK EXPERIENCE October 2001 October 2006 junior assistant Central Hospital of The Medical Univeristy of Warsaw, (Poland) May 2007 Present adjunct Medical University of Warsaw, (Poland) May 2007 Present assistant Jesus Infant Hospital, (Poland) January 2012 Present clonsultant/expert The Office for Registration of Medicinal Products, (Poland) September 2008 September 2011 consultant of the Board Polish Farmaceutical Holding, (Poland) EDUCATION AND TRAINING October 1994 September 2000 medical doctor Medical Univeristy of Warsaw, (Poland) October 2001 April 2005 PhD study Department of Internal Medicine, Hypertension and Angiology, The Medical University of Warsaw, (Poland) October 2001 September 2996 specialist in internal medicine Department of Internal Medicine, Hypertension and Angiology, The Medical University of Warsaw, (Poland) June 2007 April 2012 specialist in cardiology Department of Internal Medicine and Cardiology, Medical University of Warsaw, (Poland) May 2005 May 2013 habilitation Medical University of Warsaw, (Poland) European Union, Page 1 / 5

2 ADDITIONAL INFORMATION Expertise interanal medicine cardiology Publications 1. Wocial B. Berent H. Kuczyńska K. Kostrubiec M. Kuch-Wocial A. Niewęgłowska N. Homocysteine, adrenergic activity and left ventricular mass in patients with essential hypertension. Blood Press. 2002;11(4): (IF 02 = 1,344) 2. Pruszczyk P, Kostrubiec M, Bochowicz A, Styczynski G, Szulc M, Kurzyna M, Fijalkowska A, Kuch- Wocial A, Chlewicka I, Torbicki A. N-terminal pro-brain natriuretic peptide in patients with acute pulmonary embolism. Eur Respir J Oct; 22(4): (IF 03 = 2,999) 3. Pruszczyk P, Bochowicz A, Kostrubiec M, Torbicki A, Szulc M, Gurba H, Kuczynska K, Berent H. Myoglobin stratifies short-term risk in acute major pulmonary embolism. Clin Chim Acta Dec; 338(1-2): (IF 03 = 1,633) 4. Bochowicz A, Kostrubiec M, Pruszczyk P. Serum myoglobin in pulmonary embolism. Letter to the Editor. Circulation Apr 27;109(16):e194. (IF 04 = 12,563) 5. Pruszczyk P, Szulc M, Kostrubiec M. Potential clinical application of brain natriuretic peptides in acute pulmonary embolism. Letter to the Editor. Eur Heart J 2004 Apr;25(7):621. (IF 04 = 6,247) 6. Kuch-Wocial A, Ślubowska K, Kostrubiec M, Pasierski T, Januszewicz W, Świtalska H, Wocial B, Pruszczyk P. Plasma neuropeptide Y immunoreactivity influences left ventricular mass in pheochromocytoma. Clin Chim Acta 2004 Jul;345(1-2):43-7. (IF 04 = 1,961) 7. Kostrubiec M, Pruszczyk P, Bochowicz A, Pacho R, Szulc M, Kaczynska A, Styczynsk G, Kuch- Wocial A, Abramczyk P, Bartoszewicz Z, Berent H, Kuczynska K. Biomarker-based risk assessment model in acute pulmonary embolism. Eur Heart J 2005 Oct;26(20): Epub 2005 May 23 (IF 05 = 7,341) 8. Draminska A, Kuch-Wocial A, Szulc M, Zwolinska A, Styczynski G, Kostrubiec M, Hausmanowa- Petrusewicz I, Pruszczyk P. Echocardiographic assessment of left ventricular morphology and function in patients with Emery-Dreifuss muscular dystrophy. Int J Cardiol Jul 10;102(2): (IF 05 = 1,765) 9. Kostrubiec M, Kaczynska A, Pruszczyk P. Risk assessment in acute pulmonary embolism. Eur Heart J Jun;27(11):1384. (IF 06 = 7,286) 10. Kaczynska A, Pelsers MM, Bochowicz A, Kostrubiec M, Glatz JF, Pruszczyk P. Plasma heart-type fatty acid binding protein is superior to troponin and myoglobin for rapid risk stratification in acute pulmonary embolism. Clin Chim Acta Sep;371(1-2): (IF 06 = 2,328) 11. Kostrubiec M, Pruszczyk P, Kaczynska A, Kucher N. Persistent NT-proBNP elevation in acute pulmonary embolism predicts early death. Clin Chim Acta Jul;382(1-2): (IF 07= 2.601) 12. Kaczynska A, Szulc M, Styczynski G, Kostrubiec M, Pacho R, Pruszczyk P. Right ventricle injury during acute pulmonary embolism leads to its remodeling. Int J Cardiol Mar 28;125(1): Epub 2007 Apr 3 (IF 08 = 3,121) 13. Kaczyńska A, Kostrubiec M, Pacho R, Kunikowska J, Pruszczyk P. Elevated D-dimer concentration identifies patients with incomplete recanalization of pulmonary artery thromboemboli despite 6 months anticoagulation after the first episode of acute pulmonary embolism. Thromb Res. 2008;122(1):21-5. (IF 08= 2,449) 14. Kostrubiec M, Kaczynska A, Pruszczyk P. Right ventricle remodelling and elevated D-dimer concentration in patients 6 months after first episode of acute pulmonary embolism. Eur Heart J Aug;29(16): (IF 08 = 8,917) 15. Kaczyńska A, Kostrubiec M, Ciurzyński M, Pruszczyk P. B-type natriuretic peptide in acute pulmonary embolism. Clin Chim Acta Dec;398(1-2):1-4. (IF 08=2,960) 16. Kostrubiec M, Pedowska-Włoszek J, Ciurzyński M, Bienias P, Pacho S, Piaskowska M, Pruszczyk P. Endothelin is not elevated in acute pulmonary embolism. Thromb Res Jun;124(2): (IF 09= 2,406) 17. Kostrubiec M, Pruszczyk P. Endothelin and pulmonary embolism. Thromb Res Jul;126(1):e64 (IF 08= 2,372) 18. Kostrubiec M, Hrynkiewicz A, Pedowska-Włoszek J, Pacho S, Ciurzyński M, Jankowski K, Koczaj- Bremer M, Wojciechowski A, Pruszczyk P. Is it possible to use standard electrocardiography for risk assessment of patients with pulmonary embolism? Kardiol Pol Jul;67(7): (IF 09= European Union, Page 2 / 5

3 0,568) 19. Kostrubiec M, Labyk A, Pedowska-Wloszek J, Hrynkiewicz-Szymanska A, Jankowski K, Pacho S, Lichodziejewska B, Pruszczyk P. Mean Platelet Volume Predicts Early Death in Acute Pulmonary Embolism. Heart 2010;96: Published Online First: 11 November 2009 (IF 10= 4,708) 20. Kostrubiec M, Niewęgłowska N, Pruszczyk P. Prophylaxis of pulmonary embolism in pregnancy and puerperium. Ginekol Pol 2010; 81(01):46-49 (IF 10= 0,367) 21. Kostrubiec M, Niewegłowska N, Pruszczyk P. Diagnosis and treatment of pulmonary embolism in pregnancy. Ginekol Pol Apr;81(4): (IF 10= 0,367) 22. Kostrubiec M, Labyk A, Pedowska-Włoszek J, Pacho S, Wojciechowski A, Jankowski K, Ciurzyński M, Pruszczyk P. Assessment of renal dysfunction improves troponin-based short-term prognosis in patients with acute symptomatic pulmonary embolism. J Thromb Haemost. 2010;8: Published Online First: 2010 Jan 21. (IF 10= 5,439) 23. Jankowski K, Kostrubiec M, Ozdowska P, Milanowska-Puncewicz B, Pacho S, Pedowska- Włoszek J, Kaczyńska A, Labyk A, Hrynkiewicz A, Pruszczyk P. Electrocardiographic differentiation between acute pulmonary embolism and non-st elevation acute coronary syndromes at the bedside. Ann Noninvasive Electrocardiol Apr;15(2): (IF 10= 1,487) 24. Ciurzyński M, Bienias P, Irzyk K, Rymarczyk Z, Kostrubiec M, Szewczyk A, Glińska-Wielochowska M, Zyłkowska J, Kurzyna M, Pruszczyk P. Usefulness of echocardiography in the identification of an excessive increase in pulmonary arterial pressure in patients with systemic sclerosis. Kardiol Pol. 2011;69(1):9-15. (IF 11= 0,515) 25. Kostrubiec M. Znaczenie EKG w zatorowości płucnej. Kardiol Pol. 2011;69(9):939. (IF 11= 0,515) 26. Lankeit M, Jiménez D, Kostrubiec M, Dellas C, Hasenfuss G, Pruszczyk P, Konstantinides S. Predictive Value of the High-Sensitivity Troponin T Assay and the Simplified Pulmonary Embolism Severity Index in Hemodynamically Stable Patients With Acute Pulmonary Embolism: A Prospective Validation Study. Circulation Dec 13;124(24): (IF 11= 14,739) 27. Labyk A, Ciurzyński M, Jankowski K, Kostrubiec M, Lichodziejewska B, Bienias P, Pedowska- Włoszek J, Pacho S, Palczewski P, Pruszczyk P. Acute pulmonary embolism: analysis of consecutive 353 patients hospitalised in a single centre. A 3-year experience. Kardiol Pol. 2012;70(1): (IF 12= 0,536) 28. Kostrubiec M, Łabyk A, Pedowska-Włoszek J, Dzikowska-Diduch O, Wojciechowski A, Garlińska M, Ciurzyński M, Pruszczyk P. Neutrophil gelatinase-associated lipocalin, cystatin C and egfr indicate acute kidney injury and predict prognosis of patients with acute pulmonary embolism. Heart Aug;98(16): Epub 2012 Jun 15. (IF 12 = 5,014) 29. Kostrubiec M, Łabyk A, Pedowska-Włoszek J, Pacho S, Dzikowska-Diduch O, Dul P, Ciurzyński M, Bienias P, Pruszczyk P. Rapid improvement of renal function in patients with acute pulmonary embolism indicates favorable short term prognosis. Thromb Res Sep;130(3):e Epub 2012 Jun 16. (IF 12=3,133) 30. Irzyk K, Bienias P, Kostrubiec M, Rymarczyk Z, Bartoszewicz Z, Siwicka M, Stelmaszczyk-Emmel A, Górska E, Demkow U, Pruszczyk P, Ciurzyński M. Six-minute walk test reflects neurohormonal activation and right ventricular function in systemic sclerosis patients. Clin Exp Rheumatol Feb 13. [Epub ahead of print] (IF 12= 2,655) 31. Ciurzyński M, Bienias P, Irzyk K, Kostrubiec M, Bartoszewicz Z, Siwicka M, Kurzyna M, Demkow U, Pruszczyk P. Exaggerated increase of exercise-induced pulmonary artery pressure in systemic sclerosis patients predominantly results from left ventricular diastolic dysfunction. Clin Res Cardiol Jul 4 (IF'12=3,667) 32. Ciurzyński M, Bienias P, Irzyk K, Kostrubiec M, Bartoszewicz Z, Siwicka M, Stelmaszczyk-Emmel A, Górska E, Demkow U, Pruszczyk P. Serum endothelin-1 and NT-proBNP, but not ADMA, endoglin and TIMP-1 levels, reflect impaired right ventricular function in patients with systemic sclerosis. Clin Rheumatol Aug 14. (IF 12= 2,037) 33. Pedowska-Włoszek J, Kostrubiec M, Kurnicka K, Ciurzynski M, Palczewski P, Pruszczyk P. Midregional proadrenomedullin (MR-proADM) in the risk stratification of patients with acute pulmonary embolism. Thromb Res Aug 19. doi:pii: S (13) /j.thromres (IF 12=3,133) Summary impact factor IF = 119,173 Projects Projects of the Ministry of Science and High Education Grant KBN N N European Union, Page 3 / 5

4 Prospective assessment of influence of renal function on prognosis of patients with acute pulmonary embolism ; grant manager Grant KBN N N Assessment of endothelial function in idiopathic venous thromboembolism ; grant manager Grant KBN 2PO 5B Assessment of influence of right ventricle injury on its function in acute pulmonary embolism ; main investigator Projects of Medial University of Warsaw Statutory project Prognostic assessment of patients with acute pulmonary embolism ; main investigator Young investigator project Assessment of platelet activation in patients with acute pulmonary embolism ; grant manager Other scientific projects PEITHO study (prospective, randomized, double-blind, placebo-controlled, international, multicenter, parallel-group comparison trial evaluating the efficacy and safety of single i.v. bolus tenecteplase as compared with standard treatment in normotensive patients with acute pulmonary embolism and with echographic and laboratory evidence of right ventricular dysfunction), conducted due to investigators initiative and in cooperation with "Assistance Publique des Hopitaux de Paris" z Francji; ; investigator and co-organizer RIHTER study (prospective study on patients with pulmonary embolism and intracardiac thrombi) conducted due to investigators initiative, ; investigator and co-organizer Memberships from 2000 member of Polish Cardiac Society from 2000 member of European Cardiac Society from 2006 member of Club 30 of Polish Cardiac Society from 2006r investigator and co-organizer non-sponsored PEITHO study, conducted form investigators initiative and with cooperation with "Assistance Publique des Hopitaux de Paris" from France from 2007 member of Commission of Foreign Affairs of Polish Cardiac Society from 2007 member of Sport Cardiology Section of Polish Cardiac Society from 2010 member of Pulmonary Circulation Section of Polish Cardiac Society from 2012 member of Echocardiography Section of Polish Cardiac Society form 2012 member of Interventional Cardiology Association of Polish Cardiac Society from 2013 Fellow of European Society of Cardiology Other Relevant Information Awards: Ministry of Health: 2009 team scientific award of Ministry of Health for series of 4 publications on assessment of usefulness of biomarkers in prognosis of acute pulmonary embolism Rector of the Medical University of Warsaw nd degree individual scientific award of Rector of the Medical University of Warsaw nd degree team scientific award of Rector of the Medical University of Warsaw 2011 award of Commission for Promotion of Scientific Workers of the First Faculty of the Medical University of Warsaw for best result in ranking of scientific workers nd degree team scientific award of Rector of the Medical University of Warsaw rd degree team scientific award of Rector of the Medical University of Warsaw 2000 award of Rector of the Medical University of Warsaw for graduation of Medial University with very good results Other 2013 award of Presidents of Polish Cardiac Society for the studies on risk stratification in pulmonary embolism European Union, Page 4 / 5

5 2005 the first award in Aurelia Baczko Contest for the best PhD study in clinical medicine at the year 2005 European Union, Page 5 / 5