Goitre prevalence (%) Grade 1. Grade 2. TGP < >300 <100 Median Mean

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1 Vitamin and Mineral Nutrition Information System (VMNIS) WHO Global Database on Iodine Deficiency The database on iodine deficiency includes data by country on goitre prevalence and/or urinary iodine concentration Last Updated: Level Date Region and sample descriptor Sex Age (years) Sample size 1 Goitre prevalence (%) 2 Urinary iodine (µg/l) Distribution (%) Prevalence (%) TGP < >300 <100 Median Mean S 2005 Wielkpolska Region: SAC B a SAC by city: Poznań B SAC by city: Rychwal B SAC by city: Tuplice B SAC by city: Zydowo B L 2004P Seaside area: SAC B D Szczecin region: SAC B L Szczecin city: SAC B S 2000 Poznań: SAC B b Rychwal: SAC B Tuplice: SAC B Zydowo: SAC B L towns: SAC: Total B SAC by town: Bielsko-Biala B SAC by town: Czerwonka B SAC by town: Glincz B SAC by town: Jastrzebie B SAC by town: Krakow B SAC by town: Olsztyn B SAC by town: Poznan B SAC by town: Rychwald B SAC by town: Strumien B SAC by town: Tuplice B SAC by town: Tychy B SAC by town: Zydowo B L 1999 ThyroMobil study 8 sites: SAC: Total B a 1 SAC by site: Bobrek B SAC by site: Karpacz B SAC by site: Nowa Deba B SAC by site: Opoczno B SAC by site: Rudnik n/sanem B SAC by site: Rychwald B SD Reference Notes General Line

2 Vitamin and Mineral Nutrition Information System (VMNIS) WHO Global Database on Iodine Deficiency The database on iodine deficiency includes data by country on goitre prevalence and/or urinary iodine concentration Last Updated: Level Date Region and sample descriptor Sex Age (years) Sample size 1 Goitre prevalence (%) 2 Urinary iodine (µg/l) Distribution (%) Prevalence (%) TGP < >300 <100 Median Mean L 1999 SAC by site: Tomaszow Lubelski B a SAC by site: Zwierzyniec B SD Reference Notes General Line L SAC by site: Hel Peninsula B SAC by site: Karpacz B SAC by site: Lublin region B SAC by site: Olsztyn region B SAC by site: Opoczno B SAC by site: Rychwald B SAC by site: Tarnobrzeg region B SAC by site: Vistula River B L 1994 ThyroMobil study 3 sites: SAC B L 1994 ThyroMobil study 8 sites: SAC: Total B b 11 SAC by site: Bobrek B SAC by site: Karpacz B SAC by site: Nowa Deba B SAC by site: Opoczno B SAC by site: Rudnik n/sanem B SAC by site: Rychwald B SAC by site: Tomaszow Lubelski B SAC by site: Zwierzyniec B N SAC by geographic area: Bialystok plain B SAC by geographic area: Carpathian B SAC by geographic area: Lower upland and valley B SAC by geographic area: Poznan plain B SAC by geographic area: Seaside area B SAC by geographic area: Sudetes B SAC by geographic area: Upland B SAC by geographic area and sex: Bialystok plain F SAC by geographic area and sex: Bialystok plain M SAC by geographic area and sex: Carpathian F SAC by geographic area and sex: Carpathian M SAC by geographic area and sex: Lower upland a F SAC by geographic area and sex: Lower upland a M SAC by geographic area and sex: Poznan plain F

3 Vitamin and Mineral Nutrition Information System (VMNIS) WHO Global Database on Iodine Deficiency The database on iodine deficiency includes data by country on goitre prevalence and/or urinary iodine concentration Last Updated: Level Date Region and sample descriptor Sex Age (years) Sample size 1 Goitre prevalence (%) 2 Urinary iodine (µg/l) Distribution (%) Prevalence (%) TGP < >300 <100 Median Mean N SAC by geographic area and sex: Poznan plain M SAC by geographic area and sex: Seaside area F SAC by geographic area and sex: Seaside area M SAC by geographic area and sex: Sudetes F SAC by geographic area and sex: Sudetes M SAC by geographic area and sex: Upland F SAC by geographic area and sex: Upland M SD Reference Notes General Line S 1992 Wielkpolska region: SAC B c SAC by city: Poznań B SAC by city: Rychwal B SAC by city: Tuplice B SAC by city: Zydowo B

4 NOTES Reference no General Notes: 5615a Study designed to evaluate impact of iodine prophylaxis; children in 4 cities in Wielkpolska assessed prior to salt iodization (1992) and afterwards (2000, 2005); data extracted from English abstract and tables in publication. Reference no 5616 General Notes: Cross-sectional survey designed to assess goitre prevalence 3 years after the start of mandatory salt iodization (survey probably conducted in 2000 since mandatory salt iodization started in 1997, but survey year not provided); urinary iodine measured in a subsample; no description of sampling; data extracted from abstract in English. Reference no 5612 General Notes: Cross-sectional survey of randomly selected subjects from Szczecin region; data extracted from abstract in English. Reference no 5613 General Notes: Cross-sectional survey of subjects from Szczecin City; data extracted from abstract in English. Reference no 5615b General Notes: Study designed to evaluate impact of iodine prophylaxis; children in 4 cities in Wielkpolska assessed prior to salt iodization (1992) and afterwards (2000, 2005); data extracted from English abstract and tables in publication. Reference no 4028 General Notes: Thirteen schools in 12 towns included to assess the effect on iodine prophylaxis implemented in 1997; goitre investigated by ultrasonography, values not included in the database. Reference no 2574a General Notes: The ThyroMobil study in Poland carried out in 8 sites (primary schools) selected in goitrogenic areas not covered by the 1992/93 national survey; 8 sites representative for geographical and endemic features selected for a comparitative study carried out in 1994 (reference No. 2574b) and 1999 (reference No. 2574a). Line note 1 UI >60 µg/l: 70.0% Reference no 3336 General Notes: The ThyroMobil study in Poland covered 8 sites (18 schools); the sites with expected contrasting goitre incidence not covered by the 1992/93 national survey selected; goitre investigated by ultrasonography, values not included in the database. Line note 2 Survey described in detail in reference No Line note 3 Survey described in detail in reference No Line note 4 Survey described in detail in reference No Line note 5 Survey described in detail in reference No Line note 6 Survey described in detail in reference No Line note 7 Survey described in detail in reference No Line note 8 Survey described in detail in reference No Line note 9 Survey described in detail in reference No Reference no 1319 General Notes: The ThyroMobil study covered 3 sites; goitre investigated by ultrasonography, values not included in the database; data extracted from references No and 3384; this study is part of a more extensive survey reported in reference No Line note 10 UI median range: µg/l Reference no 2574b General Notes: The ThyroMobil study in Poland carried out in 8 sites (primary schools) selected in goitrogenic areas not covered by the 1992/93 national survey; 8 sites representative for geographical and endemic features selected for a comparitative study carried out in 1994 (reference No. 2574b) and 1999 (reference No. 2574a).

5 Line note 11 UI >60 µg/l: 44.0% Reference no 3231 General Notes: Random sample of 111 schools; survey presented in different references in two different ways, by geographic areas and coordinating centers; areas covered by coordinating centers do not correspond to geographic areas; data included in the database is presented by geographic areas; references No. 1735, 1875, 1874, 1873, 1872, 1871, 1870, 1869, 1868, 1737 and 1736 present the data by coordinating centers; reference No should be treated as the final summary of the national survey; disaggregated data by town available in the reference, but not reported in the database; prevalence of goitre investigated by ultrasonography, values not included in the database. Reference no 5615c General Notes: Study designed to evaluate impact of iodine prophylaxis; Children in 4 cities in Wielkpolska assessed prior to salt iodization (1992) and afterwards (2000, 2005); data extracted from English abstract and tables in publication.

6 Reference 1319 Reference 2574 Reference 3231 Reference 3336 Reference 4028 Reference 5612 Reference 5613 Reference 5615 Reference 5616 R E F E R E N C E S Delange F, Benker G, Caron P, Eber O, Ott W, Peter F, Podoba J, Simescu M, Szybinsky Z, Vertongen F, Vitti P, Wiersinga W, Zamrazil V. Thyroid volume and urinary iodine in European schoolchildren: standardization of values for assessment of iodine deficiency. European Journal of Endocrinology, 1997, 136 : Szybinski Z, Delange F, Lewinski A, Podoba J, Rybakowa M, Wasik R, Szewczyk L, Huszno B, Golkowski F, Przybylik-Mazurek E, Karbownik M, Zak T, Pantoflinski J, Trofimiuk M, Kinalska I. A programme of iodine supplementation using only iodised household salt is efficient-the case of Poland. European Journal of Endocrinology, 2001, 144 : Szybinksi Z. Data tables provided in relation to the National Survey [unpublished data]. Krakow, Jagiellonian University, Department of Endocrinology, Szybinski Z, Delange F, Lewinski A, Rybakowa M, Wasik R, Szewczyj L, Przybylik-Mazurek E, Dorant B, Karbownik M, Bandurska-Stankiewicz E. Regional differences in goitre incidence and urine iodine concentration among schoolchildren in Poland. Endokrynologia Polska, 1998, 49 (Suppl 1 (3)): Golkowski F, Huszno B, Trofimiuk M, Sowinski J, Bandurska-Stankiewicz E, Dorant B, Szybinski Z. Prevalence of goiter in schoolchildren - a study on the influence of adequate iodine prophylaxis in Poland. Journal of Endocrinological Investigation, 2003, 26 (2 Suppl): Kapil U, Singh P, Dwivedi SN. Status of iodine deficiency amongst school children in twenty four districts in southern India. Indian Journal of Physiology and Pharmacology, 2005, 49 : Brodowski J. Ocena stanu gospodarki jodowej I jej wplyw na budowe I czynnosc tarczycy u dzieci mlodziezy szczecinskiej po wprowadzeniu populacyjnego programu profilaktyki Jodowej [Iodine status and its influence on thyroid structure and function in children and teenagers after the introduction of an iodine prophylaxis programme in the city of Szczecin]. Annales Academiae Medicae Stetinensis, 2005, 51 : Baczyk M, Ruchala M, Pisarek M, Pietz L, Wrotkowska E, Wojewoda-Korbelak M, Dziubandowska A, Gembicki M, Sowinski J. Profilaktyka jodowa u dzieci w Regionie Wielkopolskim w latach [Iodine prophylaxis in children population on the Wielkopolska Region area from year 1992 to 2005.]. Endokrynologia Polska, 2006, 57 : Korpal-Szczyrska M, Dorant B, Kaminska H, Bitel L, Birkholz D, Kosiak W. Wplyw trzyletniej obowiazkowej profilaktyki jodowej na czestosc wyste powania wol a u dzieci szkolnych w regione nadmorskim Polski [Effect of three years obligatory iodine prophylaxis on the incidence of goiter in school children fron the seaside region of Poland]. Polski Merkuriusz Lekarski, 2004, 16 :41-43.

7 ADDITIONAL REFERENCES Reference 222 Reference 514 Reference 1735 Reference 1736 Reference 1737 Reference 1868 Reference 1869 Reference 1870 Reference 1871 Reference 1872 Reference 1873 Reference 1874 Reference 1875 Reference 1876 Gembicki M. Present status of iodine deficiency in Poland. In: Delange F et al., eds. Iodine deficiency in Europe. A continuing concern. New York, Plenum Press, 1993 : Gembecki M. Epidemiology and control of iodine deficiency disorders in Poland. IDD Newsletter, 1992, 8 : Szybinski Z, Zarnecki A. Prevalence of goiter, iodine deficiency and iodine prophylaxis in Poland: the results of a nationwide study. Endokrynologia Polska, 1993, 44 : Syrenicz A, Napierala K, Celibala R, Majewska U, Krzyzanowska B, Gulinska M, Gozdzik J, Widecka K, Czekalski S. Iodized salt consumption, urinary iodine concentration and prevalence of goiter in children from four districts of north-western Poland (Szczecin coordinating center). Endokrynologia Polska, 1993, 44 : Dorant B, Kaminska H, Korpal-Szczyrska M, Birkholz D, Kosiak W, Jakubowski Z, Bandurska-Stankiewicz E. Epidemiologic estimation of goiter in children from Gdansk, Elblag, Olsztyn and Torun districts (Gdansk coordinating center). Endokrynologia Polska, 1993, 44 : Gembicki M, Ruchala M, Bartkowiak M, Baczyk M, Junik R. The results of epidemiological studies concerning iodine deficiency and goiter in Poznan Region (Poznan coordinating center). Endokrynologia Polska, 1993, 44 : Szewczyk L, Ben-Skowronek I, Jaklinska T, Lozowski C. Studies on goiter occurrence and iodine deficiency in Lublin Upland (Lublin coordinating center). Endokrynologia Polska, 1993, 44 : Koehler B, Kozlowska A. Goiter incidence in region of Katowice in relation to iodine deficiency and iodine prophylaxis (Katowice coordinating center). Endokrynologia Polska, 1993, 44 : Kinalska I, Borawski J, Kretowski A, Szelachowska M, Poplawska A, Wysocka B. Iodine deficiency disorders in the north-eastern region of Poland (Bialystok coordinating center). Endokrynologia Polska, 1993, 44 : Bar-Andziak E, Lazecki D, Radwanowska N, Nauman J. Iodine intake and goiter incidence among schoolchildren living in Warsaw Region (Warsaw and Ciechanow Voivodships-Warsaw coordinating center). Endokrynologia Polska, 1993, 44 : Lewinski A, Tomaszewski W, Klencki M, Wajs E, Karbownik M, Slowinska-Klencka D, Skowronska-Jozwiak E, Bilinski P, Brzezinski J, Sewerynek E, Rybicka I, Kulak J, Kurowska S, Malolepsza A. Occurrence of goitre in relation to iodine deficiency in school children in Lodz City, the Lodz metropolitan area and in Piotrkow, Sieradz, Plock, Wloclawek, Radom and Skierniewice Voivodships (Lodz coordinating center). Endokrynologia Polska, 1993, 44 : Wasikowa R, Iwanicka Z, Zak T, Barg E, Basiak A, Bieniasz J, Kostecka L, Kotschy B, Maj A, Noczynska A, Sajewicz E, Wikiera B. Goiter prevalence in children in Lower and Middle Silesia (Wroclaw-coordinating center). Endokrynologia Polska, 1993, 44 : Rybakowa M, Tylek D, Ratajczak R, Anton A, Skalski M, Przybylik-Mazurek E, Huszno B, Golkowski F, Tarnawski A, Szybinski Z. Goiter incidence and urinary iodine excretion in children of age group 6-13 years living in south-eastern Poland (Krakow coordinating center). Endokrynologia Polska, 1993, 44 : Golkowski F, Szybinski Z, Huszno B, Stanuch H, Zarnecki A. Ultrasound measurement of thyroid volume in the nation-wide epidemiological survey on iodine deficiency in Poland. Endokrynologia Polska, 1993, 44 :

8 ADDITIONAL REFERENCES Reference 2521 Reference 2522 Reference 2524 Reference 2531 Reference 3365 Reference 3366 Reference 3367 Reference 3368 Reference 3369 Reference 3370 Reference 3371 Reference 4891 Reference 5386 Reference 5387 Szybinski Z, Sieradzki J, Huszno B, Tarnawski A, Korzeniowska D, Traczewska H. Wole u mlodziezy szkolnej na obszarze endemii Karpackiej [Goiter in school-children of the Carpathian endemic area]. Przeglad Lekarski, 1972, 29 : Januszko T, Karczewski J, Suszczynska-Falecka Z, Rybaczuk M. Czestosc wystepowania wola u dzieci zamieszkalych na wsi a stezenie jpdu, wapnia I magnezu w wodach do picia na terenie woj bialostockiego [Goiter incidence among children living in the villages in the Bialystok district and the concentrations of iodine, calcium and magnesium in drinking water]. Roczniki Panstwowego Zakladu Higieny, 1981, 32 : Lutynski R. Wystepowanie wola endemicznego-czynniki srodowiskowe I profilaktyka jodowa w polsce Poludniowej [Incidence of endemic goiter-environmental factors and iodine prophylaxis in southern Poland]. Przeglad Epidemiologiczny, 1995, 49 : Polish Society of Endocrinology. Obligatory model of iodine prophylaxis and programme of elimination of iodine deficiency in Poland. Endokrynologia Polska, 1998, 49 (Suppl 1): Lewinski A, Karbownik M, Tomaszewski W, Skowronska-Jozwiak E, Gloskowska-Koptas R, Koptas W. Incidence of goitre and urinary iodine concentration in schoolchildren in the town of Opoczno (the Piotrkow Trybunalski Voivodship). Endokrynologia Polska, 1998, 49 (Suppl 1-3): Ryabakowa M, Tylek-Lemanska D, Ratajczak R, Soltsik-Wilk E. Iodine deficiency in children form Tarnobrzeg district. Endokrynologia Polska, 1998, 49 (Suppl 1-3): Wasilowa R, Zak T. Iodine deficiency in a selected region of the Sudeten Land (Karpacz). Endokrynologia Polska, 1998, 49 (Suppl 1-3): Szewczyk L, Jaklinska T, Ben-Skowronek I, Witkowski D. "ThyroMobil" studies on iodine deficiency in the Lublin region. Endokrynologia Polska, 1998, 49 (Suppl 1-3): Przybylik-Maurek E, Szybinski Z, Slizowski K. Influence of the Vistula river on iodine deficiency and prevalence of goitre in school children. Endokrynologia Polska, 1998, 49 (Suppl 1-3): Dorant B, Korpal-Szczyrska M, kaminska H, Birkholz D, Bitel L, Kosiak W. Prevalence of goiter in children in selected towns in seaside zone. Endokrynologia Polska, 1998, 49 (Suppl 1-3): Bandurska-Stankiewicz E, Tarasiewicz U. Iodine deficiency and prevalence of goiter in the Olsztyn region. Endokrynologia Polska, 1998, 49 (Suppl 1-3): Kaminski M, Drewniak W, Szymanski W, Junik R, Kaminska A. Wydalanie jodu I czynnosc tarczycy u kobiet w ciazy w regionie Bydogoszczy Przed I po wprowadzeniu obligatoryjnej profilaktyki jodowej w polsce [Urinary iodine excretion and thyroid function in pregnant women of Bydgoszcz District prior to and after the introduction of iodized salt]. Ginekologia Polska, 2003, 74 : Naskalski JW, Drozdz R, Solnica B, Rostworowski W, Szybinski Z, Huszno B, Trofimiuk M, Buziak-Bereza M. Analityczne aspekty badania niedoboru jodu w trakcie realizacji Programu Badania Niedoboru Jodu w Polsce [Analytical problems of iodine defficiency examination in Polish Nation-wide deficit control program]. Przeglad Lekarski, 2004, 61 : Szybinski Z. Actual effectiveness and perspective of the iodine prophylaxis in Poland. Endokrynologia Polska, 2004, 55 :

9 ADDITIONAL REFERENCES Reference 5397 Reference 5423 Reference 5507 Reference 5603 Reference 5614 Buziak-Bereza M, Golkowski F, Szybinski Z. Badania nad niedoborem jodu wsród doroslych mieszkanców Krakowa [Studies on iodine deficiency in adult population of Cracow]. Przeglad Lekarski, 2005, 62 : Rybakowa M, Tylek-Lemanska D. Aktualny stan dzialan grupy endokrynologów krakowskich Instytutu Pediatrii CMUJ, nad eliminacja chorób z niedoboru jodu (IDD) w Polsce [Real activity of Krakow endocrine group in Institute of Pediatrics CMUJ on the eradication of IDD in Polish children]. Przeglad Lekarski, 2005, 62 : Kretowski A, Brzozowska M, Zonenberg A, Borawski J, Kinalska I. Ocena wielkosci tarczycy w populacji dzieci szkolnych w wieku 6-13 lat z prawidlowym jodu z moczem a przydantnosc stosowanych dotychczas wartosci referencyjnch [Evaluation of the thyroid size among school children aged 6-13 with the normal iodine excretion in the urine and the usability of referential values still applied]. Endokrynologia, Diabetologia i Choroby Przemiany Materii Wieku Rrozwojowego, 2005, 11 : Bar-Andziak E, Grzesiuk W, Lazecki D, Slon M, Kondracka A. Podaz jodu u dzieci szkolnych w trzy lata po wpprowadzeniu obowiazkowego jodowania soli spozywczej [Iodine supply in school children three years after introduction of obligatory salt iodization]. Polski Merkuriusz Lekarski, 2004, 16 : Brodowski J, Kozielec T, Karakiewicz B, Durska G, Kedzierska E. Stezenie tyreoglobuliny w losowo wybranej grupie dzieci I mlodziezy szczecinskiej w okresie obowiazywania populacyjnego modelu profilaktyki jodowej [Thyroglobulin concentration after introduction of population iodine prophylaxis in random selected group of children and adolescents in Szczecin region]. Polski Merkuriusz Lekarski, 2006, 20 :