P-gp inhibition (11-Me-Leu)-Cyclosporin A 1 1,2,3,4-Tetrahydro-1-methyl-6,7-isoquinolinediol 0 1,2,3,4-Tetrahydro-6,7-dimethoxy-isoquinoline 0

ligand P-gp inhibition (11-Me-Leu)-Cyclosporin A 1 1,2,3,4-Tetrahydro-1-methyl-6,7-isoquinolinediol 0 1,2,3,4-Tetrahydro-6,7-dimethoxy-isoquinoline 0 1,2,3,4-Tetrahydro-isoquinoline 0 1,3,5-Triazacycloheptane 4b 1 1,3,5-Triazacycloheptane 4c 1 1,3,5-Triazacycloheptane 5b 1 1,3,5-Triazacycloheptane 5c 1 1,3,5-Triazacycloheptane 5d 1 1,3,5-Triazacycloheptane 6b 1 1,3,5-Triazacycloheptane 6c 1 1-(3-methoxyphenyl)-N,N-dimethylmethanamine 0 1-(4-chlorbenzhydryl)piperazine 0 1-Benzyl-3-pyrroline 0 1-Benzylimidazole 0 1-Phenethylpiperidine 0 1-Phenylpiperazine 0 11-Deoxycortisol 1 14-Benzoylyohimbine 1 16-Dehydroprogesterone 1 16-Methylprogesterone 1 17-Hydroxypregnenolone 0 17-Hydroxyprogesterone 1 2,2'-Diphenylethylamine 0 2,4,6,8-Tetradiethano 0 2,4,6,8-Tetramopholin 0 2,4,6,8-Tetrapiperidy 0 2,4,6-Trimorpholinepy 0 2,4,8-Trimorpholinepy 0 2-Benzylpyridine 0 2-Chloro-10-[2-(dimethylamino)ethyl] phenothiazine 1 2-Chloro-10-[4-(dimethylamino)butyl] phenothiazine 1 2-Chloroimipramine 1 2-Oxazolidinone 0 3'-4'-Dichlorobenzamil 0 3,8-Dihydroxychlorpromazine 0 3-Methyl choroquine 1 4,8-Dipiperidyl-2,6-D 0 4,8-Dipiperidyl-2,6-M 0 4,8-Dipiperidyl-Dimet 0 4-(2-Dimethylamino)ethyl)morpholine 0 4-Androstene-3,17-dione 1 4-Hydroxytamoxifen 1 4-Hydroxytoremifene 1 4-Iodotamoxifen 1 4-beta-Phorbol 12,13-dibutyrate 1 4-beta-Phorbol 13-acetate 0 4-beta-Phorbol 13-butyrate 0 5-(N,N-hexamethylene)amiloride 0

5-(N-Methyl-N-isobutyl)amiloride 0 5-N-acetyl-8-demethylardeemin 1 5-N-acetylardeemin 1 5-[N-Methyl-N-(tert-butyl)]-amiloride 0 6-Phenyl-2,4,7-pterid 0 7,8-Dihydroxychlorpromazine 0 7-Hydroxychlorpromazine 0 AF-1393 1 AG-1112 0 AG-213 0 AG-690 1 AHC-52 1 AHR 06601 1 AHR 16462 1 AHR-16303 1 AN-989 1 AY 9944 1 Acapriazine 0 Acebutolol 0 Acecainide 0 Acepromazine 1 Aceprometazine 1 Acetophenazine 1 Acridine 0 Acridone-4-carboxamide 22 1 Acridone-4-carboxamide 23 1 Acridone-4-carboxamide 24 1 Acridone-4-carboxamide 28 1 Acridone-4-carboxamide 29 1 Acridone-4-carboxamide 30 1 Acridone-4-carboxamide 31 1 Acridone-4-carboxamide 32 1 Acridone-4-carboxamide 36 1 Acridone-4-carboxamide 39 1 Acridone-4-carboxamide 43 1 Acridone-4-carboxamide 44 1 Acridone-4-carboxamide 47 1 Acridone-4-carboxamide 48 1 Acridone-4-carboxamide 49 1 Acridone-4-carboxamide 50 1 Acridone-4-carboxamide 51 1 Acridone-4-carboxamide 52 1 Acridone-4-carboxamide 53 1 Acridone-4-carboxamide 54 1 Acridone-4-carboxamide 55 1 Acridone-4-carboxamide 59 1 Acridone-4-carboxamide 60 1 Acridone-4-carboxamide 61 1 Acridone-4-carboxamide 64 1 Acridone-4-carboxamide 65 1

Acridone-4-carboxamide 66 1 Acridone-4-carboxamide 67 1 Acridone-4-carboxamide 68 1 Acridone-4-carboxamide 69 1 Acridone-4-carboxamide 70 1 Acridone-4-carboxamide 71 1 Acridone-4-carboxamide 72 1 Acridone-4-carboxamide 73 1 Acridone-4-carboxamide 74 1 Acridone-4-carboxamide 75 1 Acridone-4-carboxamide 76 1 Acridone-4-carboxamide 77 1 Acridone-4-carboxamide 78 1 Acridone-4-carboxamide 79 1 Acridone-4-carboxamide 80 1 Acridone-4-carboxamide 81 1 Acridone-4-carboxamide 82 1 Acridone-4-carboxamide 83 1 Acridone-4-carboxamide 85 1 Acrivastine 0 Actinomycin D 0 Adiphenine 0 Aldicarb 0 Aldoxycarb 0 Aldrich 21430-2 1 Almitrine 1 Alpertine 1 Alpha-Tocopherol 0 Alprenolol 1 Alverine Amantadine 0 Ambodryl 0 Amiloride 0 Aminocarb 0 Aminopentamide 0 Amiodarone 1 Amitriptyline 1 Amlodipine 1 Amodiaquin 0 Amotriphene 1 Amoxapine 1 Amoxecaine 0 Amperozide 1 Amphotericin B 0 Amprenavir 1 Androstenedione 1 Androsterone 1 Antazoline 0 Antenolol 0 Antipyrine 0

Apomorphine 0 Aprindine 1 Ascorbic acid 0 Asocainol 1 Astemizole 1 Atorvastatin (methyl ester) 1 Atorvastatin lactone 1 Atrazine 0 Atropine 0 Aureobasidin A (ABA) 1 Azaclorazine 1 Azaconazole 0 Azaperone 0 Azelastine 1 Azidopine 1 Azidoprocainamide methoiodide 0 Azipramine 1 B3-243 1 B669 1 B9109-012 1 BIBW 22 1 BW 1019W91 1 BW 1136U89 1 BW 1288U89 1 BW 1351W91 1 BW 1379W91 1 BW 565C81 1 Bamipine 0 Barnidipine 1 Befuraline 0 Benactyzine 0 Bencyclane 0 Benidipine 1 Benzathine 1 Benzmalecene 0 Benzofuran derivative 2a 0 Benzofuran derivative 2c 1 Benzofuran derivative 2d 1 Benzofuran derivative 2e 1 Benzofuran derivative 2f 1 Benzquinamide 0 Benztropine 1 Bepridil 1 Berberine 0 Bevantolol 1 Bifonazole 1 Biperiden 0 Biphenamine 0 Biricodar 1 Bisobrin 0

Bleomycin A2 0 Boldine 0 Boxidine 0 Bromocriptine 1 Brompheniramine 0 Bryostatin 0 Bucainide 1 Buclizine 1 Budipine Buflomedil 0 Bufuralol 1 Bunaftine 1 Buspirone 1 Butalamine 0 Butaperazine 1 Buterizine 1 Butethamate 0 CP-100356 1 CP-101556 1 CP-114416 1 CP-114769 1 CP-117227 1 CP-12379 1 CP-141938 1 CP-147478 1 CP-69042 1 Calcimycin 0 Calphostin C 1 Captodiame Carbamazepine 0 Carbaryl 0 Carbinoxamine 1 Carbiphene 1 Carnitine 0 Caroverine 1 Carphenazine 1 Carvedilol 1 Carvedilol metabolite M2 0 Carvedilol metabolite M4 0 Carvedilol metabolite M5 0 Catharanthine 1 Cefoperazone 0 Cefotetan 0 Ceftazidime 0 Celiprolol 0 Cepharanthine 1 Cephradine 0 Cetiedil 1 Cetrizine 0 Chelerythrine 0

Chlophedianol 0 Chloracyzine 1 Chlorbenzoxamine 1 Chlorcyclizine 0 Chlorogenic acid 0 Chloropyramine 0 Chloroquine 0 Chlorpheniramine 0 Chlorphenoxamine Chlorproethazine 1 Chlorpromazine 1 Chlorprothixene 1 Chlorzoxazone 0 Chromonar Cimetidine 0 Cinchonidine 1 Cinepaxadil 1 Cinepazet 0 Cinepazic acid 0 Cinepazide 0 Cinnarizine 1 Cinprazole 1 Cinpropazide 0 Cintriamide 0 Cinuperone 1 Ciprofloxacin 0 Citalopram 0 Citatepine 1 Citenamide 0 Clamoxyquin 0 Clanobutin 0 Clebopride 0 Clemastine 1 Clemizole 1 Cletoquine 0 Clobutinol 0 Clocinizine 1 Clomestrone 0 Clomiphene 0 Clomipramine 1 Clonidine 0 Clopenthixol 1 Cloperastine 1 Clopimozide 1 Clopipazan 1 Clothiapine 1 Clothixamide 1 Clotrimazole 1 Colchicine 0 Colforsin 1

Coralyne 0 Corticosterone 0 Cortisone 0 Corynanthine 1 Coumaphos 1 Cryptophycin 1 Cyclobenzaprine 1 Cyclofenazine 1 Cyclopeptolide(1) 0 Cyclopeptolide(11) 0 Cyclopeptolide(12a) 1 Cyclopeptolide(12b) 1 Cyclopeptolide(15a) 1 Cyclopeptolide(15b) 1 Cyclopeptolide(16a) 1 Cyclopeptolide(16c) 1 Cyclopeptolide(16h) 1 Cyclopeptolide(18) 1 Cyclopeptolide(19) 0 Cyclopeptolide(2a) 1 Cyclopeptolide(2c) 1 Cyclopeptolide(2f) 1 Cyclopeptolide(3a) 1 Cyclopeptolide(3c) 1 Cyclopeptolide(3f) 1 Cyclopeptolide(3g) 1 Cyclopeptolide(3h) 1 Cyclopeptolide(3i) 1 Cyclopeptolide(3j) 1 Cyclopeptolide(3l) 1 Cyclopeptolide(3n) 1 Cyclopeptolide(4) 1 Cyclopeptolide(7) 1 Cyclopeptolide(8) 1 Cyclopeptolide(9) 1 Cyclophenazine 1 Cyclosporin A 1 Cyclosporin C 1 Cyclosporin G 1 Cypermethrin 1 Cyproheptadine 1 Cytochalasin A 0 Cytochalasin C 0 Cytochalasin D 0 Cytochalasin E 1 Cytochalasin H 0 Cytochalasin J 0 D490 1 D525 1 D528 0

D557 1 D559 1 D595 1 D784 1 D894 1 DDE 0 DDT 0 DHP-014 1 DMDP 1 DPDPE 0 Dagapamil 1 Danitracen 0 Dapiprazole 0 Darodipine 1 Debrisoquin 0 Dehydroemetine 0 Delavirdine 1 Delfantrine 0 Deltorphin II 0 Denzimol 0 Deoxycorticosterone 1 Desethylamiodarone 1 Desipramine 1 Desmethoxyyangonin 1 Desmethylazelastine 1 Desmethylchlorpromazine 0 Desmethylcitalopram 0 Desmethylsertraline 1 Devapamil 1 Dexamethasone 0 Dexniguldipine 1 Dialifos 0 Dibenzylamine 0 Dibozan 0 Dibucaine 1 Dicapthon 1 Diclofensine 0 Didesmethylchlorpromzine 0 Diethylaniline 0 Diethylstilbestrol 1 Difloxacin 0 Difluanine 1 Digoxin 0 Dihydroergotamine 0 Dihydromethysticin 1 Dihydropyridine DP11 1 Dihydropyridine DP5 1 Dihydropyridine DP6 1 Dihydropyridine DP7 1 Dihydropyridine DP9 1

Dihydropyrroloquinoline series 14 0 Dihydropyrroloquinoline series 27 1 Diisopromine Dilazep 1 Diltiazem 1 Dimethindene 1 Diosmetin 0 Diosmin 0 Diphenamid 0 Diphenazoline 0 Diphenidol 1 Diphenylpyraline 1 Disopyramide 0 Dixyrazine 1 Dobutamine 0 Doconazole 1 Domperidone 0 Doxapram 1 Doxazosin Doxepine 1 Doxorubicin 0 Doxylamine 0 Drobuline 1 Drofenine 0 Droloxifen 0 Droprenilamine 1 Droproizine 0 Duoperone 1 EKI-785 1 Ebastine 1 Econazole 0 Efonidipine 1 Eletriptan 0 Eltoprazine 0 Emepronium 0 Emetine 0 Emopamil 1 Enciprazine 1 Endosulfan 1 Enilconazole 0 Enoxacin 0 Epinephrine 0 Eprazinone 1 Eprozinol 1 Equilenine 0 Equilin 0 Ergocristine 1 Ergocryptine 1 Ergonovine 0 Ergotamine 1

Erythromycin 1 Estradiol 0 Estriol 0 Estrone 0 Etafenone 1 Ethylbenztropine 1 Ethylbenzylaniline 0 Etifelmin 0 Etodroxizine Etolotifene 1 Etomidoline 1 Etoposide 0 Euphodendroidin A 1 Euphodendroidin B 1 Euphodendroidin C 1 Euphodendroidin D 1 Euphodendroidin E 1 Euphodendroidin G 1 Euphodendroidin H 1 Euphodendroidin I 1 Euprocin 1 Falipamil 0 Famciclovir 0 Farnesyl analog AFCA 1 Farnesyl analog AFCMA 1 Farnesyl analog AFCME 1 Febuverine 1 Felodipine 1 Fenbutrazate 1 Fendiline 1 Fenoctimine 0 Fenoterol 0 Fenoxedil 1 Fenpipramide 0 Fenpiverinium 0 Fenticonazole 1 Fenvalerate 0 Fexofenadine 0 Filipin 0 Fisetin 0 Flavonoid ID 13 1 Flavonoid ID 21 0 Flavonoid ID 22 0 Flavonoid ID 23 0 Flavonoid ID 24 0 Flavonoid ID 37 1 Flavonoid ID 38 0 Fleroxacin 0 Flesinoxan 0 Flezelastine 1

Flordipine 1 Fluanisone 1 Fluazifop-butyl 0 Fluconazole 0 Flumazenil 0 Flunarizine 1 Fluoxetine 1 Fluperamide 1 Fluperlapine 1 Fluphenazine 1 Flurazepam 1 Fluspirilene 1 Fluvoxamine 1 GF120918 1 GGCME 1 GW 420867 1 Gallopamil 1 Gamfexine 0 Geldanamycin 1 Geldanamycin 17-AAG 1 Gepirone 0 Ginsenoside Rg3 1 Ginsenoside Rh2 1 Glaucine 1 Gramine 0 Guanabenz 0 Guanfacine 0 H-7 0 H-89 1 HA-1004 0 HDL-2722 0 Halopemide 1 Haloperidol 1 Hepzidine 1 Hexadiline 0 Hexobendine 1 Hexoprenaline 0 Histapyrrodine 0 Hoechst 33342 0 Homochlorocyclizine 0 Homofenazine Homoveratrylamine 0 Hoquizil 0 Hydramethylnon 1 Hydrastine 0 Hydrocotarnine 0 Hydromorphone 0 Hydroxyzine 1 Hyperforin 0 Idarubicin 1

Imatinib 1 Imiclopazine 0 Imipramine 1 Imolamine 0 Imoxiterol 0 Indinavir 0 Indomethacin 0 Isoconazole 1 Isoniazid 0 Isopromethazine 1 Isoxsuprine 0 Isradipine 1 Itraconazole Ivermectin Bla 1 Jatrophane diterpene(7) 1 Jatrophane diterpenoid(1) 1 Jatrophane diterpenoid(10) 1 Jatrophane diterpenoid(11) 1 Jatrophane diterpenoid(12) 1 Jatrophane diterpenoid(13) 1 Jatrophane diterpenoid(14) 1 Jatrophane diterpenoid(15) 1 Jatrophane diterpenoid(16) 1 Jatrophane diterpenoid(2) 1 Jatrophane diterpenoid(3) 1 Jatrophane diterpenoid(5) 1 Jatrophane diterpenoid(6) 1 Jatrophane diterpenoid(8) 1 Jatrophane diterpenoid(9) 1 K02 1 Keoxifene 0 Ketamine 0 Ketoconazole 1 Ketotifen 1 LR 764 0 LU43918 1 LU46324 1 LU47474 1 LU48895 1 LU49667 1 LU49940 1 LU51903 1 LY18947 0 LY292540 1 LY296097 1 LY335979 1 LY335983 1 LY350344 1 Labetalol 0 Laudanosine 1

Laudanosoline 0 Lenperone 1 Levodopa 0 Levophacetoperane 0 Lidocaine 0 Lidoflazine 1 Linadryl 1 Lindane 0 Lobeline 1 Lombazole Loperamide 1 Lopinavir 1 Loratadine 1 Lorcainide 1 Losartan 0 Lovastatin acid 0 Lovastatin lactone 1 Loxapine 1 Luteolin 0 Luteolin-4'-O-glucoside 0 MA 1499 1 MA 1509 1 MA 1510 1 MA 1586 1 MA 1588 1 MA 1598 1 MA 1813 1 MA 1862 0 MA 1865 0 MA 1880 0 MDL 6792 MDL-10393 MDL8917V 1 MDR reversal agent 15h 1 MDR reversal agent 15i 1 MDR reversal agent 15m 1 MDR reversal agent 15o 1 MDR reversal agent 15u 1 MDR reversal agent 15x 1 MDR reversal agent 28a 1 MDR reversal agent 28c 1 MDR reversal agent 35a 1 MDR reversal agent 35d 1 MDR reversal agent 37b 1 MER37 1 MK-571 0 MM36 1 MS-209 1 Macbecin II 1 Manidipine 1

Mannitol 0 Maprotiline 1 Maroxepine 0 Mebendazole 1 Mebeverine 1 Meclizine 1 Mecloxamine 0 Medroxyprogesterone 1 Medroxyprogesterone acetate 1 Mefloquine 1 Megestrol Acetate 1 Meglitinide 0 Memotine 0 Mephentermine 0 Mephenytoin 0 Mepramidil 1 Meprobamate 0 Mequitazine 1 Mesoridazine 1 Mesuprine 0 Metergoline 1 Methadone 1 Methaphenilene 0 Methdilazine 0 Methixene 0 Methomyl 0 Methotrimeprazine 1 Methoxychlor 0 Methoxypromazine Methyl Cellosolve Acetate 0 Methylamine 0 Methysergide 0 Methysticin 1 Metiapine 1 Metoclopramide 0 Metofenazate 1 Metopimazine 0 Metoprolol 0 Metoserpate 1 Metoxepin 1 Mevinphos 0 Mexilitene 0 Mezilamine 0 Mianserin 0 Mibefradil 1 Miconazole 0 Midazolam 1 Mifepristone (RU486) 1 Milenperone 1 Milipertine 1

Mioflazine 1 Mirex 0 Mitomycin C 0 Mitoxantrone 0 Mixidine 0 Moclobemide 0 Monensin 1 Mopidamol 0 Morin 0 Morphine 0 Motracetam 0 Moxapridine 1 N,N'-Diphenyl-p-phenylenediamine 0 N,N'-dibenzylethylene diamine 0 N,N-Bis(alkanol)amine aryl ester analog 21 1 N,N-Bis(alkanol)amine aryl ester analog 5 0 N,N-Bis(alkanol)amine aryl ester analog 6 1 N,N-Bis(alkanol)amine aryl ester analog 8 1 N,N-Bis(alkanol)amine aryl ester analog 9 1 N,N-Dimethylbenzylamine 0 N,N-bis(cyclohexanol)amine aryl ester (3) 1 N,N-bis(cyclohexanol)amine aryl ester (4) 1 N,N-bis-arylalkylamine derivative(1) 1 N,N-bis-arylalkylamine derivative(2) 1 N,N-diethylcyclohexylamine 0 N-Benzylbenzamide 0 N-Methyl-gallopamil 0 N-Norlaudanosine 1 N-Norlaudanosoline 0 N-Phenyl-1-naphthylamine 0 N-Phenyl-2-naphthylamine 0 N-acetyl-daunorubicin 1 N-acyloxy-1,4-dihydropyridine(10) 1 N-acyloxy-1,4-dihydropyridine(5) 1 N-acyloxy-1,4-dihydropyridine(6) 1 N-acyloxy-1,4-dihydropyridine(7) 1 N-acyloxy-1,4-dihydropyridine(8) 1 N-acyloxy-1,4-dihydropyridine(9) 1 N-desmethyl-toremifene 1 N-desmethyl-venlafaxine 1 N-desmethyltamoxifen 1 N-trialkylglycine N31214C 1 NK-101 0 NK-106 1 NSC 102843 1 NSC 169647 0 NSC 220202 1 NSC 303594 1 NSC 30774 1 NSC 33128 1

NSC 344003 1 NSC 359449 0 NSC 633043 0 NSC 633320 0 NSC 640085 0 NSC 648114 1 NSC 649087 1 NSC 665333 1 NSC 666490 0 NSC 667739 1 NSC 668360 1 NSC 673413 0 NSC 676590 1 NSC 676591 1 NSC 676600 1 NSC 676605 1 NSC 88116 0 NSC 88657 0 NSC 94907 0 Nafcillin 0 Nafiverine 1 Nafoxidine 1 Naftifine 0 Naftopidil 1 Naftoxate 1 Nalbuphine 0 Naloxone 0 Naltrexone 0 Naltrindole 0 Nefazodone 1 Nelfinavir 1 Neostigmine 0 Nicardipine 1 Nicergoline 1 Nifedipine 1 Nilprazole 1 Niludipine 1 Nimodipine 1 Nisoldipine 1 Nitrazepam 0 Nitrendipine 1 Nitromifene 1 Nobiletin 1 Nomifensine 0 Nordazepam 0 Norfloxacin 0 Norfluxetine 1 Norgallopamil 1 Nortriptylene 1 Norverapamil 1

Noscapine 1 Nuclotixene 0 Nylidrin 0 O-desmethyl-venlafaxine 0 OBF-1622 0 OBF-1822 1 OBF-1834 0 OC144-093 1 OL-57 1 Ofloxacin 0 Oleanolic acid 0 Olivomycin A 0 Omeprazole 1 Omeprazole sulfone 0 Omoconazole 0 Opipramol 0 Opromazine 1 Orconazole Oxamarin 0 Oxatomide 1 Oxiconazole 0 Oxolinic acid 0 Oxprenolol 0 Oxybutynin 1 Oxyfedrine 0 Oxypendyl 0 Oxyperomide 0 Oxypertine 1 PAK-1 1 PAK-200 1 PAK-8 0 PGP-4008 1 Palmitoylcartinine 0 Papaverine 0 Paraquat 0 Parathion-methyl 1 Parconazole 0 Paroxetine 1 Pefloxacin 0 Penfluridol 1 Pentachlorophenol 0 Pentazocine 1 Peptoid 1 1 Peptoid 2 1 Peradoxime 1 Perafensine 0 Perazine Perhexilline 0 Perimetazine 1 Perlapine 1

Perphenazine 1 Phenethylamine 0 Pheniramine 0 Phenoxazine ID 11 1 Phenoxazine ID 12 1 Phenoxazine ID 15 0 Phenoxazine ID 18 1 Phenoxazine ID 2 1 Phenoxazine ID 3 1 Phenoxazine ID 4 1 Phenoxazine ID 5 1 Phenylamil 1 Phenyltoloxamine 0 Phenytoin 0 Phorbol 0 Phosmet 0 Physostigmine 1 Pifarnine 1 Piflutixol 1 Pimethixene 1 Pimozide 1 Pinafide 0 Pinoxepine 1 Pipamperone 1 Pipemidic Acid 0 Piperacetazine Piperamide 0 Piperdimerine A 1 Piperine 1 Pipoxizine 1 Pipoxolan 0 Pirenzepine 0 Pirohenptine 1 Piromidic Acid 0 Pirprofen 0 Pizotyline 1 Pramiverin 0 Pravastatin 0 Prazosin 1 Predifine 1 Pregnanedione 1 Prenoverine 0 Prenoxidiazine 1 Prenylamine 1 Primaquine 0 Primidolol 0 Prinixic acid 0 Pristinamycin IA 1 Proadifen 1 Prochlorperazine 1

Procyclidine 1 Prodipine Progabide 1 Progesterone 1 Promazine 0 Promethazine 1 Propafenone 1 Propafenone derivative 1b 1 Propafenone derivative 1c 1 Propafenone derivative 1e 1 Propafenone derivative 1f 1 Propafenone derivative 1g 1 Propafenone derivative 1i 1 Propafenone derivative 1k 1 Propafenone derivative GP01 1 Propafenone derivative GP02 1 Propafenone derivative GP03 0 Propafenone derivative GP05 1 Propafenone derivative GP07 0 Propafenone derivative GP10 0 Propafenone derivative GP134 1 Propafenone derivative GP155 1 Propafenone derivative GP159 1 Propafenone derivative GP163 1 Propafenone derivative GP164 1 Propafenone derivative GP17 0 Propafenone derivative GP240 1 Propafenone derivative GP29 1 Propafenone derivative GP31 1 Propafenone derivative GP339 1 Propafenone derivative GP358 1 Propafenone derivative GP359 1 Propafenone derivative GP360 1 Propafenone derivative GP366 1 Propafenone derivative GP381 1 Propafenone derivative GP388 1 Propafenone derivative GP389 0 Propafenone derivative GP46 0 Propafenone derivative GP57 1 Propafenone derivative GP62 1 Propafenone derivative GP88 1 Propafenone derivative GP90 1 Propafenone derivative ID 16 1 Propafenone derivative ID 17 1 Propafenone derivative ID 19 1 Propafenone derivative ID 20 1 Propafenone derivative ID 21 1 Propafenone derivative ID 22 1 Propafenone derivative ID 23 1 Propafenone derivative ID 24 1

Propafenone derivative ID 28 1 Propafenone derivative ID 29 1 Propafenone derivative ID 36 1 Propafenone derivative ID 37 1 Propafenone derivative ID 38 1 Propafenone derivative ID 39 1 Propafenone derivative ID 40 1 Propafenone derivative ID 7b 1 Propantheline 0 Propenzolate 1 Propericiazine 0 Propiconazole 0 Propoxur 0 Propoxyphene 1 Propranolol 1 Prothipendyl 0 Protokylol 0 Protriptyline 1 Proxazole 0 Prozapine Purine analog ID 17 1 Purine analog ID 18 1 Purine analog ID 24 1 Purine analog ID 26 1 Purine analog ID 28 1 Purine analog ID 3 1 Purine analog ID 32 1 Purine analog ID 4 1 Purine analog ID 5 1 Purine analog ID 7 1 Purine analog ID 8 1 Purine analog ID 9 1 Puromycin 0 Pyrathiazine 1 Pyrilamine 0 Quinacrine 1 Quinazosin 0 Quinidine 1 Quinupramine 1 Quipazine 0 R40 500 1 R41300 1 R42164 1 R49960 R59022 R6033 1 RA-134 1 RA-14 1 RA-158 0 RA-159 0

RA-168 1 RA-17 0 RA-171 1 RA-178 1 RA-19 1 RA-198 0 RA-24 1 RA-3 0 RA-4 0 RA-8 1 RA-83 0 RE-244 1 RE-28 1 RE-34 0 RE-38 1 RE-57 1 RE-61 1 RE-62 1 RE-66 0 RXRA-160 RXRA-642 1 RXRA-69 1 RXRE-104 1 RXRE-61 0 RXRE-62 0 RXRE-63 1 Racefemine 1 Racemethorphan 0 Ranitidine 0 Razinodil 1 Reboxetine 1 Rescinnamine 1 Reserpic acid 0 Reserpine 1 Revenast 1 Reversin 121 1 Reversin 205 1 Rhoifolin 0 Rifampin 1 Rifamycin B 0 Rifamycin SV 0 Rilapine 1 Risperidone 1 Ritodrine 0 Ritonavir 1 Ro 4-1284 1 Ro-04-2249 1 Ro-04-2250 1 Ro-04-2285 1 Ro-04-2287 1

Ro-04-2359 1 Ro-04-2360 1 Ro-04-2669 1 Ro11-2933 1 Rolitetracycline 0 Ropitoin 1 Ropizine 1 Roxithromycin 1 Rythmol 1 S 9788 1 S-Farnesylcysteine 0 S76 5200 1 S78 5780 S78 5781 1 S79 0491 1 S79 0671 1 S79 1099 1 S79 1100 1 S79 2823 1 S81 0337 1 S81 0339 1 S81 1951 1 S83 4096 1 S83 4163 1 SCH66336 1 SDZ-PSC 833 1 SKF-16467 1 SKF-3301 SNC 121 0 SPS 1768 0 SPS 1769 1 SPS 1770 1 SPS 1772 1 SPS 1773 1 SPS 1774 1 SPS 1775 1 SPS 1776 1 SPS 1777 1 SPS 1778 1 SPS 1779 1 SPS 1793 1 SPS 1835 1 SPS 1836 0 SPS 1837 0 SPS 1838 1 SPS 1839 1 SPS 1840 1 SPS 1841 0 SPS 1842 1 SPS 1843 1

SPS 1844 1 SPS 1845 1 SPS 1846 1 SPS 1847 SPS 1848 0 SPS 1849 1 SPS 1850 1 SPS 1852 1 SPS 1853 1 SPS 1854 1 SZ48 1 Safingol 0 Salmeterol Salverine 0 Saquinavir 1 Scopolamine 0 Secoverine 1 Selegiline 0 Selparazine 1 Sertraline 1 Sesquiterpene(1) 1 Sesquiterpene(11) 1 Sesquiterpene(12) 1 Sesquiterpene(13) 1 Sesquiterpene(14) 1 Sesquiterpene(8) 1 Setastine 1 Silybin 1 Simetride 1 Simvastatin acid 0 Sirolimus 1 Sitagliptin 0 Solanesol 0 Solypertine 1 Spasmadryl 0 Spiramide 1 Spirilene 1 Strophanthidin 0 Sulconazole 0 Sulfasalazine 0 Sulfinpyrazone 0 Sulforidazine 1 Suloctidil 0 Sumatriptan 0 Suramin 0 Syrosingopine 1 T13 1 TMB8 1 TPP 0 TRX-13 0

Tacrine 0 Tacrolimus 1 Talinolol 0 Tamoxifen 1 Tampramine 1 Tangeretin 1 Tefludazine 1 Telithromycin 1 Terbinafine 0 Terconazole 1 Terfenadine 1 Terodiline 1 Teroxalene 1 Testosterone 1 Tetrabenazine 0 Tetrahydroquinoline ID 2a 1 Tetrahydroquinoline ID 2b 1 Tetrahydroquinoline ID 2f 1 Tetrahydroquinoline ID 2g 1 Tetrahydroquinoline ID 3f 1 Tetrahydroquinoline ID 3g 1 Tetraphenylphosphonium 0 Thalicarpine 1 Thenaldine 0 Thenyldiamine 0 Thiethylperazine 1 Thioproperazine 1 Thioridazine 1 Thonzylamine 0 Tiapamil 1 Tiaramide 0 Tilorone 0 Tilozepine 1 Tioconazole 0 Tiodazosin 0 Tioperidone 1 Tiopropamine Tiprenolol 0 Tipropidil 0 Tixadil 0 Tolamolol 0 Tolnapersine 1 Tolpropamine Tolyporphin A 1 Toprilidine 1 Toremifene 1 Trazodone 1 Tretoquinol 0 Tri-n-butylmethylamminiun 0 Triazine derivative ID 11 1

Triazine derivative ID 12 1 Triazine derivative ID 15 1 Triazine derivative ID 16 1 Triazine derivative ID 17 1 Triazine derivative ID 18 1 Triazine derivative ID 20 1 Triazine derivative ID 21 1 Triazine derivative ID 22 1 Triazine derivative ID 23 1 Triazine derivative ID 24 1 Triazine derivative ID 25 1 Triazine derivative ID 26 1 Triazine derivative ID 30 1 Triazine derivative ID 32 1 Triazine derivative ID 33 1 Triazine derivative ID 34 1 Triazine derivative ID 35 1 Triazine derivative ID 36 1 Triazine derivative ID 37 1 Triazine derivative ID 38 1 Triazine derivative ID 39 1 Triazine derivative ID 40 1 Triazine derivative ID 42 1 Triazine derivative ID 44 1 Triazine derivative ID 45 1 Triazine derivative ID 46 1 Triazine derivative ID 47 1 Triazine derivative ID 54 1 Triazine derivative ID 57 1 Triazine derivative ID 6 1 Triazine derivative ID 7 1 Triazine derivative ID 8 1 Triazine derivative ID 9 1 Triazolam 0 Trifluoperazine 1 Trifluperidol 1 Triflupromazine 1 Triforine 0 Trihexyphenidyl 0 Trimazosin 0 Trimebutine 1 Trimeprazine 0 Trimethoprim 0 Trimetozine 0 Trimipramine 1 Triparanol 1 Tripelennamine 0 Triprolidine 1 Tropirine 1 Troxonium 0

Trypan blue 0 Tryptanmine 0 Tryptophan 0 Tubulzole 0 U-69593 0 U10520A 1 U11555A 0 U18666A 1 UCB-26166 1 UCB-26359 1 UCB-J028 0 UCB-L172 1 UCB-N101 1 Urapidil 0 Valinomycin 1 Vancomycin 0 Venlafaxine 0 Verapamil 1 Verapamil analogue(19) 1 Verapamil analogue(2) 1 Verapamil analogue(25) 1 Verapamil analogue(29) 1 Verapamil analogue(4) 1 Verapamil analogue(5) 1 Vetrabutine 1 Vinblastine 1 Vinclozolin 0 Vincristine 0 Vindoline 1 Vitamin A palmitate 0 W-12 0 W-13 0 W-7 0 W2795 0 W8-032 1 Warfarin 0 XR9051 1 XR9576 1 Xenthiorate 0 Zimeldine 0 Zipeprol 1 Zolamine 0 Zolertine 0 Zolmitriptan 0 Zoloperone 0 Zolpidem 1 Zomepirac 0 cis-flupentixol 1 cis-thiothixene 1 o-nitropehenyl N,N-dimethylcarbamate 0

1-P-gp inhibitor 0-P-gp non-inhibitor tra96023 1