HTA. Evidence and value in decision-making paradigm. 12 th International Symposium Evidence-Based Health Care. Preliminary programme

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12 th International Symposium Evidence-Based Health Care December 11 th -12 th, 2017 Kraków, Poland HTA Evidence and value in decision-making paradigm Preliminary programme

Central and Eastern European Society of Technology Assessment in Health Care Ladies and Gentlemen, On behalf of CEESTAHC we are pleased to invite you to take part in the 12 th International Evidence-Based Health Care Symposium titled which will take place in Cracow, on 11 12 December 2017. Venue: Hotel Park Inn, Kraków, ul. Monte Cassino 2. Evidence-based health care is becoming a dominant direction for development of health care systems around the world. At the same time, thanks to greater awareness and increasing problems with interpreting results of studies and reviews, basic questions tend to be asked again. After so many years of EBHC development, we pose the question: what is evidence, anyway? We are searching for answers by starting with a single patient (e.g. in the case of rare diseases) and are going up to the level of the entire system with emphasis on what values and effects we want to achieve. We wish to invite you to yet another edition of our Symposium, which is intended as a starting point for a discussion on solutions created both in Poland and elsewhere in the world. Currently, many countries are either analysing phenomena or are already taking actions in areas which we discuss in our sessions: Developing value-based health care systems, Changing our approach towards obtaining marketing authorisations for drugs based on adaptive pathways; challenges faced by payers in Europe, Comprehensiveness and integration of care in the health care system, Introducing new medical devices and methods of their financing, Clinical guidelines how they are created, implemented and how do they impact the system, The situation and role of rare diseases including in particular the active attitude of patients and the solutions they prefer. Invitiation

2017 December 11 th -12 th, Kraków, Poland The market of medicinal products, medical devices and all health services is becoming more and more complicated. In this multilevel structure we encounter both cooperation and competition, and conflicts of interest are not always easy to identify. It seems obvious that the primary objective of health care should be meeting the health needs of the society, which can be done by way of prophylaxis, treatment and monitoring. Each country searches for optimal solutions which would keep up with the ever-changing surroundings and possibilities (and costs) brought about by new solutions. The aim of this Symposium is to ask: what should the shape of the system be? how should it be financed? and most of all: what should serve as the basis for its evaluation: costs, effects, values, or political objectives? We will also attempt to find an answer to these questions together. Furthermore, we will consider whether these questions can be used as a long-term indicator for the correct direction of development and when should they be adjusted? A hand-picked panel of experts from Poland and other countries will present the results of their studies and will suggest proposals of solutions in 6 sessions: 1. Directions of change in health care systems fee free session 2. Adapt or not to Adapt? Adaptive Pathways: a lifecycle approach in a sustainable way fee free session 3. New solutions in rare diseases 4. Is it necessary to regulate medical devices in the healthcare system? 5. Patient care integration management, financing evidence 6. Evidence synthesis and translation Representatives of the Polish and Belgian Ministries of Health have been invited to take part in the opening session. They will present their strategic goals and changes planned for the months and years to come. Belgium was one of the first countries in Europe to introduce a value-based systems several years back, therefore we are counting on honest reflections and first-hand experience. A broad group of stakeholders has been invited to participate in the session on adaptive pathways, including patients, representatives of registration offices and the European Medicines Agency in order to discuss problems and challenges faced by payers. Invitiation

Central and Eastern European Society of Technology Assessment in Health Care The Symposium also has the goal of supporting and educating the invited patient associations dealing with rare diseases. The session on rare diseases will present methods for measuring patients preferences and practical solutions developed in France which ensure comprehensiveness of treatment. The session on synthesis of evidence and creating guidelines will present the latest concepts. This session will demonstrate the latest Polish and Czech solutions and the years-long engagement of Cochrane, an international organisation, in the creation of credible methodology for systematic reviews. We are convinced that, despite many years of reform, it is necessary to continue the discussion on financing of services. Especially in view of such dynamic positive changes regarding the network of hospitals, medical devices, or integrated patient care. We hope that Polish and foreign examples of system solutions presented during the Symposium will constitute good starting points for an exchange of opinions. At the same time, in the session on medical devices, we will hold a panel discussion between representatives of the pharmaceutical industry, the public payer, experts in health care and clinicians. We want to treat our meeting at the 12th International Evidence-Based Health Care Symposium on 11-12 December 2017 as a chance for an exchange of views and a great opportunity to obtain information on detailed solutions in Poland and abroad. Join us at the Symposium! Invitiation Hotel Park Inn

2017 December 11 th -12 th, Kraków, Poland Central and Eastern European Society of Technology Assessment in Health Care (CEESTAHC) The Society was founded in Krakow in 2003. We associate professionals in the fields of HTA, economic and cost evaluations, EBM and quality assurance in clinical trials. Our main aim is development and progress of standards and methods of assessment of drug and non-drug health technologies in Central and Eastern Europe. Our additional goal is to develop and promote a common understanding and vocabulary, which allows various parties in the health care system to communicate: physicians, representatives of health insurance, medical societies, pharmaceutical companies, politicians, economists, hospital managers and other specialists who deal with financial aspects of medical services and assessment of both health care system quality and effectiveness of health technologies. Our further aim is to promote HTA and EBM in our part of Europe. We help especially those who has just begun with HTA we consult, organize training and offer other forms of support. Scientific Program Committee Magdalena Władysiuk Małgorzata Bała Maria Libura Ad R. Schuurman Mitchell Sugarman Brian Godman Local Organizing Committee Maciej Dziadyk Tomasz Jan Prycel Izabela Kukla Piotr Miazga Marcin Pająk CEESTAHC Starowislna 17 / 3, 31-038 Krakow, POLAND phone no. 12 357 76 34 fax no. 12 396 38 39 e-mail: office@ceestahc.org Bank account: PL 97 1240 4689 1111 0000 5142 0745 Swift code: PKOPPLPW Organizers

Central and Eastern European Society of Technology Assessment in Health Care Poniedziałek, 11 grudnia 2017 / Monday, December 11 th, 2017 9:30 15:50 Numer i tytuł sesji, temat wykładu / Session, lecture topic Sesja 1 / Session 1 Kierunki zmian w systemach ochrony zdrowia Directions of change in health care systems Zaproszeni prelegenci Invited speakers Czas trwania / Duration: 9.30-11.10 Wstęp wolny! / Fee free session! Moderator: Magdalena Władysiuk Otwarcie Sympozjum / Opening of the Symposium Magdalena Władysiuk 5 min. Polityka lekowa państwa w kierunku większej przewidywalności systemu / The national drug policy towards the system s greater predictability Rola i znaczenie programów pilotażowych, taryfikacji oraz procesu zmiany technologii medycznej w tworzeniu wykazu świadczeń gwarantowanych / The role and significance of pilot programmes, tariff-setting and the process of adapting health technologies in creating the list of guaranteed benefits Międzynarodowa współpraca w zakresie pricingu i refundacji leków: inicjatywa BeNeLuxA jako proof of concept International collaboration on pricing and reimbursement of pharmaceuticals: the BeNeLuxA Initiative as proof of concept Wartość jakości w systemie ochrony zdrowia zadania AOTMiT / The value of quality in the healthcare system tasks of AOTMiT, the Polish HTA Agency Marcin Czech Zbigniew Król Francis Arickx Roman Topór-Mądry 30 min. 15 min. Przerwa kawowa / Coffee-break 15 min. Sesja 2 / Session 2 Adaptować czy nie adaptować? Adaptive Pathways: jak w trwały sposób uwzględnić cykl życia leku? / Adapt or not to Adapt? Adaptive Pathways: a lifecycle approach in a sustainable way Czas trwania / Duration: 11.25-13.15* Wstęp wolny! / Fee free session! Moderator: Ad Schuurman Poniedziałek / Monday Przegląd programu adaptive pathways oraz platformy Adapt Smart / Overview of adaptive pathways and Adapt Smart Przemyślenia z perspektywy prawodawczej Reflections from a regulatory perspective André Broekmans Csilla Pozsgay 10 min.

2017 December 11 th -12 th, Kraków, Poland Poniedziałek, 11 grudnia 2017 / Monday, December 11 th, 2017 9:30 15:50 Numer i tytuł sesji, temat wykładu / Session, lecture topic Adaptive pathways perspektywa decydenta i płatnika publicznego / Adaptive pathways decision maker and public payer perspective Przemyślenia z perspektywy HTA Reflections from an HTA perspective Adaptive pathways jako zrównoważone podejście do cyklu życia leku oraz perspektyw pacjenta wizja Europejskiego Forum Pacjentów / Adaptive Pathways a balanced approach to life-cycle and patient Perspectives the vision of European Patients Forum Zaproszeni prelegenci Invited speakers Marcin Czech Magdalena Władysiuk Michał Rataj 10 min. 10 min. 10 min. Panel dyskusyjny / Discussion panel: André Broekmans, Marcin Czech, Vinciane Pirard, Csilla Pozsgay, Michał Rataj, Ad Schuurman i Magdalena Władysiuk Lunch 40 min. 45 min. Sesja 3 / Session 3 Nowe rozwiązania w chorobach rzadkich New solutions in rare diseases Moderator: Maria Libura Czas trwania / Duration: 14.00-15.50* 12 lat strategii na rzecz chorób rzadkich we Francji: co nowego? czego możemy się nauczyć? / A perspective from 12 years of strategy for rare diseases in France: what s new? what s inspirational? Wspólnoty pacjentów jako wspólnoty wiedzy. Jak wykorzystać je jako motor innowacji w chorobach rzadkich? / Patient communities as communities of knowledge. How can we use them to drive innovation in rare diseases? Znaczenie doboru punktów końcowych w badaniach klinicznych onkologia i hematoonkologia / The significance of endpoint selection for clinical trials oncology and hematooncology Value assessment (ocena wartościująca) leków sierocych w chorobach rzadkich / Value assessment of orphan drugs for rare diseases Myriam de Chalendar Maria Libura Anna Kordecka Steven Simoens Finansowanie leków sierocych w Europie / Financing of orphan drugs in Europe Robert Plisko * w czasy sesji wliczono czas dyskusji: 10 min. / discussion time included: 10 min. Poniedziałek / Monday

Central and Eastern European Society of Technology Assessment in Health Care Wtorek, 12 grudnia 2017 / Tuesday, December 12 th, 2017 9:00 15:25 Numer i tytuł sesji, temat wykładu / Session, lecture topic Sesja 5 / Session 5 Integracja opieki nad pacjentem zarządzenie, finansowanie, evidence / Patient care integration management, financing evidence Moderator: Magdalena Władysiuk Zaproszeni prelegenci Invited speakers Czas trwania / Duration: 9.00-10.30* Wczesna interwencja prezentacja wyników projektu międzynarodowego / Early Intervention presenting results of an international model Rehabilitacja lecznicza w Polsce kierunek zmian i rozwoju systemu / Medical rehabilitation in Poland the direction of changes and system development Wydatki, których nie widać analiza kosztów pośrednich na przykładzie przewlekłego wyprysku rąk / Expenses we do not notice an indirect cost analysis on the example of chronic hand eczema Międzyresortowa koordynowana opieka zdrowotna, propozycje rozwiązań na przykładzie SM / Interministerial coordinated care proposed solutions on the example of MS Magdalena Władysiuk Dominik Dziurda Paulina Rolska Andrzej Śliwczyński Przerwa kawowa / Coffee-break 10 min. Sesja 6 / Session 6 Evidence synteza i zastosowanie Evidence synthesis and translation Moderator: Magdalena Władysiuk Czas trwania / Duration: 10.40-12.25* Opracowywanie, adaptowanie i przyjmowanie wytycznych klinicznych: zastosowanie metodyki GRADE: Evidence-to- -Decision / Development, adaptation and adoption of clinical practice guidelines: Application of the GRADE Evidence- -to-decision framework Projekt narodowego centrum ds. wytycznych praktyki klinicznej w Czechach. Wykorzystywanie danych z przeglądów systematycznych w opracowywaniu wytycznych praktyki klinicznej / Project of national centre for Clinical Practice Guidelines in the Czech Republic; data from Systematic Reviews in development of Clinical Practice Guidelines Wojtek Wiercioch Miloslav Klugar Wtorek / Tuesday Wytyczne dla wytycznych praktyki klinicznych w Polsce Guidelines for creating clinical guidelines in Poland Dominik Dziurda

2017 December 11 th -12 th, Kraków, Poland Wtorek, 12 grudnia 2017 / Tuesday, December 12 th, 2017 9:00 15:25 Numer i tytuł sesji, temat wykładu / Session, lecture topic Making sense of the evidence a programme for developing enhanced HTA expertise in CEE / Jak korzystać z dowodów naukowych udoskonalenie oceny technologii medycznych w Europie Środkowo-Wschodniej Ocena błędu systematycznego w syntezie danych naukowych / Risk of bias assessment in evidence synthesis Zaproszeni prelegenci Invited speakers Alan Haycox Małgorzata Bała Lunch 15 min. 45 min. Sesja 4 / Session 4 Czy konieczne jest uregulowanie wyrobów medycznych w systemie ochrony zdrowia? Is it necessary to regulate medical devices in the healthcare system? Moderator: Mitch Sugarman Czas trwania / Duration: 13.10-15.25 Value-Based Health Care z perspektywy przemysłu Value-Based Health Care an industry perspective Wyroby medyczne dokąd zmierzamy Medical devices where are we headed? Finansowanie, refundacja, współpłacenie jak rozwiązać ten węzeł gordyjski? / Financing, reimbursement, co-payment how can this Gordian Knot be disentangled? Wpływ potencjalnych zmian finansowania wyrobów medycznych stosowanych w ramach świadczeń gwarantowanych na jakość, dostępność i bezpieczeństwo / The impact of potential changes in financing of medical devices applied as part of guaranteed benefits on quality, availability and safety Mitch Sugarman Ewa Warmińska Krzysztof Łanda Katarzyna Sabiłło 30 min. Panel dyskusyjny / Discussion panel: Krzysztof Łanda, Katarzyna Sabiłło, Mitch Sugarman, Wojciech Szefke, Bartosz Świdrak, Ewa Warmińska 30 min. * w czasy sesji wliczono czas dyskusji: 10 min. / discussion time included: 10 min. Wtorek / Tuesday

Central and Eastern European Society of Technology Assessment in Health Care Price table Price table (nett prices 23% VAT) Private sector Public institutions, NGOS, students and PhD students registration till November 30th 2017 1 day 570 60 2 days 645 85 registration from November 30th 2017 & during Symposium 1 day 600 145 2 days 685 200 Conditions of participation

2017 December 11 th -12 th, Kraków, Poland Conditions of participation 1. Variants of participation in the Symposium: 1 day 2 days two fee free sessions on December 11 th only 2. The cost of participation of one person depends on the time of declaration and the selected variant of participation (see the Price table for details). The number of places is limited. 3. The following participants are entitled to discounted fee: representatives of public institutions: a certificate must be produced on demand students and postgraduate students: based on the school s letter of reference (with official stamps) 4. The fee includes: participation in scientific sessions, educational materials, coffee breaks and the lunch. 5. Declaration may be submitted by: E-procurement system on our website Printed application form send by fax 6. Payment should be made within 7 days following acceptance of declaration (no later than 5 working days before commencement of the Symposium) to the following account: Bank PKO S.A O/Krakow Rynek Glowny 47, 30-960 Krakow, POLAND PL 97 1240 4689 1111 0000 5142 0745 Swift code: PKOPPLPW Payment title: EBHC Symposium 2017 + invoice ID 7. Cancellation. If participation is cancelled no later than December 4th, 2017, the cost of cancellation will be 30% of the fee; after that day the fee will not be returned. 8. The organisers reserve the right to change the Symposium programme. Conditions of participation

Central and Eastern European Society of Technology Assessment in Health Care Meet the Experts Gala dinner Join us at the Meet the Experts gala dinner and board the Alrina Theme of the meeting: Ahoy, sailors! When: Monday, 11 December 2017, 8 pm Where: Kurlandzki boulevard next to Father Bernatek Footbridge, Cracow The heart of Cracow, on the Vistula River, where Father Bernatek s Footbridge connects two districts, Kazimierz and Podgórze, is where Alrina a nineteenth century Dutch barge is moored. It is the oldest, the largest and the only barge of this kind in Poland. There are only three such vessels in the entire Europe. It is a real gem. Thanks to people who shared a passion for it, Alrina has been expertly renovated, and thus became special and one of a kind. Alrina, built in 1889, is truly unique. It is 53 meters long and has a very interesting past. Only three barges that size where built in Europe, and the Dutch felt that Alrina is so unique that it should be presented on their postage stamps. That is why when in 2003, after having been sold to a Polish company, and Alrina was leaving Rotterdam, a scandal broke out in the Netherlands and there was outrage that this precious historical specimen was being let out of the country. However, it was too late for controversies the antique barge already had a new owner and set off for a nearly 10-month (as it later turned out, bumpy) inland cruise towards Poland. One of such bumps included a situation at the Polish-German border, where the previous captain of the barge refused to disembark.

2017 December 11 th -12 th, Kraków, Poland The highlight of the evening, as legendary as the Arlina (although not as old), will be Mirek Koval Kowalewski a loveable Polish shantyman (who prefers the phrase swamp and marsh song performer, as he sings about inland, rather than marine sailing). Koval, along with the Zejman & Garkumpel band, are the authors of numerous sailing-themed songs and promoters of sailing among the young ones. Despite his notorious tendency to belittle his accomplishments and experiences, Mirek is also the author of columns in sailing magazines and an experienced sailor who, among others, sailed around Cape Horn. Alrina has undergone several years of renovation and was adapted for new purposes. The barge s traditional appearance was maintained with the beautiful curves of its sides and raised bow which is a rarity among other inland vessels. A roof was built over two holds, which were transformed into two rooms: a conference room and a restaurant, which is where a unique, sandbank-inspired bar is located. The original space division, with an elevated poop deck and a central platform was maintained on the main deck. The only change included added roofing, thanks to which the deck can be enjoyed even during winter. Meet the Experts Gala dinner

Central and Eastern European Society of Technology Assessment in Health Care Partners

N A V I G A R E 2017 December 11 th -12 th, Kraków, Poland N E C E S S E E S T, V I V E R E N O N E S T i t H TA A u d N E C E S S E Partners