Prof. dr hab. Grzegorz Węgrzyn

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1 Curriculum Vitae Prf. dr hab. Grzegrz Węgrzyn Current affiliatin and fficial address: Department f Mlecular Bilgy, Faculty f Bilgy, University f Gdansk, Wita Stwsza 59, Gdansk, Pland Tel Fax: wegrzyn@bitech.ug.edu.pl Educatin, degrees and academic titles Studies , Bilgy, specialty: Mlecular Bilgy, University f Gdansk (Pland), Faculty f Bilgy, Gegraphy and Oceanlgy MSc 1987, Bilgy, specialty: Mlecular Bilgy, University f Gdansk (Pland), Faculty f Bilgy, Gegraphy and Oceanlgy PhD 1991, Bilgical Sciences (Bilgy), specialty: Mlecular Bilgy; University f Gdansk (Pland), Faculty f Bilgy, Gegraphy and Oceanlgy Habilitatin (D.Sc.) 1995, Bilgical Sciences (Bilgy), specialty: Mlecular Genetics; University f Gdansk (Pland), Faculty f Bilgy, Gegraphy and Oceanlgy Prfessr (title; Bilgical Sciences) 1998, University f Gdansk (Pland), Faculty f Bilgy, Gegraphy and Oceanlgy Freign scientific schlarships and residences Chair f Bichemistry, University f Nttingham Medical Schl, Great Britain 1991 Mlecular Genetics Center, University f Califrnia, San Dieg, USA 1992 Career/emplyment Research Assistant , Department f Mlecular Bilgy, Faculty f Bilgy, University f Gdansk Lecturer (Adiunkt) , Department f Mlecular Bilgy, Faculty f Bilgy, University f Gdansk Assistant Prfessr , Department f Mlecular Bilgy, Faculty f Bilgy, University f Gdansk Assciate Prfessr , Department f Mlecular Bilgy, Faculty f Bilgy, University f Gdansk Prfessr d 1999, Department f Mlecular Bilgy, Faculty f Bilgy, University f Gdansk Other emplyments r functins Part time , Sea Bilgy Centre f the Plish Academy f Sciences, Oceanlgy Institute f the Plish Academy f Sciences

2 Scientific crdinatr at Labratry f Mlecular Bilgy in the Institute f Bichemistry and Biphysics f the Plish Academy f Sciences by the University f Gdansk Academic functins Head f Labratry f Mlecular Genetics f University f Gdansk 1996-present Head f Department f Mlecular Bilgy f University f Gdansk 1996-present Dean f Faculty f Bilgy, Gegraphy and Oceanlgy f University f Gdansk Vice-President fr Research Affairs f University f Gdansk 2008-present Academic staff educatin 37 PhDs prmted, 6 Assistant Prfessrs guided Membership and Functins in Prfessinal Organizatins Member f the Plish Bichemical Sciety 1991-present Member f Plish Genetic Sciety 1991-present, President f the Gdansk Branch , Member f the Main Cuncil , President Member f American Sciety fr Bichemistry and Mlecular Bilgy 2003-present Member f Internatinal Sciety fr Plasmid Bilgy 2003-present Expert experience (academic) Over 300 publicatins critically revieved in the internatinal peer-reviewed scientific jurnals as well as numerus Plish and freign grant applicatins reviewed. Editrial experience Editr f scientific jurnals FEMS Micrbilgy Reviews Plasmid Micrbial Cell Factries Acta Bichimica Plnica Editr-in-Chief 2009-present Member f Editrial Bards Jurnal f Applied Genetics Jurnal f Bimlecular Screening Metablic Brain Disease Oceanlgia Hnrs and Awards PhD thesis awarded by the President f the University f Gdansk 1992, Gdansk Award (schlarship) f the Fundatin fr Plish Science fr Outstanding Yung Scientists 1993, Warsaw Prizes f the Plish Bichemical Sciety fr the best experimental wrk in the field f bichemistry, perfrmed in Plish labratries and published in the frmer year 1994, 1995, 1999, 2000, 2004 Award f the Minister f Natinal Educatin fr scientific achievements (stringent DNA replicatin cntrl publicatin cycle) 1995 President f the University f Gdansk Award fr the Intercllegiate Faculty f Bitechnlgy UG-MUG management, develpment and rganizatin 1996, Gdansk Habilitatin awarded by the Prime Minister 1997, Warsaw Prizes f the Plish Genetic Sciety fr the best publicatins in the field f genetics, based n wrk perfrmed in Plish labratries 1999, 2001, 2004, 2007 Subsidy f the Fundatin fr Plish Science (prfessrship) 2000, Warsaw Plish Bichemical Sciety Award fr the best review article 2000, Warsaw President f the University f Gdansk Award, fr scientific achievements in the field f prtein stress prtectin prcess 2000, Gdansk

3 Medal f the Cmmittee fr Natinal Educatin 2001, Warsaw President f the University f Gdansk Award, fr scientific achievements in the field f the marine bacterium Vibri harveyi bilgy and its ptential use as an envirnmental mutagenic pllutin indicatr 2001, Gdansk President f the University f Gdansk Award, fr the tutrial achievements and the Faculty f Bilgy, Gegraphy and Oceanlgy management 2003, Gdansk President f the University f Gdansk Award, fr the rganisatin achievements 2004, Gdansk Hevelius Award Scientific Award f the City f Gdansk 2004, Gdansk Award f the Minister f Science and Higher Educatin fr scientific achievements 2010, Warsaw Scientific interests Plasmids and bacteriphage DNA replicatin mechanisms Cntrl f gene expressin in prkarytes Human genetic diseases, particularly neurdegenerative inherited metablic diseases Electrical bi-chips Scientific experience and achievements Reslving the replicatin mlecular mechanism f few plasmids with the stringent r relaxed metablic cntrl, pinpinting the essential rle f the transcriptin in the regulatin f DNA replicatin initiatin Mechanism f the DnaA prtein activated transcriptin, firstly claimed that bacterial transcriptinal activatrs can interact with the RNA plymerase beta subunit. Bacterial cells biluminescence plays a rle in DNA repair by stimulating the phtactivatin prcess. SeqA prtein, the main negative regulatr f the bacterial chrmsme replicatin initiatin, is als a transcriptin factr; describing its mechanism f actin. Describing the physilgical cnditins regulating the efficiency f the RNA pliadenylatin prcess in bacterial cells (as a first in the Wrld). Nvel treatment methd fr the lyssmal strage diseases, invlving flavnid genistein mdulated gene expressin. Prpsed bilgical functin f the Shiga-txin cding bacteriphages f the enterhemrrhagic Escherichia cli hst cells. Business experience and achievements Unitet States Patent, patent n. US 8,178,609 B2, 2012: Isflavnes fr treating mucplysaccharidses. Genzyme cmpany expert BiMarine cmpany expert Phage Cnsultants cmpany expert Cparatin with 3G Therapeutics cmpany in the field f research cmmercialisatin Scientific papers (Impact Factr 750, H-Index = 27, citatins - >3000, publicatins - >300, cnference cmmunicatins - >400, bks 1, edited bks 1) Patents 1. Unitet States Patent, patent n. US 8,178,609 B2, 2012, Isflavnes fr treating mucplysaccharidses ISI Master Jurnal List Publicatins (293 publicatins) 1. Obuchwski M, Węgrzyn G: Erichrme black T as a dye fr agarse gel electrphresis. Acta Bichimica Plnica 1991, 38: Węgrzyn G, Kwaśnik E, Taylr K: Replicatin f plasmid in amin acid-starved strains f Escherichia cli. Acta Bichimica Plnica 1991, 38: Grzegrz Węgrzyn, Neubauer P, Krueger S, Hecker M, Taylr K: Stringent cntrl f replicatin f plasmids derived frm cliphage. Mlecular and General Genetics 1991, 225: Węgrzyn G, Pawłwicz A, Taylr K: O prtein. Jurnal f Mlecular Bilgy 1992, 226: Węgrzyn G, Taylr K: Inheritance f the replicatin cmplex by ne f tw daughter cpies during plasmid replicatin in Escherichia cli. Jurnal f Mlecular Bilgy 1992, 226:

4 6. Węgrzyn G, Glass RE, Thmas MS: Invlvement f the Escherichia cli RNA plymerase subunit in transcriptinal activatin by the bacteriphage lambda CI and CII prteins. Gene 1992, 122:1-7. Pawłwicz A, Węgrzyn G, Taylr K: Effect f cliphage P gene mutatins n the stability f the O prtein, the initiatr f DNA replicatin. Acta Bichimica Plnica 1993, 40: Salwa A, Węgrzyn G: Izlacja wirusa maedi wiec w Plsce. Medycyna Weterynaryjna 1993, 49: Herman A, Węgrzyn A, Węgrzyn G: Regulatin f replicatin f plasmid pbr322 in amin acidstarved Escherichia cli strains. Mlecular and General Genetics 1994, 243: Herman A, Węgrzyn A, Węgrzyn G: Cmbined effect f stringent r relaxed respnse, temperature and rm functin n the replicatin f puc plasmids in Escherichia cli. Acta Bichimica Plnica 1994, 41: Herman A, Węgrzyn A, Węgrzyn G: Differential replicatin f plasmids during stringent and relaxed respnse f Escherichia cli. Plasmid 1994, 32: Szalewska A, Węgrzyn G, Taylr K: Neither absence nr excess f O initiatr-digesting ClpXP prtease affects plasmid r phage replicatin in Escherichia cli. Mlecular Micrbilgy 1994, 13: Szalewska-Pałasz A, Węgrzyn A, Herman A, Węgrzyn G: The mechanism f the stringent cntrl f plasmid DNA replicatin. EMBO Jurnal 1994, 13: Szalewska-Pałasz A, Węgrzyn G: An additinal rle f transcriptinal activatin f ri in the regulatin f plasmid replicatin in Escherichia cli. Bichemical and Biphysical Research Cmmunicatins 1994, 205: Herman A, Węgrzyn G: Effect f increased ppgpp cncentratin n DNA replicatin f different replicns in Escherichia cli. Jurnal f Basic Micrbilgy 1995, 35: Taylr K, Węgrzyn G: Replicatin f cliphage lambda DNA. FEMS Micrbilgy Reviews 1995, 17: Węgrzyn G, Węgrzyn A, Knieczny I, Bielawski K, Knpa G, Obuchwski M, Helinski DR, Taylr K: Invlvement f the hst initiatr functin dnaa in the replicatin f cliphage. Genetics 1995, 139: Węgrzyn G, Szalewska-Pałasz A, Węgrzyn A, Obuchwski M, Taylr K: Transcriptinal activatin f cliphage DNA replicatin is regulated by the hst DnaA initiatr functin. Gene 1995, 154: Węgrzyn G: Czterfsfran guanzyny, ppgpp, jak czynnik ścisłej kntrli replikacji DNA. Pstępy Bichemii 1995, 41: Węgrzyn A, Węgrzyn G, Taylr K: Prtectin f cliphage O initiatr prtein frm prtelysis in the assembly f the replicatin cmplex in viv. Virlgy 1995, 207: Węgrzyn A, Węgrzyn G, Taylr K: carried ut by the inherited replicatin cmplex. Mlecular and General Genetics 1995, 245:, Szalewska-Pałasz A, Węgrzyn G: Inhibitin f transcriptin starting frm bacteriphage pr prmter during the stringent respnse in Escherichia cli: implicatins fr DNA replicatin. Acta Bichimica Plnica 1995, 42: Węgrzyn G: Amplificatin f plasmids in Escherichia cli rela mutants. Jurnal f Bitechnlgy 1995, 43: Węgrzyn A, Węgrzyn G: Transcriptinal activatin f ri regulates plasmid replicatin in amin acid-starved Escherichia cli cells. Bichemical and Biphysical Research Cmmunicatins 1995, 214: Węgrzyn A, Węgrzyn G, Taylr K: Disassembly f the cliphage replicatin cmplex due t heat shck inductin f the gre pern. Virlgy 1996, 217: Neubauer P, Wróbel B, Węgrzyn G: DNA degradatin at elevated temperatures after plasmid amplificatin in amin acid-starved Escherichia cli cells. Bitechnlgy Letters 1996, 18: Obuchwski M, Węgrzyn G: Synthesis f the bacteriphage P prtein in amin acid-starved Escherichia cli cells. Bichemical and Biphysical Research Cmmunicatins 1996, 222: Węgrzyn G, Węgrzyn A, Pankiewicz A, Taylr K: Allele specificity f the Escherichia cli dnaa gene functin in the replicatin f plasmids derived frm phage. Mlecular and General Genetics 1996, 252: Węgrzyn A, Taylr K, Węgrzyn G: The cbpa chaperne gene functin cmpensates fr dnaj in plasmid replicatin during amin acid starvatin f Escherichia cli. Jurnal f Bacterilgy 1996, 178: Szalewska-Pałasz A, Węgrzyn A, Obuchwski M, Pawłwski R, Bielawski K, Thmas MS, Węgrzyn G: Drastically decreased transcriptin frm CII-activated prmters is respnsible fr impaired lysgenizatin f the Escherichia cli rpa341 mutant by bacteriphage. FEMS Micrbilgy Letters 1996, 144:21-27.

5 31. Węgrzyn A, Węgrzyn G, Herman A, Taylr K: Prtein inheritance: plasmid replicatin perpetuated by the heritable replicatin cmplex. Genes t Cells 1996, 1: Taylr K, Węgrzyn G, Węgrzyn A, Szalewska-Pałasz A, Herman A, Obuchwski M, Śrutkwska S, Knpa G: Escherichia cli initiatr prtein DnaA, cell cycle, and cntrl f plasmid replicatin. Bulletin f the Plish Academy f Sciences, Bilgical Sciences 1996, 44: Obuchwski M, Węgrzyn A, Szalewska-Pałasz A, Thmas MS, Węgrzyn G: An RNA plymerase subunit mutant impairs N-dependent transcriptinal antiterminatin in Escherichia cli. Mlecular Micrbilgy 1997, 23: Obuchwski M, Giladi H, Kby S, Szalewska-Pałasz A, Węgrzyn A, Oppenheim AB, Thmas MS, Węgrzyn G: Impaired lysgenisatin f the Escherichia cli rpa341 mutant by bacteriphage is due t the inability f CII t act as a transcriptinal activatr. Mlecular and General Genetics 1997, 254: Wróbel B, Węgrzyn G: Replicatin and amplificatin f plasmids in Escherichia cli during amin acid starvatin and limitatin. FEMS Micrbilgy Letters 1997, 153: Węgrzyn G: Antyterminacja transkrypcji u bakterifaga. Pstępy Bilgii Kmórki 1997, 24 (Suplement 8): Węgrzyn G, Węgrzyn A: Aktywacja transkrypcji w kmórkach Escherichia cli. Pstępy Bilgii Kmórki 1997, 24 (Suplement 8): Wróbel B, Węgrzyn G: Differential amplificatin efficiency f pmb1 and p15a (ClE1-type) replicns in Escherichia cli stringent and relaxed strains starved fr particular amin acids. Micrbilgical Research 1997, 152: Wróbel B, Węgrzyn G: Replicatin f plasmids derived frm P1, F, R1, R6K and RK2 replicns in amin acid-starved Escherichia cli stringent and relaxed strains. Jurnal f Basic Micrbilgy 1997, 37: Obuchwski M, Shtland Y, Kby S, Giladi H, Gabig M, Węgrzyn G, Oppenheim AB: Stability f CII is a key element in the cld stress respnse f bacteriphage infectin. Jurnal f Bacterilgy 1997, 179: Mikiewicz D, Wróbel B, Węgrzyn G, Płucienniczak A: Islatin and characterizatin f a ClE1-like plasmid frm Enterbacter agglmerans with a nvel variant f rm gene. Plasmid 1997, 38: Wróbel B, Węgrzyn G: Amplificatin f psc101 replicns in Escherichia cli during amin acid limitatin. Jurnal f Bitechnlgy 1997, 58: Taylr K, Węgrzyn G: Regulatin f bacteriphage replicatin. W: Mlecular Micrbilgy (S. J. W. Busby, C. M. Thmas, N. L. Brwn, Red.) 1998, Springer Verlag, Berlin-Heidelberg, str Wróbel B, Murphy H, Cashel M, Węgrzyn G: Guansine tetraphsphate (ppgpp)-mediated inhibitin f the activity f the bacteriphage pr prmter in Escherichia cli. Mlecular and General Genetics 1998, 257: Wróbel B, Węgrzyn G: Replicatin regulatin f ClE1-like plasmids in amin acid-starved Escherichia cli. Plasmid 1998, 39: Gabig M, Obuchwski M, Ciesielska A, Latała B, Węgrzyn A, Thmas MS, Węgrzyn G: The Escherichia cli RNA plymerase subunit and transcriptinal activatin by bacteriphage CII prtein. Acta Bichimica Plnica 1998, 45: Węgrzyn A, Herman-Antsiewicz A., Taylr K, Węgrzyn G: Mlecular mechanism f heat shckprvked disassembly f the cliphage replicatin cmplex. Jurnal f Bacterilgy 1998, 180: Szalewska-Pałasz A, Węgrzyn A, Błaszczak A, Taylr K, Węgrzyn G: DnaA-stimulated transcriptinal activatin f ri: Escherichia cli RNA plymerase subunit as a transcriptinal activatr cntact site. Prceedings f the Natinal Academy f Science f USA 1998, 95: Śrutkwska S, Knpa G, Węgrzyn G: A methd fr islatin f plasmid DNA replicatin intermediates frm unsynchrnized bacterial cultures fr electrn micrscpy analysis. Acta Bichimica Plnica 1998, 45: Wróbel B, Śrutkwska S, Węgrzyn G: Bichemical and genetic analysis f W, the newly islated lambdid phage. Acta Bichimica Plnica 1998, 45: Gabig M, Obuchwski M, Śrutkwska S, Węgrzyn G: Regulatin f replicatin f phage and plasmid at lw temperature. Mlecular and General Genetics 1998, 258: Wróbel B, Herman-Antsiewicz A, Szalewska-Pałasz A, Węgrzyn G: Plyadenylatin f p RNA in the regulatin f bacteriphage develpment. Gene 1998, 212: Herman-Antsiewicz A, Śrutkwska S, Taylr K, Węgrzyn G: Replicatin and maintenance f plasmids devid f the Cr repressr autregulatry lp in Escherichia cli. Plasmid 1998, 40: Węgrzyn A, Węgrzyn G: Randm inheritance f the replicatin cmplex by ne f tw daughter plasmid cpies after a replicatin rund in Escherichia cli. Bichemical and Biphysical Research Cmmunicatins 1998, 246:

6 55. Gabig M, Obuchwski M, Węgrzyn A, Szalewska-Pałasz A, Thmas MS, Węgrzyn G: Excess prductin f phage delayed early prteins under cnditins supprting high Escherichia cli grwth rates. Micrbilgy 1998, 144: Herman-Antsiewicz A, Węgrzyn G: Replicatin f plasmid DNA in the Escherichia cli cell cycle. Bichemical and Biphysical Research Cmmunicatins 1998, 247: Herman-Antsiewicz A, Węgrzyn A, Taylr K, Węgrzyn G: DnaA-mediated regulatin f phagederived replicns in the absence f pr and Cr functin. Virlgy 1998, 249: Szalewska-Pałasz A, Wróbel B, Węgrzyn G: Rapid degradatin f plyadenylated p RNA. FEBS Letters 1998, 432: Szalewska-Pałasz A, Weigel Ch, Speck Ch, Śrutkwska S, Knpa G, Lurz R, Marszałek J, Taylr K, Messer W, Węgrzyn G: Interactin f the Escherichia cli DnaA prtein with bacteriphage DNA. Mlecular and General Genetics 1998, 259: Szalewska-Pałasz A, Lemieszek E, Pankiewicz A, Węgrzyn A, Helinski DR, Węgrzyn G: Escherichia cli dnaa gene functin and bacteriphage replicatin. FEMS Micrbilgy Letters 1998, 167: Węgrzyn A, Szalewska-Pałasz A, Błaszczak A, Liberek K, Węgrzyn G: Differential inhibitin f transcriptin frm 70- and 32-dependent prmters by rifampicin. FEBS Letters 1998, 440: Ktlarz A, Szalewska-Pałasz A, Węgrzyn G, Lipińska B: Ecnmical and efficient verprductin f the Escherichia cli sigma 32 transcriptin factr. Bitechnlgy Techniques 1998, 12: Węgrzyn G: Replicatin f plasmids during bacterial respnse t amin acid starvatin. Plasmid 1999, 41: Węgrzyn A, Węgrzyn G: Regulacja replikacji DNA bakterifaga i plazmidów. Pstępy Bichemii 1999, 45: Glinkwska M, Węgrzyn A, Węgrzyn G: Replicatin f bacteriphage dnaa rac hsts. Genetics 1999, 151: Śrutkwska S, Caspi R, Gabig M, Węgrzyn G: Detectin f DNA replicatin intermediates after tw-dimensinal agarse gel electrphresis using a flurescein-labeled prbe. Analytical Bichemistry 1999, 269: Węgrzyn A, Wróbel B, Węgrzyn G: Altered bilgical prperties f cell membranes in Escherichia cli dnaa and seqa mutants. Mlecular and General Genetics 1999, 261: Knpa G, Szalewska-Pałasz A, Schmidt A, Śrutkwska S, Messer W, Węgrzyn G: The presence f tw DnaA-binding sequences is required fr efficient interactin f the Escherichia cli DnaA prtein with each particular weak DnaA bx regin. FEMS Micrbilgy Letters 1999, 174: Kędzierska S, Staniszewska M, Ptrykus J, Węgrzyn G: The effect sme antibitic-resistancecnferring plasmids n the remval f the heat-aggregated prteins frm Escherichia cli. FEMS Micrbilgy Letters 1999, 176: Herman-Antsiewicz A, Węgrzyn G: Regulatin f cpy number and stability f phage derived ptc 1 plasmid in the light f the dimer/multimer catastrphe hypthesis. FEMS Micrbilgy Letters 1999, 176: Słmińska M, Neubauer P, Węgrzyn G: 5'-diphsphate-3'-diphsphate. Virlgy 1999, 262: Messer W, Blaesing F, Majka J, Nardmann J, Schaper S, Schmidt A, Seitz H, Speck Ch, Tungler D, Węgrzyn G, Weigel Ch, Welzeck M, Zakrzewska-Czerwińska J: Functinal dmains f DnaA prteins. Bichimie 1999, 81: Szalewska-Pałasz A, Węgrzyn G: Czterfsfran guanzyny (ppgpp) - regulatr metablizmu kmórek bakteryjnych w warunkach głdwych. W: Na pgraniczu chemii i bilgii (H. Krniak, J. Barciszewski, Red.) 1999, Wydawnictw Nukwe Uniwersytetu im. Adama Mickiewicza w Pznaniu, tm III, str Czyż A, Wróbel B, Węgrzyn G: Vibri harveyi biluminescence plays a rle in stimulatin f DNA repair. Micrbilgy 2000, 146: Jakimwicz D, Majka J, Lis B, Knpa G, Węgrzyn G, Messer W, Schrempf H, Zakrzewska-Czerwińska J: Structure and regulatin f the dnaa prmter regin f three Streptmyces species. Mlecular and General Genetics 2000, 262: Czyż A, Jasiecki J, Bgdan A, Szpilewska H, Węgrzyn G: Genetically mdified Vibri harveyi strains as ptential biindicatrs f mutagenic pllutin f marine envirnments. Applied and Envirnmental Micrbilgy 2000, 66: Ptrykus K, Wróbel B, Węgrzyn A, Węgrzyn G: Replicatin f rij-based plasmid DNA during the stringent and relaxed respnses f Escherichia cli. Plasmid 2000, 44: Jakimwicz D, Majka J, Knpa G, Węgrzyn G, Messer W, Schrempf H, Zakrzewska-Czerwińska J: Architecture f the Sterptmyces lividans DnaA prtein-replicatin rigin cmplexes. Jurnal f Mlecular Bilgy 2000, 298: Knpa G, Barańska S, Węgrzyn A, Węgrzyn G: Bacteriphage and hst mutants causing the rlling-circle DNA replicatin early after infectin. FEBS Letters 2000, 472:

7 80. Węgrzyn A, Węgrzyn G: Frmatin and stability f bacteriphage replicatin cmplexes in UVirradiated Escherichia cli. Current Micrbilgy 2000, 41: Węgrzyn A, Czyż A, Gabig M, Węgrzyn G: ClpP/ClpX-mediated degradatin f the bacteriphage O prtein and regulatin f phage and plasmid replicatin. Archives f Micrbilgy 2000, 174: Guzw-Krzemińska A, Węgrzyn G: Ptential use f restrictin analysis f PCR-amplified DNA fragments in cnstructin f mlecular data-based identificatin keys f lichens. Myctaxn 2000, 76: Kijewska A, Słmińska M, Węgrzyn G, Rkicki J: A PCR-RFLP assay fr identificatin f Anisakis simplex frm different gegraphical regins. Mlecular and Cellular Prbes 2000, 14: Czyż A, Węgrzyn G: On the functin and evlutin f bacterial luminescence. W: Biluminescence and Chemiluminescence 2001(J. F. Case, P. J. Herring, B. H. Rbisn, S. H. D. Haddck, L. J. Kricka, P. E. Stanley, Red.), Wrld Scientific Publishing C., Singapre, str Latała B, Obuchwski M, Węgrzyn G: Bacteriphage ciii gene prduct has an additinal functin apart frm inhibitin f cii degradatin. Virus Genes 2001, 22: Czyż A, Zielke R, Knpa G, Węgrzyn G: Vibri harveyi insertinal mutant in the cgta (bg, yhbz) gene, whse hmlgues are present in diverse rganisms ranging frm bacteria t humans and are essential genes in many bacterial species. Micrbilgy 2001, 147: Barańska S, Gabig M, Węgrzyn A, Knpa G, Herman-Antsiewicz A, Hernandez P, Schvartzman JB, Helinski DR, Węgrzyn G: Regulatin f the switch frm early t late bacteriphage DNA replicatin mde. Micrbilgy 2001, 147: Węgrzyn A, Węgrzyn G: Inheritance f the replicatin cmplex: a unique r cmmn phenmenn in the cntrl f DNA replicatin? Archives f Micrbilgy 2001, 175: Herman-Antsiewicz A, Obuchwski M, Węgrzyn G: A plasmid clning vectr with precisely regulatable cpy number in Escherichia cli. Mlecular BitechnlgyC 2001, 17: Messer W, Blaesing F, Jakimwicz D, Majka J, Nardmann J, Schaper S, Seitz H, Speck Ch, Weigel Ch, Węgrzyn G, Welzeck M, Zakrzewska-Czerwińska J: Bacterial replicatin initiatr DnaA. Rules fr DnaA binding and rles f DnaA in rigin unwinding and helicase lading. Bichimie 2001, 83: Węgrzyn G, Węgrzyn A, Barańska S, Czyż A: Regulatin f bacteriphage lambda develpment. Recent Research Develpments in Virlgy 2001, 3, Jasiecki J, Czyż A, Gabig M, Węgrzyn G: Cnstructin and use f a brad-hst-range plasmid expressing the lamb gene fr utilizatin f bacteriphage vectrs in the marine bacterium Vibri harveyi. Marine Bitechnlgy 2001, 3: Wang Z, Le G, Shi Y, Węgrzyn G: Medium design fr plasmid DNA prductin based n stichimetric mdel. Prcess Bichemistry 2001, 36: Czyż A, Zielke R, Węgrzyn G: Rapid degradatin f bacteriphage O prtein by ClpP/ClpX prtease influences the lysis-versus-lysgenizatin decisin f the phage under certain grwth cnditins f the hst cells. Archives f Virlgy 2001, 146: Glinkwska M, Knpa G, Węgrzyn A, Herman-Antsiewicz A, Weigel Ch, Seitz H, Messer W, Węgrzyn G: The duble mechanism f incmpatibility between plasmids and Escherichia cli dnaa(ts) hst cells. Micrbilgy 2001, 147: Słmińska M, Węgrzyn A, Knpa G, Skarstad K, Węgrzyn G: SeqA, the Escherichia cli rigin sequestratin prtein, is als a specific transcriptin factr. Mlecular Micrbilgy 2001, 40: Czyż A, Łś M, Wróbel B, Węgrzyn G: Inhibitin f spntaneus inductin f lambdid prphages in Escherichia cli cultures: simple prcedures with pssible bitechnlgical applicatins. BMC Bitechnlgy 2001, 1: Węgrzyn G: The minimal genme paradx. Jurnal f Applied Genetics 2001, 42: Czyż A, Węgrzyn G: Mechanizm, regulacja i rla biluminescencji bakterii. Pstępy Bichemii 2001, 47: Gabig M, Węgrzyn G: An intrductin t DNA chips: principles, technlgy, applicatins and analysis. Acta Bichimica Plnica 2001, 48: Ptrykus J, Węgrzyn G: Chlramphenicl-sensitive Escherichia cli strain expressing the chlramphenicl acetyltransferase (cat) gene. Antimicrbial Agents and Chemtherapy 2001, 45: Guzw-Krzemińska B, Górniak M, Węgrzyn G: Mlecular determinatin keys: cnstructin f keys fr species identificatin based n restrictin fragment length plymrphism. Internatinal Archives f Biscience 2001, 1: Słmińska M, Knpa G, Węgrzyn G, Czyż A: Impaired chrmsme partitining and synchrnisatin f DNA replicatin initiatin in a Vibri harveyi insertinal mutant in the cgta gene cding fr a cmmn GTP-binding prtein. Bichemical Jurnal 2002, 362: Wróbel B, Wegrzyn G: Evlutin f lambdid replicatin mdules. Virus Genes 2002, 24:

8 105. Wang Z, Le G, Shi Y, Węgrzyn G, Wróbel B: A mdel fr regulatin f ClE1-like plasmid replicatin by uncharged trnas in amin acid starved Escherichia cli. Plasmid 2002, 47: Wang Z, Le G, Shi Y, Węgrzyn G: Purificatin f plasmid DNA using a multicmpartment electrlyser separated by ultrafilter membranes. Bitechnlgy Letters 2002, 24: Gabig M, Herman-Antsiewicz A, Kwiatkwska M, Łś M, Thmas MS, Węgrzyn G: The cell surface prtein Ag43 facilitates phage infectin f Escherichia cli in the presence f bile salts and carbhydrates. Micrbillgy 2002, 148: Barańska S, Knpa G, Węgrzyn G: Directinality f plasmid DNA replicatin carried ut by the heritable replicatin cmplex. Nucleic Acids Research 2002, 30: Ptrykus K, Perżył E, Węgrzyn G: po, a prmter fr p RNA synthesis, has a rle in replicatin f plasmids derived frm bacteriphage. Plasmid 2002, 47: Sikra-Brgula A, Słmińska M, Trznkwski P, Zielke R, Myśliwski A, Węgrzyn G, Czyż A: A rle fr the cmmn GTP-binding prtein in cupling f chrmsme replicatin t cell grwth and cell divisin. Bichemical and Biphysical Research Cmmunicatins 2002, 292: Ptrykus K, Barańska S, Węgrzyn A, Węgrzyn G: Cmpsitin f the plasmid heritable replicatin cmplex. Bichemical Jurnal 2002, 364: Czyż A, Plata K, Zielke R, Węgrzyn G: Luminescence-stimulated DNA repair in varius bacterial strains. W: Biluminescence and Chemiluminescence: Prgress and Current Applicatins (P. E. Stanley, L. J. Kricka, Red.) 2002, Wrld Scientific, Lndn, str Wang Z, Le G, Shi Y, Węgrzyn G: Studies n recvery plasmid DNA frm Escherichia cli by heat treatment. Prcess Bichemistry 2002, 38: Węgrzyn G, Thmas MS: Mdulatin f the susceptibility f intestinal bacteria t bacteriphages in respnse t Ag43 phase variatin a hypthesis. Medical Science Mnitr 2002, 8:HY Ptrykus J, Barańska S, Węgrzyn G: Inactivatin f the acra gene is partially respnsible fr chlramphenicl sensitivity f Escherichia cli CM2555 strain expressing the chlramphenicl acetyltransferase gene. Micrbial Drug Resistance 2002, 8: Czyż A, Plata K, Węgrzyn G: Inductin f light emissin by luminescent bacteria treated with UV light and chemical mutagens. Jurnal f Applied Genetics 2002, 43: Czyż A, Szpilewska H, Dutkiewicz R, Kwalska W, Biniewska-Gdlewska A, Węgrzyn G: Cmparisn f the Ames test and a newly develped assay fr detectin f mutagenic pllutin f marine envirnments. Mutatin Research 2002, 519: Węgrzyn G, Węgrzyn A: Stress respnses and replicatin f plasmids in bacterial cells. Micrbial Cell Factries 2002, 1: Ptrykus K, Sants S, Lemnnier M, Diaz-Orejas R, Węgrzyn G: Differential effects f Kid txin n tw mdes f replicatin f lambdid plasmids suggest that this txin acts befre, but nt after, the assembly f the replicatin cmplex. Micrbilgy 2002, 148: Dutkiewicz R, Słmińska M, Węgrzyn G, Czyż A: Overexpressin f the cgta (yhbz, bge) gene, cding fr an essential GTP-binding prtein, impairs the regulatin f chrmsmal functins in Escherichia cli. Current Micrbilgy 2002, 45: Czyż A, Łś M, Wróbel B, Węgrzyn G: Alleviatin f prblems with lambdid prphage inductin in Escherichia cli cultures. W: Life Sciences Technlgy 2002, Wrld Markets Research Centre, Lndn, str Węgrzyn G, Węgrzyn A: Regulatin f bacteriphage DNA replicatin. Current Tpics in Virlgy 2002, 2: Kijewska A, Rkicki J, Sitk J, Węgrzyn G: Ascarididea: a simple DNA assay fr identificatin f eleven species infecting marine and freshwater fish, mammals and fish-eating birds. Experimental Parasitlgy 2002, 101: Węgrzyn G, Czyż A: Hw d marine bacteria prduce light, why are they luminescent, and can we emply bacterial biluminescence in aquatic bitechnlgy? Oceanlgia 2002, 44: Ptrykus K, Węgrzyn G, Hernandez VJ: Multiple mechanisms f transcriptin inhibitin by ppgpp at the lambda PR prmter. Jurnal f Bilgical Chemistry 2002, 277: Węgrzyn G: Intrductin plasmids [Wstęp plazmidy]. Ksms 2002, 51: Czyż A, Węgrzyn G: Nwa metda wykrywania mutagennych zanieczyszczeń wdy mrskiej. Annales Academiae Medici Gedanensis 2002, 32: Guzw-Krzemińska B, Węgrzyn G: A preliminary study n the phylgeny f the genus Melanelia using nuclear large subunit ribsmal DNA sequences. Lichenlgist 2003, 35: Czyż A, Kwalska W, Węgrzyn G: Vibri harveyi mutagenicity assay as a preliminary test fr detectin f mutagenic pllutin f marine water. Bulletin f Envirnmental Cntaminatin and Txiclgy 2003, 70: Czyż A, Plata K, Węgrzyn G: Stimulatin f DNA repair as an evlutinary drive fr bacterial luminescence. Luminescence 2003, 18:

9 131. Słmińska M, Knpa G, Ostrwska J, Kędzierska B, Węgrzyn G, Węgrzyn A: SeqA-mediated stimulatin f a prmter activity by facilitating functins f a transcriptin activatr. Mlecular Micrbilgy 2003, 47: Jasiecki J, Węgrzyn G: Grwth-rate-dependent RNA plyadenylatin in Escherichia cli. EMBO Reprts 2003, 4: Słmińska M, Wahl A, Węgrzyn G, Skarstad K: The degradatin f mutant initiatr prtein DnaA204 by prteases ClpP, ClpQ and Ln is prevented when DNA is SeqA-free. Bichemical Jurnal 2003, 370: Szpilewska H, Czyż A, Węgrzyn G: Experimental evidence fr the physilgical rle f bacterial luciferase in the prtectin f cells against xidative stress. Current Micrbilgy 2003, 47: Słmińska M, Knpa G, Barańska S, Węgrzyn G, Węgrzyn A: Interplay between DnaA and SeqA prteins during regulatin f bacteriphage pr prmter activity. Jurnal f Mlecular Bilgy 2003, 329: Ulanwska K, Sikra A, Węgrzyn G, Czyż A: Rle f the cgta gene functin in DNA replicatin f extrachrmsmal elements in Escherichia cli. Plasmid 2003, 50: Wróbel B, Słmiński B, Węgrzyn G: The ptimal eukarytic signal fr translatin initiatin frm nn-aug cdns, present upstream f bacteriphage P cistrn, in inactive in Escherichia cli. Cellular and Mlecular Bilgy Letters 2003, 8: Glinkwska M, Majka J, Messer W, Węgrzyn G: The mechanism f regulatin f bacteriphage pr prmter activity by Escherichia cli DnaA prtein. Jurnal f Bilgical Chemistry 2003, 278: Zielke R, Sikra A, Dutkiewicz R, Węgrzyn G, Czyż A: Invlvement f the cgta gene functin in stimulatin f DNA repair in Escherichia cli and Vibri harveyi. Micrbilgy 2003, 149: Kędzierska B, Glinkwska M, Iwanicki A, Obuchwski M, Sjka P, Thmas MS, Węgrzyn G: Txicity f the bacteriphage cii gene prduct t Escherichia cli arises frm inhibitin f hst cell DNA replicatin. Virlgy 2003, 313: Szalewska-Pałasz A, Strzelczyk B, Herman-Antsiewicz A, Węgrzyn G, Thmas MS: Genetic analysis f bacteriphage lambda N-dependent antiterminatin suggests a pssible rle fr the RNA plymerase alpha subunit in facilitating specific functins f NusA and NusE. Archives f Micrbilgy 2003, 180: Łś M, Węgrzyn G, Neubauer P: A rle fr bacteriphage T4 ri gene functin in the cntrl f phage develpment during pseudlysgeny and in slwly grwing hst cells. Research in Micrbilgy 2003, 154: Pisik J, Ulanwska K, Gwizdek-Wiśniewska A, Czyż A, Kapuściński J, Węgrzyn G: Alleviatin f mutagenic effects f plycyclic armatic agents (quinacrine mustard, ICR-191 and ICR-170) by caffeine and pentxifylline. Mutatin Research 2003, 530: Strzelczyk B, Słmińska-Wjewódzka M, Węgrzyn G, Węgrzyn A: Nn-randm distributin f GATC sequences in regins f prmters stimulated by the SeqA prtein f Escherichia cli. Acta Bichimica Plnica 2003, 50: Ptrykus J, Węgrzyn G: The acrab lcus is invlved in mdulating intracellular acetyl cenzyme A levels in a strain f Escherichia cli CM2555 expressing the chlramphenicl acetyltransferase (cat) gene. Archives f Micrbilgy 2003, 180: Węgrzyn G, Czyż A: Detectin f mutagenic pllutin f natural envirnment using micrbilgical assays. Jurnal f Applied Micrbilgy 2003, 95: Gabig-Cimińska M, Łś M, Hlmgren A, Albers J, Czyż A, Hintsche R, Węgrzyn G, Enfrs S-O: Detectin f bacteriphage infectin and prphage inductin in bacterial cultures by means f electric DNA chips. Analytical Bichemistry 2004, 324: Łś M, Czyż A, Sell E, Węgrzyn A, Neubauer P, Węgrzyn G: Bacteriphage cntaminatin: is there a simple methd t reduce its deleterius effects in labratry cultures and bitechnlgical factries? Jurnal f Applied Genetics 2004, 45: Gabig-Cimińska M, Hlmgren A, Andresen H, Barken KB, Wumpelmann M, Albers J, Hintsche R, Breitenstein A, Neubauer P, Łś M, Czyż A, Węgrzyn G, Silfversparre G, Jurgen B, Schweder T, Enfrs S- O: Electric chips fr rapid detectin and quantificatin f nucleic acids. Bisensrs and Bielectrnics 2004, 19: Kędzierska B, Lee DJ, Węgrzyn G, Busby SJW, Thmas MS: Rle f the RNA plymerase subunits in CII-dependent activatin f the bacteriphage pe prmter: identificatin f imprtant residues and psitining f the C-terminal dmains. Nucleic Acids Research 2004, 32: Węgrzyn G, Węgrzyn A, Tylki-Szymańska A: A general mdel fr genetic regulatin f turnver f glycsaminglycans suggests a pssible prcedure fr predictin f severity and clinical prgress f mucplysaccharidses. Medical Hyptheses 2004, 62: Katsev AM, Węgrzyn G, Szpilewska H: Effects f hydrgen perxide n light emissin by varius strains f marine luminescent bacteria. Jurnal f Basic Micrbilgy 2004, 44:

10 153. Ptrykus K, Wegrzyn G, Hernandez VJ: Direct stimulatin f the paq prmter by the transcriptin effectr guansine-3,5 -(bis)pyrphsphate in a defined in vitr system. Jurnal f Bilgical Chemistry 2004, 279: Ptrykus J, Węgrzyn G: The ypdi gene cdes fr a putative lipprtein invlved in the synthesis f clanic acid in Escherichia cli. FEMS Micrbilgy Letters 2004, 235: Gabig-Cimińska M, Węgrzyn G, Enfrs S-O: Recent advances n an electric silicn based chip fr analysis f nucleic acids. PharmaChem, 3: Węgrzyn G, Czyż A, Olszewska K: Bilgical functins and early evlutin f bacterial luminescence. Current Trends in Micrbilgy 2004, 1: Czyż A, Węgrzyn G: The Obg subfamily f bacterial GTP-binding prteins: essential prteins f largely unknwn functins that are evlutinarily cnserved frm bacteria t humans. Acta Bichimica Plnica 2005, 52: Węgrzyn G: What des plasmid bilgy currently mean? Summary f the Plasmid Bilgy 2004 Meeting. Plasmid 2005, 53: Węgrzyn G, Węgrzyn A: Genetic switches during bacteriphage lambda develpment. Prgress in Nucleic Acid Research and Mlecular Bilgy 2005, 79: Pdgórska B, Chęć E, Ulanwska K, Węgrzyn G: Optimisatin f the micrbilgical mutagenicity assay based n genetically mdified Vibri harveyi strains. Jurnal f Applied Genetics 2005, 46: Łyżeń R, Węgrzyn G: Sensitivity f dark mutants f varius strains f luminescent bacteria t reactive xygen species. Archives f Micrbilgy 2005, 183: Jasiecki J, Węgrzyn G: Lcalizatin f Escherichia cli ply(a) plymerase I in cellular membrane. Bichemical and Biphysical Research Cmmunicatins 2005, 329: Łś M, Łś J, Blhm L, Spillner E, Grunwald T, Albers J, Hintsche R, Węgrzyn G: Rapid detectin f viruses using electrical bichips and anti-virin sera. Letters in Applied Micrbilgy 2005, 40: Czyż A, Zielke R, Węgrzyn G: A nvel Virbi hraveyi mutant with altered qurum sensing regulatin. Oceanlgical and Hydrbilgical Studies 2005, 34: Węgrzyn G: RNA plyadenylatin in bacteria: regulatin and imprtance in cell physilgy and bitechnlgy. BiTech Internatinal 2005, 17: Węgrzyn G, Kurlenda J, Liberek A, Tylki-Szymańska A, Czartryska B, Pitrwska E, Jakóbkiewicz- Banecka J, Węgrzyn A: Atypical micrbial infectins f digestive tract may cntribute t diarrhea in mucplysaccharidsis patients: a MPS I case study. BMC Pediatrics 2005, 5: Jakóbkiewicz-Banecka J, Klska A, Stepnwska M, Banecki B, Węgrzyn A, Węgrzyn G: A bacterial mdel fr studying effects f human mutatins in viv: Escherichia cli strains mimicking a cmmn plymrphism in the human MTHFR gene. Mutatin Research 2005, 578: Iwanicki A, Hinc K, Serr S, Węgrzyn G, Obuchwski M: Transcriptin in the prpc ylq regin in Bacillus subtilis. Archives f Micrbilgy 2005, 183: Pisik J, Gwizdek-Wiśniewska A, Ulanwska K, Ochciński J, Czyż A, Węgrzyn G: Methylxanthines (caffeine, pentxifylline and thephylline) decrease the mutagenic effect f daunmycin, dxrubicin and mitxantrne. Acta Bichimica Plnica 2005, 52: Łś M, Węgrzyn G: Elektryczne bichipy. Ksms 2005, 54: Kzakiewicz J, Gajewska M, Łyżeń R, Czyż A, Węgrzyn G: Biluminescence-mediated stimulatin f phtreactivatin in bacteria. FEMS Micrbilgy Letters 2005, 250: Ulanwska K, Pisik J, Gwizdek-Wiśniewska A, Węgrzyn G: Frmatin f stacking cmplexes between caffeine (1,2,3-trimethylxanthine) and 1-methyl-4-phenyl-1,2,3,6- tetrahydrpyridine may attenuate bilgical effects f this neurtxin. Birganic Chemistry 2005, 33: Węgrzyn G: Bilgia mlekularna na pczątku XXI wieku c wiemy życiu na pzimie mlekularnym i jak ptrafimy tę wiedzę wykrzystać. Edukacja Bilgiczna i Śrdwiskwa 2005, 16: Węglewska A, Jakóbkiewicz-Banecka J, Węgrzyn G: A mdified prcedure fr quantitative analysis f mtdna, detecting mtdna depletin. Jurnal f Applied Genetics 2005, 46: Węgrzyn G: Mukplisacharydzy. Praktyka i Klinika Medyczna 2005, 4/5: Klska A, Bhdanwicz J, Knpa G, Tylki-Szymańska A, Jakóbkiewicz-Banecka J, Czartryska B, Liberek A, Węgrzyn A, Węgrzyn G: Changes in hair mrphlgy f mucplysaccharidsis I patients treated with recmbinant human -L-idurnidase (larnidase, Aldurazyme). American Jurnal f Medical Genetics 2005, 139A: Jasiecki J, Węgrzyn G: Transcriptin start sites in the prmter regin f the Escherichia cli pcnb (plasmid cpy number) gene cding fr ply(a) plymerase I. Plasmid 2006, 55: Ulanwska K, Tkaczyk A, Knpa G, Węgrzyn G: Differential antibacterial activity f genistein arising frm glbal inhibitin f DNA, RNA and prtein synthesis in sme bacterial strains. Archives f Micrbilgy 2006, 184:

11 179. Ulanwska K, Węgrzyn G: Mutagenic activity f 1-methyl-4-phenyl-1,2,3,6-tetrahydrpyridine. Jurnal f Applied Genetics 2006, 47: Węgrzyn G, Węgrzyn A: Replikacja DNA bakterifaga: nwe dkrycia dknane przy użyciu stareg mdelu badawczeg. Pstępy Bichemii 2006, 52: Pdgórska B, Węgrzyn G: A mdified Vibri harveyi mutagenicity assay based n biluminescence inductin. Letters in Applied Micrbilgy 2006, 42: Sikra AE, Zielke R, Węgrzyn A, Węgrzyn G: DNA replicatin defect in the Escherichia cli cgta(ts) mutant arising frm reduced DnaA levels. Archives f Micrbilgy 2006, 185: Pitrwska E, Jakóbkiewicz-Banecka J, Barańska S, Tylki-Szymańska A, Czartryska B, Węgrzyn A, Węgrzyn G: Genistein-mediated inhibitin f glycsaminglycan synthesis as a basis fr gene expressin-targeted isflavne therapy fr mucplysaccharidses. Eurpean Jurnal f Human Genetics 2006, 14: Hinc K, Nagórska K, Iwanicki A, Węgrzyn G, Serr SJ, Obuchwski M: Expressin f genes cding fr GerA and GerK spre germinatin receptrs is dependent n the prtein phsphatase PrpE. Jurnal f Bacterilgy 2006, 188: Węgrzyn G: Mżliwści zastswania inżynierii genetycznej w leczeniu chrób układu pkarmweg. Essentia Medica 2006, 29 (Suplement): Jasiecki J, Węgrzyn G: Phsphrylatin f Escherichia cli ply(a) plymerase I and effects f this mdificatin n the enzyme activity. FEMS Micrbilgy Letters 2006, 261: Wyscka A, Knpa G, Węgrzyn G, Wróbel B: Genmic DNA hybridizatin as an attempt t evaluate phylgenetic relatinships f Ostracda. Crustaceana 2006, 79: Chęć E, Pdgórska B, Węgrzyn G: Direct additin f cultures f tester bacteria int semipermeable membrane devices (SPMDs) as a mdified prcedure fr preliminary detectin f mutagenic pllutin f marine envirnment using micrbilgical mutagenicity assays. Mutatin Research 2006, 611: Łyżeń R, Węgrzyn G, Węgrzyn A, Szalewska-Pałasz A: Stimulatin f the pr prmter by Escherichia cli SeqA prtein requires dwnstream GATC sequences and invlves late stages f transcriptin initiatin. Micrbilgy 2006, 152: Wang Z, Yuan Z, Xiang L, Sha J, Węgrzyn G: trna-dependent cleavage f the ClE1 plasmidencded RNA I. Micrbilgy 2006, 152: Wang Z, Xiang L, Sha J, Węgrzyn A, Węgrzyn G: Effects f the presence f ClE1 plasmid DNA in Escherichia cli n the hst cell metablism. Micrbial Cell Factries 2006, 5: Liberek A, Jakóbkiewicz-Banecka J, Świderska J, Szlagatys-Sidrkiewicz A, Landwski P, Klska A, Marek A, Marek K, Węgrzyn G, Krzn M: Transfrming grwth factr 1 (TGF 1) gene plymrphism and pathgenesis and clinical curse f the chrnic inflamatry diseases f digestive tract in children. W: Recent Advances in the Knwledge in Children Bwel Diseases (M. Krzn, J. Walkwiak, B. Kamińska, Red.) 2006, Wydawnictw Adam Marszałek, Truń, str Wang Z, Xiang L, Sha J, Węgrzyn G: Adensine mnphsphate-induced amplificatin f ClE1 plasmid DNA in Escherichia cli. Plasmid 2007, 57: Łś M, Węgrzyn G: Electric bi-chips fr rapid and quantitative detectin f specific bilgical materials. Current Nanscience 2007, 3: Pdgórska B, Pazdr K, Pempkwiak J, Węgrzyn G: The use f a nvel Vibri harveyi luminescence mutagenicity assay in testing marine water fr the presence f mutagenic pllutin. Marine Pllutin Bulletin 2007, 54: Węglewska-Jurkiewicz A, Jakóbkiewicz-Banecka J, Prnicka E, Węgrzyn G: False psitive results f mitchndrial DNA depletin/deletin due t single nucletide substitutins causing appearance f additinal PvuII restrictin sites. Diagnstic Mlecular Pathlgy 2007, 16: Narajczyk M, Barańska S, Szambwska A, Glinkwska M, Węgrzyn A, Węgrzyn G: Mdulatin f plasmid and phage DNA replicatin by Escherichia cli SeqA prtein. Micrbilgy 2007, 153: Kurlenda J, Grinhlc M, Jasek K, Węgrzyn G: RAPD typing f methycillin-resistant Staphylcccus aureus: a 7-year experience in a Plish hspital. Medical Science Mnitr 2007, 13, MT13-MT Słmiński B, Całkiewicz J, Glec P, Węgrzyn G, Wróbel B: Plasmids derived frm Gifsy-1/Gifsy-2, lambdid prphages cntributing t the virulence f Salmnella enterica servar Typhimurium: implicatins fr the evlutin f replicatin initiatin prteins f lambdid phages and enterbacteria. Micrbilgy 2007, 153: Ulanwska K, Majchrzyk A, Mskt M, Jakóbkiewicz-Banecka J, Węgrzyn G: Assessment f antibacterial effects f flavnids by estimatin f generatin times in liquid bacterial cultures. Bilgia 2007, 62: Łś M, Glec P, Łś JM, Węglewska-Jurkiewicz A, Czyż A, Węgrzyn A, Węgrzyn G, Neubauer P: Effective inhibitin f lytic develpment f bacteriphages, P1 and T4 by starvatin f their hst, Escherichia cli. BMC Bitechnlgy 2007, 7:13.

12 202. Narajczyk M, Barańska S, Węgrzyn A, Węgrzyn G: Switch frm t replicatin f bacteriphage DNA: factrs invlved in the prcess and a mdel fr its regulatin. Mlecular Genetics and Genmics 2007, 278: Kędzierska B, Szambwska A, Herman-Antsiewicz A, Lee DJ, Busby SJW, Węgrzyn G, Thmas MS: The C-terminal dmain f the Escherichia cli RNA plymerase subunit plays a rle in the CIdependent activatin f the bacteriphage pm prmter. Nucleic Acids Research 2007, 35: Węgrzyn G, Tylki-Szymańska A, Liberek A, Pitrwska E, Jakóbkiewicz-Banecka J, Marucha J, Czartryska B, Węgrzyn A: Rapid deteriratin f a patient with mucplysaccharidsis type I during interruptin f enzyme replacement therapy. American Jurnal f Medical Genetics 2007, 143A: Grinhlc M, Węgrzyn G, Kurlenda J: Evaluatin f bifilm prductin and prevalence f the icad gene in methicillin-resistant and methicillin-susceptible Staphylcccus aureus strains islated frm patients with nscmial infectins and carriers. FEMS Immunlgy and Medical Micrbilgy 2007, 50: Ulanwska K, Pisik J, Gwizdek-Wiśniewska A, Węgrzyn G: Impaired mutagenic activities f MPDP+ (1-methyl-4-phenyl-2,3-dihydrpyridinium) and MPP+ (1-methyl-4- phenylpyridinium) due t their interactins with methylxanthines. Birganic and Medicinal Chemistry 2007, 15: Szalewska-Pałasz A, Węgrzyn G, Węgrzyn A: Mechanisms f physilgical regulatin f RNA synthesis in bacteria: new discveries breaking ld schemes. Jurnal f Applied Genetics 2007, 48, Pdgórska B, Pazdr K, Węgrzyn G: The use f the Vibri harveyi luminescence mutagenicity assay as a rapid test fr preliminary assessment f mutagenic pllutin f marine sediments. Jurnal f Applied Genetics 2007, 48: Jakóbkiewicz-Banecka J, Węgrzyn A, Węgrzyn G: Substrate deprivatin therapy: a new hpe fr patients suffering frm neurnpathic frms f inherited lyssmal strage diseases. Jurnal f Applied Genetics 2007, 48: Węgrzyn G, Jakóbkiewicz-Banecka J: Mukplisacharydzy jak jedne z nielicznych mżliwych d leczenia chrób dziedzicznych: becnie dstępne terapie i perspektywy. Świat Medycyny i Farmacji 2007, 8, Pdgórska B, Węgrzyn G: The use f marine bacteria in mutagenicity assays. Plish Jurnal f Micrbilgy 2007, 56: Kurlenda J, Grinhlc M, Węgrzyn G: Presence f cna, emp and pls genes and pathgenicity f methicillin-resistant Staphylcccus aureus strains. Wrld Jurnal f Micrbilgy and Bitechnlgy 2008, 24: Łś M, Łś JM, Węgrzyn G: Rapid identificatin f Shiga txin-prducing Escherichia cli (STEC) using electric bichips. Diagnstic Mlecular Pathlgy 2008, 17: Pdgórska B, Królicka A, Łjkwska E, Węgrzyn G: Rapid detectin f mutagens accumulated in plant tissues using a nvel Vibri harveyi mutagenicity assay. Ectxiclgy and Envirnmental Safety 2008, 70: Chęć E, Pdgórska B, Węgrzyn G: Cmparisn f the use f mussels and semipermeable membrane devices fr mnitring and assessment f accumulatin f mutagenic pllutants in marine envirnment in cmbinatin with a nvel micrbilgical mutagenicity assay. Envirnmental Mnitring and Assessment 2008, 140: Wang Z, Jin L, Węgrzyn G, Węgrzyn A: Screening f the smtic pressure-inducible prmter regins frm the whle genme f Escherichia cli by using a nvel clning methd. Bitechnlgy Letters 2008, 30: Malinwska M, Jakóbkiewicz-Banecka J, Klska A, Tylki-Szymańska A, Czartryska B, Pitrwska E, Węgrzyn A, Węgrzyn G: Abnrmalities in the hair mrphlgy f patients with sme but nt all types f mucplysaccharidses. Eurpean Jurnal f Pediatrics 2008, 167: Węgrzyn G, Węgrzyn A: Is trna nly a translatin factr r als a regulatr fr ther prcesses? Jurnal f Applied Genetics 2008, 49: Sawuła W, Banecka-Majkutewicz Z, Kadziński L, Jakóbkiewicz-Banecka J, Węgrzyn G, Nyka W, Banecki B: Imprved HPLC methd fr ttal plasma hmcysteine detectin and quantificatin. Acta Bichimica Plnica 2008, 55: Pitrwska E, Jakóbkiewicz-Banecka J, Tylki-Szymańska A, Liberek A, Maryniak A, Malinwska M, Czartryska B, Puk E, Klska A, Liberek T, Barańska S, Węgrzyn A, Węgrzyn G: Genistin-rich isflavne extract in substrate reductin therapy fr Sanfilipp syndrme: an pen-label, pilt study in 10 pediatric patients. Current Therapeutic Research Clinical and Experimental 2008, 69: Łyżeń R, Kchanwska M, Węgrzyn G, Szalewska-Pałasz A: IHF- and SeqA-binding sites, present in plasmid clning vectrs, may significantly influence activities f prmters. Plasmid 2008, 60:

13 222. Łś JM, Glec P, Węgrzyn G, Węgrzyn A, Łś M: Simple methd fr plating Escherichia cli bacteriphages frming very small plaques r n plaques under standard cnditins. Applied and Envirnmental Micrbilgy 2008, 74: Łś JM, Łś M, Węgrzyn A, Węgrzyn G: Rle f the bacteriphage ex-xis regin in the virus develpment. Flia Micrbilgica 2008, 53: Basselet P, Węgrzyn G, Enfrs S-O, Gabig-Cimińska M: Sample prcessing fr DNA chip arraybased analysis f enterhemrrhagic Escherichia cli (EHEC). Micrbial Cell Factries 2008, 7: De Felice M, Mattanvich D, Papagianni M, Wegrzyn G, Villaverde A: The scientific impact f micrbial cell factries. Micrbial Cell Factries 2008, 7: Pitrwska E, Jakóbkiewicz-Banecka J, Tylki-Szymańska A, Czartryska B, Węgrzyn A, Węgrzyn G: Crrelatin between severity f mucplysaccharidses and cmbinatin f the residual enzyme activity and efficiency f glycsaminglycan synthesis. Acta Paediatrica 2009, 98: Wang Z, Jin L, Yuan Z, Węgrzyn G, Węgrzyn A: Classificatin f plasmid vectrs using replicatin rigin, selectin marker and prmter as criteria. Plasmid 2009, 61: Królicka A, Szpitter A, Maciąg M, Biskup E, Gilgenast E, Rmanik G, Kamiński M, Węgrzyn G, Łjkwska E: Antibacterial and antixidant activity f the secndary metablites frm in vitr cultures f Drsera alicie. Bitechnlgy and Applied Bichemistry 2009, 53: Sawuła W, Banecka-Majkutewicz Z, Kadziński L, Jakóbkiewicz-Banecka J, Węgrzyn G, Nyka W, Banecki B: Hmcysteine level and metablism in ischemic strke in the ppulatin f Nrthern Pland. Clinical Bichemistry 2009, 42: Jakóbkiewicz-Banecka J, Pitrwska E, Narajczyk M, Barańska S, Węgrzyn G: Genistein-mediated inhibitin f glycsaminglycan synthesis, which crrects strage in cells f patients suffering frm mucplysaccharidses, acts by influencing an epidermal grwth factrdependent pathway. Jurnal f Bimedical Science 2009, 16: Wang Z, Jin L, Węgrzyn G, Węgrzyn A A nvel methd fr screening the glutathine transferase inhibitrs. BMC Bichemistry 2009, 10: Mazur-Marzec H, Truńska A, Błńska MJ, Mskt M, Pliński M, Jakóbkiewicz-Banecka J, Węgrzyn G: Bidegradatin f ndularin and effects f the txin n bacterial islates frm the Gulf f Gdańsk. Water Research 2009, 43: Malinwska M, Wilkinsn FL, Bennett W, Langfrd-Smith KJ, O Leary HA, Jakóbkiewicz-Banecka J, Wynn R, Wraith JE, Węgrzyn G, Bigger BW: Genistein reduces lyssmal strage in peripheral tissues f Mucplysaccharide IIIB mice. Mlecular Genetics and Metablism 2009, 98: Nejman B, Łś JM, Łś M, Węgrzyn G, Węgrzyn A: Plasmids derived frm lambdid bacteriphages as mdels fr studying replicatin f mbile genetic elements respnsible fr prductin f Shiga txins by pathgenic Escherichia cli strains. Jurnal f Mlecular Micrbilgy and Bitechnlgy 2009, 17: Łyżeń R, Kchanwska M, Węgrzyn G, Szalewska-Pałasz A: Transcriptin frm bacteriphage pr prmter is regulated independently and antagnistically by DksA and ppgpp. Nucleic Acids Research 2009, 37: Grabwski J, Węgrzyn G, Ktlarska E, Kwaterska M: Wzrst kultury mikrrganizmów w warunkach inhibicji. Inżynieria i Aparatura Chemiczna 2009, 3: Łś JM, Łś M, Węgrzyn G, Węgrzyn A: Differential efficiency f inductin f varius lambdid prphages respnsible fr prductin f Shiga txins in respnse t different inductin agents. Micrbial Pathgenesis 2009, 47: Plata K, Rsat AE, Węgrzyn G: Staphylcccus aureus as an infectius agent: verview f bichemistry and mlecular genetics f its pathgenicity. Acta Bichimica Plnica 2009, 56: Liberek A, Marek A, Kmieć Z, Kartanwicz D, Szlagatys-Sidrkiewicz A, Łuczak G, Wierzbicki PM, Stanisławwski M, Wierzbicki M, Marek K, Liberek T, Sikrska-Wiśniewska G, Góra-Gębka M, Węgrzyn G, Kamińska B: Rla transfrmująceg czynnika wzrstu 1 (TGF-1) w etipatgenezie i przebiegu klinicznym przewlekłych zapaleń wątrby u dzieci. Medycyna Wieku Rzwjweg 2009, XIII: Liberek A, Jakóbkiewicz-Banecka J, Klska A, Świderska J, Marek A, Łuczak G, Wierzbicki PM, Kmieć Z, Szlagatys-Sidrkiewicz A, Marek K, Sznurkwska K, Góra-Gębka K, Liberek T, Zagierski M, Kamińska B, Węgrzyn G: Plimrfizm genu transfrmująceg czynnika wzrstu 1 (TGF-1) w etipatgenezie i przebiegu klinicznym przewlekłych zapaleń wątrby u dzieci. Medycyna Wieku Rzwjweg 2009, XIII: Słczyńska K, Pękala E, Wajda A, Węgrzyn G, Marna H: Evaluatin f mutagenie and antimutagenic prperties f sme biactive xanthne derivatives using Vibri harveyi test. Letters in Applied Micrbilgy 2010, 50: Maciąg M, Kchanwska M, Łyżeń R, Węgrzyn G, Szalewska-Pałasz A: ppgpp inhibits the activity f Escherichia cli DnaG primase. Plasmid 2010, 63:61-67.

14 243. Pitrwska E, Jakóbkiewicz-Banecka J, Węgrzyn G: Different amunts f isflavnes in varius cmmercially available sy extracts in the light f gene expressin-targeted isflavne therapy. Phyttherapy Research 2010, 24:S109-S Dziedzic D, Węgrzyn G, Jakóbkiewicz-Banecka J: Impairment f glycsaminglycan synthesis in mucplysaccharidsis type IIIA cells by using sirna: a ptential therapeutic apprach fr Sanfilipp disease. Eurpean Jurnal f Human Genetics 2010, 18: Łś JM, Łś M, Węgrzyn A, Węgrzyn G Hydrgen perxide-mediated inductin f the Shiga txin-cnverting lambdid prphage ST in Escherichia cli O157:H7. FEMS Immunlgy and Medical Micrbilgy 2010, 58: Węgrzyn G, Jakóbkiewicz-Banecka J, Gabig-Cimińska M, Pitrwska E, Narajczyk M, Klska A, Malinwska M, Dziedzic D, Głębiewska I, Mskt M, Węgrzyn A: Genistein: a natural isflavne with a ptential fr treatment f genetic diseases. Bichemical Sciety Transactins 2010, 38: Glinkwska M, Łś JM, Szambwska A, Czyż A, Całkiewicz J, Herman-Antsiewicz A, Wróbel B, Węgrzyn G, Węgrzyn A, Łś M: Influence f the Escherichia cli xyr gene functin n prphage maintenance. Archives f Micrbilgy 2010, 192: Nadratwska-Wesłwska B, Słmińska-Wjewódzka M, Łyżeń R, Węgrzyn A, Szalewska-Pałasz A, Węgrzyn G: Transcriptin regulatin f the Escherichia cli pcnb gene cding fr ply(a) plymerase I: rles f ppgpp, DksA and sigma factrs. Mlecular Genetics and Genmics 2010, 284: Węgrzyn G, Jakóbkiewicz-Banecka J, Narajczyk M, Wiśniewski A, Pitrwska E, Gabig-Cimińska M, Klska A, Słmińska-Wjewódzka M, Krzn-Burakwska A, Węgrzyn A: Why are behavirs f children suffering frm varius neurnpathic types f mucplysaccharidses different? Medical Hyptheses 2010, 75: Glec P, Wiczk A, Majchrzyk A, Łś JM, Węgrzyn G, Łś M: A rle fr accessry genes ri.-1 and ri.1 in the regulatin f lysis inhibitin (LIN) by bacteriphage T4. Virus Genes 2010, 41: Łś M, Kuzi J, McCnnell MR, Krpinski AM, Węgrzyn G, Christie GE: Lysgenic cnversin in bacteria f imprtance t the fd industry. W: Bacteriphage in the Detectin and Cntrl f Fdbrne Pathgens (M. P. Sabur, M. Griffiths, Red.) 2010, American Sciety fr Micrbilgy Press, Washingtn D.C., USA, str Malinwska M, Wilkinsn FL, Langfrd-Smith KJ, Langfrd-Smith A, Brwn JR, Crawfrd BE, Vanier MT, Grynkiewicz G, Wynn RF, Wraith JE, Węgrzyn G, Bigger BW: Genistein imprves neurpathlgy and crrects behaviur in a muse mdel f neurdegenerative metablic disease. PLS ONE 2010, 5:e Węgrzyn G: Zmiany behawiralne i neurdegeneracyjne u dzieci chrych na różne typy mukplisacharydz. W: Neurnalne ścieżki pznania i zachwania, rzważania interdyscyplinarne (K. Jdzi, E. M. Szepietwska, Red.) 2010, Wydawnictw Uniwersytetu Marii Curie-Skłdwskiej, Lublin, str Węgrzyn G: Genetyka a bliźnięta. W: Rzwój bliźniąt w ciągu życia aspekty bipsychlgiczne (T. Rstwska, B. Pastwa-Wjciechwska, Red.) 2010, Oficyna Wydawnicza Impuls, Kraków, str Ktlarska E, Pdgórska B, Węgrzyn G, Niemirycz E, Blałek J: Testy mikrbilgiczne. W: Fizyczne, bilgiczne i chemiczne badania mrskich sadów dennych (J. Blałek, Red.) 2010, Wydawnictw Uniwersytetu Gdańskieg, Gdańsk, str Klska A, Jakóbkiewicz-Banecka J, Tylki-Szymańska A, Czartryska B, Węgrzyn G: Female Hunter syndrme caused by a single mutatin and familial XCI skewing: implicatins fr ther X- linked disrders. Clinical Genetics 2011, 80: Wenne R, Handschuh L, Pćwierz-Ktus A, Urbaniak R, Frmanwicz P, Całkiewicz J, Brzzwska K, Figlerwicz M, Węgrzyn G, Wróbel B: The applicatin f micrarray technlgy t the identificatin f Tc1-like element sequences in fish genmes. Marine Bilgy Research 2011, 7: Prnicka E, Węglewska-Jurkiewicz A, Prnicki M, Sykut-Cegielska J, Kwalski P, Pajdwska M, Jankwska I, Ktulska K, Kaliciński P, Jakóbkiewicz-Banecka J, Węgrzyn G: Drug-resistant epilepsia and fulminant valprate liver txicity: Alpers-Huttenlcher syndrme in tw children cnfirmed pst mrtem by identificatin f p.w748s mutatin in POLG gene. Medical Science Mnitr 2011, 17:CR Glec P, Wiczk A, Łś JM, Knpa G, Węgrzyn G, Łś M: Persistence f bacteriphage T4 in a starved Escherichia cli culture: evidence fr the presence f phage subppulatins. Jurnal f General Virlgy 2011, 92: Glec P, Dąbrwski K, Hejnwicz M, Gzdek A, Łś JM, Węgrzyn G, Łbcka M, Łś M: A reliable methd fr strage f tailed phages. Jurnal f Micrbilgical Methds 2011, 84: Klska A, Jakóbkiewicz-Banecka J, Narajczyk M, Banecka-Majkutewicz Z, Węgrzyn G: Effects f flavnids n glycsaminglycan synthesis: implicatins fr substrate reductin therapy in Sanfilipp disease and ther mucplysaccharidses. Metablic Brain Disease 2011, 26, 1-8.

15 262. Szambwska A, Pierechd M, Węgrzyn G, Glinkwska M: Cupling f transcriptin and replicatin machineries in the λ DNA replicatin initiatin: evidence fr direct interactin f Escherichia cli RNA plymerase and the O prtein. Nucleic Acids Research 2011, 39: Nejman B, Nadratwska-Wesłwska B, Szalewska-Pałasz A, Węgrzyn A, Węgrzyn G: Replicatin f plasmids derived frm Shiga txin-cnverting bacteriphages in starved Esherichia cli. Micrbilgy 2011, 157: Klawitter E, Kunikwska D, Tkarska-Pietrzak E, Dziadziuszk H, Łś JM, Glec P, Węgrzyn G, Łś M: Specific detectin f Salmnella enterica and Escherichia cli strains by using ELISA with bacteriphages as recgnitin agents. Eurpean Jurnal f Clinical Micrbilgy and Infectius Diseases 2011, 30: Prnicka E, Węglewska-Jurkiewicz A, Taybert J, Prnicki M, Szymańska-Dębińska T, Karkucińska- Więckwska A, Jakóbkiewicz-Banecka J, Kwalski P, Piekutwska-Abramczuk D, Pajdwska M, Scha P, Sykut-Cegielska J, Węgrzyn G: Pst mrtem identificatin f dexyguansine kinase gene (DGUOK) mutatins cmbined with impaired glucse hestasis and irn verlad features in fur infants with severe prgressive liver failure. Jurnal f Applied Genetics 2011, 52: Szalewska-Pałasz A, Ptrykus K, Cashel M, Węgrzyn G: Starvatin f bacteria fr amin acids as an example f prkarytic respnse t nutritinal deprivatin. W: Bilgy f Starvatin in Humans and Other Organisms (T. C. Merkin, Red.) 2011, Nva Science Publishers, Inc., Hauppauge NY, USA, Pitrwska E, Jakóbkiewicz-Banecka J, Maryniak A, Tylki-Szymańska A, Puk E, Liberek A, Węgrzyn A, Czartryska B, Słmińska-Wjewódzka M, Węgrzyn G: Tw years fllw-up f Sanfilipp disease patients treated with a genistein-rich isflavne extract: assessment f effects n cgnitive functins and general status f patients. Medical Science Mnitr 2011, 17:CR Jurecka A, Rzdzynska A, Marucha J, Czartryska B, Węgrzyn G, Tylki-Szymańska A: Natural histry f Plish patients with mucplysaccharidsis type VI. Central Eurpean Jurnal f Medicine 2011, 6: Skłwska I, Wälchli S, Węgrzyn G, Sandvig K, Słmińska Wjewódzka M: A single pint mutatin in ricin A-chain increases txin degradatin and inhibits EDEM1-dependent ER retrtranslcatin. Bichemical Jurnal 2011, 436: Maciąg M, Nwicki D, Janniere L, Szalewska-Pałasz A, Węgrzyn G: Genetic respnse t metablic fluctuatins: crrelatin between central carbn metablism and DNA replicatin in Escherichia cli. Micrbial Cell Factries 2011, 10: Tmatsu S, Mntan AM, Ssa-Mlan AC, Gutierrez-Carvalh C, Federhen A, Alves-Vieira T, Giugliani R, Węgrzyn G, Tanaka A, Suzuki Y, Orii T: Enzyme replacement therapy fr lyssmal strage diseases. W: Neurchemistry f Metablic Diseases (S. Surendran, Red.) 2011, Nva Science Publishers, Inc., Hauppauge NY, USA, rzdział Klska A, Tylki-Szymańska A, Węgrzyn G: Lizsmalne chrby spichrzeniwe - gólna charakterystyka. Pstępy Bichemii 2011, 57: Klska A, Tylki-Szymańska A, Węgrzyn G: Mukplisacharydzy bichemiczne mechanizmy chrób raz mżliwści terapeutyczne. Pstępy Bichemii 2011, 57: Marucha J, Tylki-Szymańska A, Jakóbkiewicz-Banecka J, Pitrwska E, Klska A, Czartryska B, Węgrzyn G: Imprvement in the range f jint mtin in seven patients with mucplysaccharidsis type II during experimental gene expressin-targeted isflavne therapy (GET IT). American Jurnal f Medical Genetics A 2011, 155: Langfrd-Smith A, Malinwska M, Langfrd-Smith K, Wegrzyn G, Jnes S, Wynn R, Wraith JE, Wilkinsn F, Bigger B: Hyperactive behaviur in the muse mdel f Mucplysaccharidsis IIIB in the pen field and hme cage envirnments. Genes, Brain and Behavir 2011, 10: Łś JM, Łś M, Węgrzyn G: Bacteriphages carrying Shiga txin genes: genmic variatins, detectin and ptential treatment f pathgenic bacteria. Future Micrbilgy 2011, 6: Jakóbkiewicz-Banecka J, Pitrwska E, Gabig-Cimińska M, Brysiewicz E, Słmińska-Wjewódzka M, Narajczyk M, Węgrzyn A, Węgrzyn G: Substrate reductin therapies fr mucplysaccharidses. Current Pharmaceutical Bitechnlgy 2011, 12: Dmchwska B, Pisik J, Wziwdzka A, Sikra K, Wiśniewski A, Węgrzyn G: Mutagenicity f quaternary ammnium salts cntaining carbhydrate mieties. Jurnal f Hazardus Materials 2011, 193: Łś JM, Węgrzyn G: Enterkrwtczne szczepy Escherichia cli (EHEC) i bakterifagi kdujące tksyny Shiga. Pstępy Mikrbilgii 2011, 50: Liberek A, Jakóbkiewicz-Banecka J, Klska A, Świderska J, Kmieć Z, Łuczak G, Wierzbicki P, Liberek T, Marek K, Plata-Nazar K, Sikrska-Wiśniewska G, Kamińska B, Węgrzyn G: Clinical parameters f inflammatry bwel disease in children d nt crrelate with fur cmmn plymrphisms f the transfrming grwth factr 1 gene. Acta Bichimica Plnica 2011, 58: Sikra K, Dmchwska B, Wziwdzka A, Pisik J, Węgrzyn G, Wiśniewski A: O brmkach D- glikpiranzyd-2-amnietylu. W: Na pgraniczu chemii i bilgii (H. Krniak, J. Barciszewski,

16 Red.) 2011, Wydawnictw Nukwe Uniwersytetu im. Adama Mickiewicza w Pznaniu, tm XXVII, str Nejman-Faleńczyk B, Glec P, Maciąg M, Węgrzyn A, Węgrzyn G: Inhibitin f develpment f Shiga txin-cnverting bacteriphages by either treatment with citrate r amin acid starvatin. Fdbrne Pathgens and Disease 2012, 9: de Ruijter J, Valstar MJ, Narajczyk M, Węgrzyn G, Kulik W, Ijlst L, Wagemans T, van der Wal WM, Wijburg FA: Genistein in Sanfilipp disease: a randmized cntrlled crss-ver trial. Annals f Neurlgy 2012, 71: Malinvá V, Węgrzyn G, Narajczyk M: The use f elevated dses f genistein-rich sy extract in the gene expressin-targeted isflavne therapy (GET IT) fr Sanfilipp disease patients. Jurnal f Inherited Metablic Disease Reprts 2012, 5: Krzn-Burakwska A, Jakóbkiewicz-Banecka J, Fiedsiuk A, Petrva N, Kblik T, Gabig-Cimińska M, Edmnds M, Małecki MT, Węgrzyn G: Osteprtegerin gene plymrphism in diabetic Charct neurarthrpathy. Diabetic Medicine 2012, 29: Jurecka A, Pitrwska E, Cimbalistiene L, Gusina N, Sbczyńska A, Czartryska B, Czerska K, Õunap K, Węgrzyn G, Tylki-Szymańska A: Mlecular analysis f mucplysaccharidsis type VI in Pland, Belarus, Lithuania and Estnia. Mlecular Genetics and Metablism 2012, 105: Maciąg M, Nwicki D, Szalewska-Pałasz A, Węgrzyn G: Central carbn metablism influences fidelity f DNA replicatin in Escherichia cli. Mutatin Research 2012, 731: Gabig-Cimińska M, Jakóbkiewicz-Banecka J, Węgrzyn G: DNA array. W: Handbk f Fd Safety Engineering (Da-Wen Sun, Red.) 2012, Blackwell Publishing Ltd., str Węgrzyn G, Licznerska K, Węgrzyn A: Phage - new insights int regulatry circuits. Advances in Virus Research 2012, 82: Łś M, Węgrzyn G: Pseudlysgeny. Advances in Virus Research 2012, 82: Kluk A, Łś M, Węgrzyn G: An imprved methd fr efficient islatin and purificatin f genmic DNA frm filamentus cyanbacteria belnging t genera Anabaena, Ndularia and Nstc. Oceanlgical and Hydrbilgical Studies 2012, przyjęta d druku Maciąg-Drszyńska M, Ignatwska M, Janniere L, Węgrzyn G, Szalewska-Pałasz A: Mutatins in central carbn metablism genes suppress defects in nucleid psitin and cell divisin f replicatin mutants in Escherichia cli. Gene 2012, 503: Liberek A, Kmieć Z, Kartanwicz D, Wierzbicki PM, Stanisławwski M, Kaszubwska L, Łuczak G, Góra- Gębka M, Landwski P, Szlagatys-Sidrkiewicz A, Liberek T, Kamińska B, Jakóbkiewicz-Banecka J, Węgrzyn G: The mrna level f the transfrming grwth factr 1 gene, but nt the amunt f the gene prduct, can be cnsidered as a ptential prgnstic parameter in inflammatry bwel diseases in children. Internatinal Jurnal f Clrectal Disease 2012, przyjęta d druku Narajczyk M, Tylki-Szymańska A, Węgrzyn G: Changes in hair mrphlgy as a bimarker in gene expressin-targeted isflavne therapy fr Sanfilipp disease. Gene 2012, 504: Banecka-Majkutewicz Z, Jakóbkiewicz-Banecka J, Gabig-Cimińska M, Węgrzyn A, Węgrzyn G: Putative bilgical mechanisms f efficiency f substrate reductin therapies fr mucplysaccharidses. Archivum Immunlgiae et Therapiae Experimentalis 2012, przyjęta d druku Klska A, Narajczyk M, Jakóbkiewicz-Banecka J, Grynkiewicz G, Szeja W, Gabig-Cimińska M, Węgrzyn G: Synthetic genistein derivatives as mdulatrs f glycsaminglycan strage. Jurnal f Translatinal Medicine 2012, 10: Glec P, Karczewska-Glec J, Łś M, Węgrzyn G: Nvel ZnO-binding peptides btained by the screening f a phage display peptide library. Jurnal f Nanparticle Research 2012, 14: Mskt M, Ktlarska E, Jakóbkiewicz-Banecka J, Gabig-Cimińska M, Fari K, Węgrzyn G, Wróbel B: Metal and antibitic resistance f bacteria islated frm the Baltic Sea. Internatinal Micrbilgy 2012, 15: Jurecka A, Żuber Z, Opka-Winiarska V, Węgrzyn G, Tylki-Szymańska A: Effect f rapid cessatin f enzyme replacement therapy: a reprt f 5 cases and a review f the literature. Mlecular Genetics and Metablism 2012, 107: Publicatins (summary): Jurnal: Publicatins number: Acta Bichimica Plnica Acta Paediatrica.. 1 Advances in Virus Research. 2 American Jurnal f Medical Genetics. 3

17 Analytical Bichemistry... 2 Annales Academiae Medici Gedanensis... 1 Annals f Neurlgy. 1 Antimicrbial Agents and Chemtherapy... 1 Applied and Envirnmental Micrbilgy... 2 Archives f Micrbilgy... 9 Archives f Virlgy... 1 Archivum Immunlgiae et Therapiae Experimentalis.. 1 BMC Bichemistry. 1 BMC Bitechnlgy... 2 BMC Pediatrics... 1 Bichemical and Biphysical Research Cmmunicatins... 7 Bichemical Jurnal... 4 Bichemical Sciety Transactins.. 1 Bichimie... 2 Bilgia. 1 Birganic and Medicinal Chemistry... 1 Birganic Chemistry 1 Bisensrs and Bielectrnics... 1 BiTech Internatinal... 1 Bitechnlgy and Applied Bichemistry.. 1 Bitechnlgy Letters... 3 Bitechnlgy Techniques... 1 Bulletin f Envirnmental Cntaminatin and Txiclgy... 1 Bulletin f the Plish Academy f Sciences - Bilgical Sciences... 1 Cellular and Mlecular Bilgy Letters... 1 Central Eurpean Jurnal f Medicine.. 1 Clinical Bichemistry. 1 Clinical Genetics. 1 Crustaceana... 1 Current Micrbilgy... 3 Current Nanscience. 1 Current Pharmaceutical Bitechnlgy 1 Current Therapeutic Research.. 1

18 Current Tpics in Virlgy... 1 Current Trends in Micrbilgy... 1 Diabetic Medicine... 1 Diagnstic Mlecular Pathlgy.. 2 Ectxiclgy and Envirnmental Safety. 1 Edukacja Bilgiczna i Śrdwiskwa. 1 EMBO Jurnal... 1 EMBO Reprts... 1 Envirnmental Mnitring and Assessment.. 1 Essentia Medica. 1 Eurpean Jurnal f Clinical Micrbilgy and Infectius Diseases 1 Eurpean Jurnal f Human Genetics.. 2 Eurpean Jurnal f Pediatrics. 1 Experimental Parasitlgy... 1 FEBS Letters... 3 FEMS Immunlgy and Medical Micrbilgy 2 FEMS Micrbilgy Letters... 9 FEMS Micrbilgy Reviews... 1 Flia Micrbilgica. 1 Fdbrne Pathgens and Disease 1 Future Micrbilgy.. 1 Gene... 4 Genes, Brain and Behavir 1 Genes t Cells... 1 Genetics... 2 Internatinal Archives f Biscience... 1 Internatinal Jurnal f Clrectal Disease.. 1 Internatinal Micrbilgy. 1 Inżynieria i Aparatura Chemiczna 1 Jurnal f Applied Genetics Jurnal f Applied Micrbilgy... 1 Jurnal f Bacterilgy... 4 Jurnal f Basic Micrbilgy... 3 Jurnal f Bilgical Chemistry... 3

19 Jurnal f Bimedical Science 1 Jurnal f Bitechnlgy... 2 Jurnal f General Virlgy.. 1 Jurnal f Hazardus Materials. 1 Jurnal f Inherited Metablic Disease. 1 Jurnal f Micrbilgical Methds... 1 Jurnal f Mlecular Bilgy... 4 Jurnal f Mlecular Micrbilgy and Bitechnlgy 1 Jurnal f Nanparticle Research.. 1 Jurnal f Translatinal Medicine. 1 Ksms... 2 Letters in Applied Micrbilgy... 3 Lichenlgist... 1 Luminescence... 1 Marine Bilgy Research 1 Marine Bitechnlgy... 1 Marine Pllutin Bulletin.. 1 Medical Hyptheses... 2 Medical Science Mnitr... 4 Medycyna Weterynaryjna... 1 Medycyna Wieku Rzwjweg.. 2 Metablic Brain Disease 1 Micrbial Cell Factries... 5 Micrbial Drug Resistance... 1 Micrbial Pathgenesis. 1 Micrbilgy Micrbilgical Research... 1 Mlecular and Cellular Prbes... 1 Mlecular and General Genetics Mlecular Bitechnlgy... 1 Mlecular Genetics and Genmics. 2 Mlecular Genetics and Metablism.. 3 Mlecular Micrbilgy... 4 Mutatin Reserach... 5

20 Myctaxn... 1 Nucleic Acids Research... 5 Oceanlgia... 1 Oceanlgical and Hydrbilgical Studies... 2 PharmaChem... 1 Phyttherapy Research 1 Plasmid PLS ONE 1 Plish Jurnal f Micrbilgy.. 1 Pstępy Bichemii... 8 Pstępy Bilgii Kmórki... 2 Pstępy Mikrbilgii 1 Praktyka i Klinika Medyczna.. 1 Prceedings f the Natinal Academy f Sciences f USA... 1 Prcess Bichemistry... 2 Prgress in Nucleic Acid Research and Mlecular Bilgy... 1 Recent Research Develpments in Virlgy... 1 Research in Micrbilgy... 1 Świat Meydcyny i Farmacji.. 1 Virlgy... 5 Virus Genes... 3 Water Research 1 Wrld Jurnal f Micrbilgy and Bitechnlgy 1 ROZDZIAŁY W KSIĄŻKACH summary 299