Bioanalytical Methods

LABORATORY SERVICES Bioanalytical Methods Our resources become yours. bdinfo@nuvisan.com www.nuvisan.com

LABORATORY SERVICES Bioanalytical Methods Acetaminophen 0.25 μg/ml Plasma LC/MS/MS Acetaminophen/Tramadol 100 / 5 ng/ml Plasma LC/MS/MS Albuterol 0.5 ng/ml Plasma GC/MS Aldosterone 25 pg/ml Serum ELISA Alendronate 1 / 0.5 ng/ml Urine/Plasma LC/MS/MS Alkaline Hematin (Menstrual Blood) 3 ml Feminine Hygeine Prod. Colorimetric Allopurinol / Oxypurinol 50 /100 ng/ml Plasma LC/MS/MS Alprazolam 50 pg/ml Plasma GC/MS Alprazolam 0.5 ng/ml Plasma LC/MS/MS Aluminum 5/2 ng/ml Plasma/Urine ICP/MS Amikacin 0.15 ug/ml Serum LC/MS/MS 5-Aminosalicylic acid/n-acetyl-5-aminosalicylic acid 10/20 ng/ml Plasma LC/MS/MS Amiodarone / Desethylamiodarone 10 / 10 ng/ml Plasma LC/MS/MS Amitriptyline 200 pg/ml Plasma LC/MS/MS Amlodipine 50 pg/ml Plasma LC/MS/MS Amphetamine 100 pg/ml Plasma/Serum GC/MS Articaine 10 ng/ml Plasma/Urine GC/MS Articainic Acid 20 ng/ml Plasma/Urine GC/MS Atenolol 10 ng/ml Plasma LC/MS/MS Atenolol 250 ng/ml Urine LC/MS/MS Atorvastatin/O-hydroxy/P-hydroxy atorvastatin 200/100/20 pg/ml Plasma LC/MS/MS Atropine 50 pg/ml Plasma GC/MS Atomoxetine 10 ng/ml Plasma LC/MS/MS Azathioprine/6-Mercaptopurine 1/1 ng/ml Plasma LC/MS/MS Azithromycin 2 ng/ml Plasma LC/MS/MS Benazepril / Benazeprilat 5 / 10 ng/ml Plasma LC/MS/MS Benidipine 50 pg/ml Plasma GC/MS Betahistine 5 pg/ml Plasma LC/MS/MS Betamethasone 50 pg/ml Plasma GC/MS Bicalutamide 2.5 ng/ml Plasma LC/MS/MS Biperiden 250 pg/ml Plasma GC/MS Bismuth 0.5 ng/ml Plasma ICP-MS Bisoprolol 0.2 ng/ml Plasma LC/MS/MS Boswellic Acid 50 ng/ml Plasma GC/MS Bromine 0.5 μg/ml Plasma ICP/MS Bromocriptine 2.5 pg/ml Plasma LC/MS/MS Brompheniramine 0.5 ng/ml Plasma LC/MS/MS Budesonide/16-OH Budesonide/16-OH Prednisolone 0.1/0.1/0.5 ng/ml Plasma LC/MS/MS Buprenorphine 25 pg/ml Plasma GC/MS Buprenorphine / Norbuprenorphine 5 / 5 pg/ml Plasma LC/MS/MS Buspirone / 1-PP 100 pg/ml Plasma LC/MS/MS Butorphanol 20 pg/ml Plasma LC/MS/MS Canrenone 2 ng/ml Plasma LC/MS/MS Canrenone 20 ng/ml Urine LC/MS/MS Capric Acid 100 ng/ml Plasma LC/MS/MS Carvedilol 0.1 ng/ml Plasma LC/MS/MS Cetirizine 2 ng/ml Plasma LC/MS/MS Chlorhexidine 25 ng/ml Saliva LC/MS/MS Chlormadinone Acetate 50 pg/ml Plasma GC/MS Citalopram 100 pg/ml Plasma LC/MS/MS Citric Acid 50 ng/ml Urine LC/MS/MS Clarithromycin 10 ng/ml Plasma LC/MS/MS This is not a complete list. Where higher levels are measured, only the lowest measure is shown.

Our recources become yours. Clemastine 100 pg/ml Plasma GC/MS Clenbuterol 0.2 ng/ml Plasma / Urine GC/MS Clindamycin 100 ng/ml Plasma LC/MS/MS Clonazepam 100 pg/ml Plasma LC/MS/MS Clonidine 25 pg/ml Plasma GC/MS Clozapine 0.1 ng/ml Plasma LC/MS/MS Codeine 1 ng/ml Plasma LC/MS/MS Cortisol 1 Ng/ml Plasma LC/MS/MS Cyclobenzaprine 0.1 ng/ml Plasma LC/MS/MS Cyclosporin 10 ng/ml Whole Blood LC/MS/MS Cyproterone Acetate 25 pg/ml Plasma/Serum GC/MS Desmopressin 2.5 pg/ml Plasma LC/MS/MS Desogestrel (3-keto-desogestrel) 25 pg/ml Plasma GC/MS Desogestrel (3-keto-desogestrel) /Ethinylestradiol 25/2.5 pg/ml Plasma GC/MS Dexamethasone 0.25 ng/ml Plasma LC/MS/MS Diclofenac 5 ng/ml Plasma LC/MS/MS Dienogest 0.5 ng/ml Plasma LC/MS/MS Digoxin 1 ng/ml Urine LC/MS/MS Digoxin 1 ng/ml Plasma LC/MS/MS Diltiazem / Desmethyldiltiazem / Desacetyldiltiazem 4/2/1 ng/ml Plasma LC/MS/MS Diphenydramine 1 ng/ml Plasma LC/MS/MS Disulfiram (as Methyl Diethydithiocarbamate) 1.0 ng/ml Plasma GC/MS Docetaxel 2.5 ng/ml Plasma LC/MS/MS Doxorubicin 1.5 ng/ml Urine LC/MS/MS Doxorubicin / Doxorubicinol 0.5 / 0.5 ng/ml Plasma LC/MS/MS Doxycycline 0.1 ng/ml Plasma LC/MS/MS Dronabinol/11-OH-Dronabinol 200/200 pg/ml Plasma LC/MS/MS Drospirenone 100 pg/ml Plasma LC/MS/MS Dydrogesterone 50 pg/ml Plasma GC/MS Enalapril & Enalaprilat 250 pg/ml Plasma LC/MS/MS Eprosartan 1 ng/ml Plasma LC/MS/MS Ergotamine 25 pg/ml Plasma LC/MS/MS Estradiol / Estrone 5 / 5 pg/ml Plasma/Serum GC/MS Estradiol / Estrone 2.5 / 5 pg/ml Plasma/Serum GC/MS Estradiol / Estrone 1 / 2 pg/ml Serum GC/MS Estradiol / Estrone 50 / 100 pg/ml Rat Plasma/Serum GC/MS Estriol 10.0 pg/ml Plasma/Serum GC/MS Free Estrone / Equilin / Estradiol / Delta-8,9-Dehydroestrone 5/5/2.5/2.5 pg/ml Plasma GC/MS Total Estrone / Equilin / Estradiol / Delta-8,9-Dehydroestrone 50/50/10/10 pg/ml Plasma GC/MS Estrone Sulfate 50 pg/ml Plasma LC/MS/MS Estrone Sulfate 50 pg/ml Plasma GC/MS EthinylEstradiol 1 pg/ml Plasma GC/MS Ethinylestradiol 2.5 pg/ml Plasma GC/MS Ethinylestradiol / Norethindrone 2.5 / 25 pg/ml Plasma GC/MS Ethinylestradiol / Norgestrel (levonorgestrel) 10 / 50 pg/ml Serum GC/MS Etoposide 0.5 ng/ml Plasma LC/MS/MS Exemestane 50 pg/ml Plasma LC/MS/MS Famotidine 2 ng/ml Plasma LC/MS/MS Felodipine 50 pg/ml Plasma GC/MS Felodipine 25 ng/ml Plasma LC/MS/MS Fenofibric Acid 10 ng/ml Plasma LC/MS/MS Fentanyl 25 pg/ml Plasma LC/MS/MS

LABORATORY SERVICES Bioanalytical Methods Finasteride 0.5 ng/ml Plasma LC/MS/MS Flavoxate / MFCA metabolite 0.1/50 ng/ml Plasma LC/MS/MS/HPLC UV Fludrocortisone 25 pg/ml Plasma GC/MS Flunisolide 50 pg/ml Plasma GC/MS Fluspirilene 25 pg/ml Plasma GC/MS Flutamide / Hydroxyflutamide 20/2 pg/ml Plasma GC/MS Fluticasone/Salmeterol 2.5 pg/ml Plasma LC/MS/MS Fluvoxamine 200 pg/ml Plasma LC/MS/MS Fosinoprilat 5 ng/ml Plasma LC/MS/MS Furnidipine 25 pg/ml Plasma GC/MS Furosemide 50 ng/ml Plasma LC/MS/MS Gabapentin 50 ng/ml Plasma LC/MS Gadolinium 1 μg/ml Serum/Urine ICP/MS Gemfibrozil 200 ng/ml Plasma LC/MS/M Gliclazide 5 ng/ml Plasma LC/MS/MS Glimepiride 1 ng/ml Serum LC/MS/MS Glycopyronium 1.0 pg/ml Plasma LC/MS/MS Goserelin 0.2 ng/ml Plasma LC/MS/MS Guaifenesin 2.5 ng/ml Plasma LC/MS/MS Haloperidol 25 pg/ml Plasma LC/MS/MS Homocysteine 5 μg/ml Plasma LC/MS/MS Hydrocodone 0.25 ng/ml Plasma LC/MS/MS Hydromorphone 20.0 pg/ml Plasma LC/MS/MS Hydroxymephenytoin, (R)--4-/ Hydroxymephenytoin, (S)-4-10 ng/ml Plasma/Saliva LC/MS/MS Hydroxymephenytoin, (R)--4-/ Hydroxymephenytoin, (S)-4-0.1 μg/ml Urine LC/MS/MS Hydroxymidazolam, a / Hydroxymidazolam, 4-2 / 2 ng/ml Plasma LC/MS/MS 2-Hydroxypropyl-beta-cyclodextrin 0.1 μg/ml Plasma LC/MS Hyoscyamine 50 pg/ml Plasma GC/MS Ibuprofen 0.25 μg/ml Plasma LC/MS/MS Ibuprofen R- / S- 0.25 μg/ml Plasma LC/MS/MS Iloprost 10 pg/ml Plasma LC/MS/MS Imipramine / Desipramine 0.10 ng/ml Plasma LC/MS/MS Indapamide 0.5 ng/ml Plasma LC/MS/MS Indomethacin 20 ng/ml Plasma LC/MS/MS Interferon alpha 10 pg/ml Serum ELISA Iodine 0.5/5 μg/ml Whole Blood/Urine ICP/MS Irbesartan 5 ng/ml Plasma LC/MS/MS Isosorbide Dinitrate 0.1 ng/ml Plasma GC/MS Isosorbide-2-mononitrate 0.25 ng/ml Plasma GC/MS Isosorbide-5-mononitrate 0.25 ng/ml Plasma GC/MS Isotretinoin / 4-Oxo-Isotretinoin 10 ng/ml Plasma LC/MS/MS Isradapine 100 pg/ml Plasma LC/MS/MS Ketoprofen 1 ng/ml Plasma LC/MS/MS Ketoprofen 50 ng/ml Urine GC/MS Ketotifen 25 pg/ml Plasma GC/MS Lacidipine 20 pg/ml Plasma LC/MS/MS Lamotrigine 10 ng/ml Plasma LC/MS/MS Lercanidipine R- & S- 20 pg/ml Plasma LC/MS/MS Letrozole 10 ng/ml Plasma LC/MS/MS Leuprolide 0.04 ng/ml Plasma EIA Levofloxacin 0.2 μg/ml Plasma LC/MS/MS Levonorgestrel 10 pg/ml Plasma/Serum GC/MS This is not a complete list. Where higher levels are measured, only the lowest measure is shown.

One of the largest inventories of validated bioanalytical assays. Lisinopril 1 ng/ml Plasma LC/MS/MS Lisuride 10 pg/ml Plasma LC/MS/MS Lithium 25 ng/ml Serum ICP/MS Loperamide 125 pg/ml Plasma GC/MS Loratadine / Descarboethoxyloratadine 100/50 pg/ml Plasma GC/MS Lorazepam 1.0 ng/ml Plasma LC/MS/MS Lynestrenol 0.1 ng/ml Plasma GC/MS Medrogestone 50 pg/ml Plasma GC/MS Medroxyprogesterone Acetate 0.1 ng/ml Plasma/Serum GC/MS Megesterol Acetate 100 pg/ml Plasma GC/MS Melatonin 5 pg/ml Plasma LC/MS/MS Meloxicam 10 ng/ml Plasma LC/MS/MS Melperone 0.25 ng/ml Plasma GC/MS Memantine 100 pg/ml Plasma GC/MS Mephenytoin (R,S) Phenotyping Urine GC/MS R-Mephenytoin / S-Mephenytoin 10 ng/ml Plasma/Saliva LC/MS/MS R-4-Hydroxymephenytoin / S-4-Hydroxymephenytoin 10 ng/ml Plasma/Saliva LC/MS/MS R-4-Hydroxymephenytoin / S-4-Hydroxymephenytoin 0.1 μg/ml Urine LC/MS/MS R-Mephenytoin / S-Mephenytoin 0.1 μg/ml Urine LC/MS/MS Metformin 10 ng/ml Plasma LC/MS/MS Methamphetamine 100 pg/ml Plasma/Serum GC/MS Methoxyestradiol/Methoxyestrone 5 pg/ml Plasma GC/MS Methylnicotinamide 10 ng/ml Plasma LC/MS/MS Methylphenidate 100 pg/ml Plasma LC/MS/MS Methylprednisolone 0.5 ng/ml Plasma LC/MS/MS Methyltestosterone 50 pg/ml Plasma GC/MS Metoprolol 1.00 ng/ml Plasma LC/MS/MS Midazolam 0.5 ng/ml Plasma GC/MS-LC/MS Minocycline 0.27 ng/ml Plasma LC/MS/MS Mirtazapine 0.5 ng/ml Plasma GC/MS Misoprostol Acid 10 pg/ml Serum LC/MS/MS Moexipril 1 ng/ml Plasma LC/MS/MS Molindone 250 pg/ml Plasma LC/MS/MS Morphine / Morphine-3-glucuronide / Morpine-6-glucuronide 0.5/5/2 ng/ml Plasma LC/MS/MS Moxonidine 0.05/1 ng/ml Plasma/Urine GC/MS Mycophenolic Acid / Mycophenolic Acid Glucuronide 0.1/0.5 ug/ml Dog Plasma LC/MS/MS Niacin (Nicotinic Acid) / Nicotinuric acid 25 ng/ml Plasma LC/MS/MS Nicardipine 25 pg/ml Plasma GC/MS Nicorandil 1 ng/ml Plasma GC/MS Nicotinamide 10 ng/ml Plasma LC/MS/MS Nicotine / Cotinine 0.5/2.5 ng/ml Plasma GC/MS Nilvadipine 50 pg/ml Plasma GC/MS R-Nirvanol / S-Nirvanol 20 ng/ml Plasma/Saliva LC/MS/MS R-Nirvanol / S-Nirvanol 0.25 μg/ml Urine LC/MS/MS Nitisonon 1 ng/ml Plasma LC/MS/MS Nitrendipine 50 pg/ml Plasma GC/MS Nitroglycerin / 1,2 GDN / 1,3 GDN 5/20/10 pg/ml Plasma GC/MS Norethindrone 25 pg/ml Plasma GC/MS Norgestimate / 17-Desacetylnorgestimate 100 pg/ml Plasma LC/MS/MS Norgestrel 0.1 ng/ml Plasma GC/MS Octreotide 25 pg/ml Plasma LC/MS/MS Ondansetron 0.5 ng/ml Plasma LC/MS/MS

LABORATORY SERVICES Bioanalytical Methods & Equipment Oxandrolone 0.25 ng/ml Plasma LC/MS/MS Oxeladin 1 ng/ml Plasma GC/MS Oxybutynin / N-Desethyloxybutynin 0.1/0.25 ng/ml Plasma/Serum LC/MS Oxycodone and Noroxycodcone 0.25 ng/ml Plasma LC/MS/MS Pantoprazole 10 ng/ml Plasma LC/MS/MS Paroxetine 100 pg/ml Plasma LC/MS/MS Pentaerythrityl Mononitrate & Dinitrate 50 pg/ml Plasma GC/MS Pentoxyverine 1 ng/ml Plasma GC/MS Permetrexed 10 ng/ml Plasma LC/MS/MS PGF2 (9-alpha, 11-beta PGF2) 25 pg/ml Plasma LC/MS/MS Platinum 2.5 ng/ml Plasma ICP/MS Potassium 1 mm Urine Ion Selective Electrode Pravastatin 0.5 ng/ml Plasma LC/MS/MS Primidone 25 ng/ml Plasma LC/MS/MS Progesterone 100 pg/ml Plasma LC/MS/MS Promethazine 200 pg/ml Plasma LC/MS/MS Propafenone and N-despropyl- & 5-Hydroxypropafenone 250 pg/ml Plasma LC/MS/MS Propoxyphene / Acetaminophen 1 / 50 ng/ml Plasma LC/MS/MS Propoxyphene / Norpropoxyphene 1 ng/ml Plasma LC/MS/MS PSA 360 pg/ml Serum EIA Pseudoephedrine/Ibuprofen 2/200 ng/ml Plasma LC/MS/MS Quercetin 0.25 μg/ml Plasma LC/MS/MS Repaglinide 200 pg/ml Serum LC/MS/MS Ribavirin 25 ng/ml Plasma LC/MS/MS Risedronic Acid 0.1 / 0.2 ng/ml Plasma / Urine LC/MS/MS Risperidone 0.1 ng/ml Plasma LC/MS/MS Rivastigmine 0.1 ng/ml Plasma LC/MS/MS Ropinirole 20 pg/ml Plasma LC/MS/MS Rosuvastatin 0.25 ng/ml Plasma LC/MS/MS Scopolamine Free 25 pg/ml Plasma GC/MS Scopolamine Free 100 pg/ml Urine GC/MS Selegiline 50 pg/ml Plasma/Serum GC/MS Desmethylselegiline / Methamphetamine / Amphetamine 100 pg/ml Plasma/Serum GC/MS Sertraline 250 pg/ml Plasma GC/MS SHBG 10 nmol/l Plasma/Serum ELISA Simvastatin / Simvastatin Hydroxyacid 0.5/0.5 ng/ml Plasma LC/MS/MS Sitagliptin 100 pg/ml Plasma LC/MS/MS Sirolimus 1 Ng/ml Blood LC/MS/MS Sparteine / 2-DHSP / 5-DHSP 0.5 nmol/l Urine GC/MS Spironolactone 2 ng/ml Plasma LC/MS/MS Strontium 100 ng/ml Plasma ICP/MS Sumatriptan 0.5 ng/ml Plasma LC/MS/MS T3/T4 0.3/10 ng/ml Serum LC/MS/MS Tacrolimus 0.5 ng/ml Blood LC/MS/MS Temazepam 25 ng/ml Plasma LC/MS/MS Terbinafine / N-desmethylterbinafine 40 Pg/ml Plasma LC/MS/MS Terfenadine 0.1 ng/ml Plasma GC/MS Testosterone / 5-α-Dihydrotestosterone 50 pg/ml Plasma GC/MS Testosterone 100 pg/ml Plasma LC/MS/MS Tizanidine 100 pg/ml Plasma LC/MS/MS Tolperisone 500 pg/ml Plasma LC/MS/MS Tolterodine / 5-hydroxymethyl tolterodine 100 pg/ml Plasma LC/MS/MS Topiramate 10 ng/ml Plasma LC/MS/MS This is not a complete list. Where higher levels are measured, only the lowest measure is shown.

With more than 60 qualified scientists at the centre in Neu-Ulm. Tramadol/Acetaminophen 5/100 ng/nl Plasma LC/MS/MS Tranexamic Acid 50 ng/ml Plasma GC/MS Trazodone 10 ng/ml Plasma LC/MS/MS Triamterene 2 ng/ml Plasma LC/MS/MS Triazolam 50 pg/ml Plasma GC/MS Trospium 20 pg/ml Plasma LC/MS/MS Venlafaxine / O-desmethylvenlafaxine 2.5 ng/ml Plasma LC/MS/MS Vinorelbine 1 ng/ml Blood LC/MS/MS Voriconazole 25 ng/ml Plasma (Dog) LC/MS/MS Zolpidem 1 ng/ml Plasma LC/MS/MS BIOANALYTICAL EQUIPMENT LC-MS-MS GC-MS ICP-MS Mass Spectromentry 2 PE Sciex API 6500/UPLC 2 Thermo Scientific DSQ II 1 Perkin Elmer Elan DRC II Mass Spectromentry 6 PE Sciex API 5500/UPLC Mass Spectromentry 2 PE Sciex API 5000 Mass Spectromentry 7 PE Sciex API 4000 Mass Spectromentry 1 PE Sciex API 3000 BIOANALYTICAL EQUIPMENT Clinical Laboratory Roche Cobas 6000 Clinical Laboratory Roche Integra 400 plus Clinical Laboratory Sysmex XT 2000i Clinical Laboratory Roche Cobas t 411 Clinical Laboratory Roche Cobas u 411 BIOANALYTICAL EQUIPMENT Immunoassay Immunoassay Immunoassay Immunoassay Immunoassay Immunoassay FACS Calibur and Canto II Flow Cytometers Tecan M200 Pro ELISA Readers Meso Scale Discovery QuickPlex SQ 120 Systems Singulex Erenna SMC (Single Molecule Counting) withultra High Sensitivity Reader Molecular biology equipment e.g. PCR, Gel Electrophoresis Fully equipped tissue culture lab incl. three sterile work benches, two CO2-incubators, liquid nitrogen specimen storage tank FOR REDEVELOPMENT / REVALIDATION BY LC-MS/MS Acebutalol / Diacetolol 5 ng/ml Plasma HPLC/UV Acetaminophen 0.1 μg/ml Plasma/Urine HPLC/UV N-Acetylcysteine 100 ng/ml Plasma HPLC/UV Acetylsalicylic acid/salicylic acid 25/50 ng/ml Plasma HPLC/UV Acyclovir 20 ng/ml Plasma HPLC/FL Acyclovir 1 μg/ml Urine HPLC/FL Alfuzosin 250 pg/ml Plasma HPLC/Fl Ambroxol 1 ng/ml Plasma HPLC/UV Amiloride 1 ng/ml Plasma HPLC/FL Aminoguanidine 50 ng/ml Plasma HPLC/EC 5-Aminosalicylic acid 2 μg/ml Urine HPLC/FL 5-Aminosalicylic acid 1 ng on col Feces HPLC/FL

LABORATORY SERVICES For Redevelopment & Revalidation by LC-MS/MS Amitriptyline / Nortriptyline/ Amitriptylline-N-oxide 0.5/0.5/50 ng/ml Plasma HPLC/UV Amoxicillin 0.25 μg/ml Plasma HPLC/UV Ampicillin 0.25 μg/ml Plasma HPLC/UV Anipamil 5 ng/ml Plasma HPLC/FL Antipyrine 0.025 μg/ml Plasma HPLC/UV Antipyrine & metabolites 2.5 μg/ml Urine HPLC/UV Astemizole / Desmethylastemizole 250/150 pg/ml Plasma HPLC/EC Atenolol R- / S- 20 ng/ml Plasma HPLC/FL Benserazide 10 ng/ml Plasma HPLC/EC Betaxolol 2 ng/ml Plasma HPLC/Fl Bisoprolol / Bisoprolol Fumerate 2/1 ng/ml Plasma HPLC/FL Bromazepam 1 ng/ml Plasma HPLC/UV Bromhexine / Ambroxol 1 ng/ml Plasma HPLC/UV Bupropion 2.5 ng/ml Plasma HPLC/UV Butalbital 0.1 μg/ml Plasma HPLC/UV Caffeine 0.05 μg/ml Plasma HPLC/UV Captopril 25 ng/ml Plasma HPLC/EC Carabastine 5 ng/ml Plasma HPLC/UV Carbamazepine 0.05 μg/ml Plasma HPLC/UV Carbidopa / Levodopa / 3-O-Methyldopa 2.5/25/25 ng/ml Plasma HPLC/EC RR- & SS-Carboxyibuprofen 2.5 μg/ml Urine HPLC/FL Carboxyibuprofen 5 μg/ml Urine HPLC/FL Cefaclor 0.5 μg/ml Plasma HPLC/UV Cefadroxil 0.25 μg/ml Plasma HPLC/UV Cefdinir 25 ng/ml Plasma HPLC/UV Cefixime 50 ng/ml Plasma HPLC/UV Cefprozil 0.25 μg/ml Plasma HPLC/UV Cephalexin 0.25 μg/ml Plasma HPLC/UV Chinin 10 ng/ml Plasma HPLC/UV Chlormezanone 5 ng/ml Plasma HPLC/UV Chlorpropamide 1 μg/ml Rat Plasma HPLC/UV Chlorthalidone 10 ng/ml Whole Blood HPLC/UV Chlorthalidone 0.2 μg/ml Urine HPLC/UV Cimetidine 50 ng/ml Plasma HPLC/UV Cimetidine 25 μg/ml Urine HPLC/UV Cinnarizine 2 ng/ml Plasma HPLC/UV Ciprofloxacin 25 ng/ml Plasma HPLC/FL Ciprofloxacin 2.0 μg/ml Urine HPLC/FL Cisapride 5 ng/ml Plasma HPLC/FL Clavulanic Acid 10 ng/ml Plasma HPLC/UV Clobutinol 1 ng/ml Plasma HPLC/UV Cortisone 5 ng/ml Plasma HPLC/UV Danazole 1 ng/ml Serum HPLC/UV Dazopride 10 ng/ml Plasma HPLC/EC Demeclocycline 100 ng/ml Plasma HPLC/UV Dextromethorphan / 3-hydroxymorphinan / 4-methoxymorphina 10 ng/ml Plasma HPLC/FL Dextromethorphan / 3-hydroxymorphinan / 4-methoxymorphina 0.25 μg/ml Urine HPLC/FL Dextrorphan 10/250 ng/ml Plasma/Urine HPLC/FL Diazepam / Desmethyldiazepam 2 ng/ml Plasma HPLC/UV Diclofenac 10 ng/ml Plasma HPLC/UV Dihydralazine 1 ng/ml Plasma HPLC/UV Dilazep 2.5 ng/ml Whole Blood HPLC

Frequent inspections by clients and excellent regulatory standing. Dipyridamole 10 ng/ml Plasma HPLC/FL Disopyramide / N-Desmethyldisopyramide 0.1/0.05 μg/ml Plasma HPLC/UV Domperidone 1.0 ng/ml Plasma HPLC/UV Dothiepin 2 ng/ml Plasma HPLC/UV Dothiepin-S-Oxide 5 ng/ml Plasma HPLC/UV Doxazosin 0.2 ng/ml Plasma HPLC/FL Doxepine / Desmethyldoxepine 0.5 ng/ml Plasma HPLC/UV Doxycycline 50 ng/ml Plasma HPLC/UV Doxylamine 5/100 ng/ml Plasma/Urine HPLC/UV Ebastine 10 ng/ml Plasma HPLC/UV Erythromycin A 0.1 μg/ml Plasma HPLC/EC Etilefrine 10 ng/ml Plasma HPLC/UV Etintidine 100 ng/ml Plasma HPLC/UV Etintidine 10 μg/ml Urine HPLC/UV Etodolac 0.1 μg/ml Plasma HPLC/UV Femoxitine / N-Desmethylfemoxitine 5 ng/ml Plasma HPLC/FL Fenbufen 0.1 μg/ml Plasma HPLC/UV Flavoxate / MFCA metabolite 0.1/50 ng/ml Plasma LC/MS/MS/HPLC UV Fluconazole 50 ng/ml Plasma HPLC/UV Flunitrazepam 0.5 ng/ml Serum HPLC/UV Fluoxetine / Norfluoxetine 1 ng/ml Plasma HPLC/UV Flurazepam / N-Hydroxyethyl & N-Desalkyl metabolites 0.75 ng/ml Serum HPLC/UV Flurbiprofen 0.1 μg/ml Plasma HPLC/UV Flurbiprofen R- / S- 0.5 μg/ml Urine HPLC/FL Flurbiprofen R- / S- 0.25 μg/ml Plasma HPLC/FL Furosemide 10 ng/ml Plasma HPLC/FL Gallopamil 2 ng/ml Plasma HPLC/FL Gemcitabine 40 ng/ml Plasma/Urine HPLC/UV Gemfibrozil 0.5 μg/ml Plasma HPLC/UV Glipizide 10 ng/ml Plasma HPLC/UV Glisoxepide 2.5 ng/ml Serum HPLC/UV Glyburide 5 ng/ml Plasma HPLC/UV Granisetron 100 pg/ml Plasma HPLC/Fl Homogentisic Acid 0.25 μg/ml Plasma HPLC/UV Hydralazine Free & Apparent 2.5/0.5 ng/ml Plasma/Whole Blood HPLC/FL Hydrochlorothiazide 1 ng/ml Plasma HPLC/UV Hydrochlorothiazide 0.05 μg/ml Urine HPLC/UV Hydrocortisone 5 ng/ml Plasma HPLC/UV 6 β Hydroxycortisol 0.1 μg/ml Urine HPLC/UV R- & S-Hydroxyibuprofen 2.5 μg/ml Urine HPLC/FL Hypoxanthine 0.25/0.5 μg/ml Plasma/Urine HPLC/UV Indocyanine Green (ICG) 0.3 μg/ml Plasma HPLC/UV Iodide 0.1 μg/ml Plasma HPLC/UV Isoniazide 0.1 μg/ml Plasma HPLC/UV Ketoconazole 50 ng/ml Plasma HPLC/FL Ketoprofen 5/1000 ng/ml Plasma/Urine HPLC/UV Labetalol 1 ng/ml Plasma HPLC/FL Levetiracetam 0.5 μg/ml Plasma HPLC/UV Levomepromazine 1 ng/ml Plasma HPLC/UV Lornoxicam 25 ng/ml Plasma HPLC/UV Losartan / Losartan Carboxy Acid 10/5 ng/ml Plasma HPLC/Fl Medroxyprogesterone Acetate 4 ng/ml Serum HPLC/UV

LABORATORY SERVICES For Redevelopment & Revalidation by LC-MS/MS 6-Mercaptopurine 5 ng/ml Plasma HPLC/UV Metamizol 0.3 μg/ml Plasma HPLC/UV Methimazole 10 ng/ml Plasma HPLC/EC Methocarbamol 0.1 μg/ml Plasma HPLC/FL 6-Methoxy-2-Naphthaleneacetic Acid 0.1 μg/ml Plasma HPLC/FL 5-Methyltetrahydrofolic Acid 10 ng/ml Plasma HPLC/UV Methylsalicylate 80 ng/ml Plasma HPLC/FL Metoclopramide 1 ng/ml Plasma HPLC/UV Metoclopramide 60 ng/ml Urine HPLC/FL Metolazone 2 ng/ml Plasma HPLC/Fl Metoprolol/Hydroxymetoprolol 2.5/1000 ng/ml Plasma/Urine HPLC/FL Mexiletine 10 ng/ml Plasma HPLC/UV Mianserin 1 ng/ml Plasma HPLC/UV Minocycline 25 ng/ml Plasma HPLC/UV Mivazerol 0.1/10 ng/ml Plasma/Urine HPLC/FL Naftidrofuryl 5 ng/ml Plasma HPLC/FL Naloxone 1 ng/ml Plasma HPLC/EC Naltrexone / 6-b-Naltrexol 0.1/0.5 ng/ml Plasma HPLC/FL Naproxen 0.5 μg/ml Plasma HPLC/FL Nefazodone 10 ng/ml Plasma HPLC/UV Nicardipine 0.5 ng/ml Plasma HPLC/EC Nicergoline + M1 and M2 Metabolites 0.5 ng/ml Plasma HPLC/UV Nicorandil 50 ng/ml Urine HPLC/UV Nifedipine / NPO 1 ng/ml Plasma HPLC/UV Nimesulide / Hydroxynimesulide 20 ng/ml Plasma HPLC/UV Nitrofurantoin 5 ng/ml Plasma HPLC/UV Nitrofurantoin 2 μg/ml Urine HPLC/UV Northiaden / Northiaden-S-Oxide 2/5 ng/ml Plasma HPLC/UV Orphenadrine 1 ng/ml Plasma HPLC/UV Oxaprozin 2 μg/ml Plasma HPLC/UV Oxazepam 10 ng/ml Plasma HPLC/UV Oxazepam 0.1 μg/ml Urine HPLC/UV Oxprenolol 2.5 ng/ml Plasma HPLC/UV Papaverine, Phentolamine 1 ng/ml Plasma HPLC/UV Paraxanthine 25 ng/ml Plasma/Serum HPLC/UV Pelargonidin 10/40 ng/ml Plasma/Urine HPLC/UV Pentoxifylline 4 ng/ml Plasma HPLC/UV Phenoxymethylpenicillin (Penicillin V) 0.1 μg/ml Plasma HPLC/UV Phenylpropanolamine 2 ng/ml Plasma HPLC/FL Phenylpropanolamine 5 μg/ml Urine HPLC/FL Phenylpropanolamine D- / L- 8.1 ng/ml Plasma (Human/Dog) HPLC/UV Phenylpropanolamine D- / L- 2.4 ng/ml Urine (Dog) HPLC/UV Phenytoin 0.25 μg/ml Plasma HPLC/UV Free Phenytoin / Phenylhhydantoin / Phenobarbitol 0.1 μg/ml Urine HPLC/UV Phenytoin 1 μg/ml Urine HPLC/UV Pindolol 1 ng/ml Plasma HPLC/UV Piracetam 0.5 μg/ml Plasma HPLC/UV Piroxicam 50 ng/ml Plasma HPLC/UV Prazosin 0.1 ng/ml Plasma HPLC/FL Prednisolone 1 ng/ml Plasma HPLC/UV Prednisone 1 ng/ml Plasma HPLC/UV Prednyliden 5 ng/ml Plasma HPLC/UV

Over 35 years of experience in Bioanalytics. Probucol 0.25 μg/ml Plasma HPLC/UV Procainamide / Acetylprocainamide 0.2 μg/ml Plasma HPLC/UV Propofol 2.5 ng/ml Plasma HPLC/FL Propranolol / 4-Hydroxypropranolol 2.5 ng/ml Plasma HPLC/FL Propranolol Glucuronide 1 μg/ml Urine HPLC/FL Pseudoephedrine 0.5 μg/ml Urine HPLC/UV Quinidine 10 ng/ml Plasma HPLC/UV Quinine 10 ng/ml Plasma HPLC/UV Quinolone 50/100 ng/ml Plasma/Urine HPLC/UV Ranitidine 5 ng/ml Plasma HPLC/UV Reserpine 25 pg/ml Plasma HPLC/FL Rifampicin / Desacetylrifampin 0.1 μg/ml Plasma HPLC/UV Rosoxacin 0.1 μg/ml Plasma/Oviduct/Uterus HPLC/UV Salicylic Acid 0.25 μg/ml Plasma HPLC/UV Salicylic Acid 0.7/9.2 μg/ml Plasma/Urine HPLC/FL Salicyluric Acid 25 ng/ml Plasma HPLC/UV Salicyluric Acid 2.5 μg/ml Urine HPLC/UV Sildenafil / N-desmethylsildenafil 1/1 ng/ml Plasma HPLC/UV Sotalol 50 ng/ml Plasma HPLC/FL Sulfamethoxazole 250 ng/ml Plasma HPLC/UV Sulfamethoxazole 1 μg/ml Urine HPLC/UV Sulindac / Sulindacsulfone / Sulindacsulfide 0.25 μg/ml Plasma HPLC/UV Sulpiride 10 ng/ml Plasma HPLC/FL Tamoxifen / N-Desmethyltamoxifen 0.5/0.25 ng/ml Plasma HPLC/FL Telmisartan 500 pg/ml Plasma HPLC/Fl Tenoxicam 20 ng/ml Plasma HPLC/UV Terbutaline 0.25 ng/ml Plasma HPLC/EC Terconazole 0.5 ng/ml Plasma HPLC/EC Terfenadine Metabolite M1 25 ng/ml Plasma HPLC/FL Terfenadine Metabolite M1/M2 250 ng/ml Urine HPLC/FL Tetrazepam 2 ng/ml Plasma HPLC/UV Theophylline 50 ng/ml Plasma HPLC/UV Theophylline 0.2 μg/ml Serum/Plasma HPLC/UV Thiothixene 0.5 ng/ml Serum HPLC/UV Tiaprofenic Acid 100 ng/ml Plasma HPLC/UV Ticlopidine 5 ng/ml Plasma HPLC/UV Timolol 2 ng/ml Plasma HPLC/UV Tolbutamide / Carboxytolbutamide / Hydroxytolbutamide 0.25/0.5/0.5 μg/ml Plasma HPLC/UV Tramadol 2.5 ng/ml Plasma HPLC/UV Triamterene / Hydroxytriamterene Sulfate 5/25 ng/ml Plasma HPLC/FL Triamterene / Hydroxytriamterene Sulfate 0.125/1.25 ng/ml Urine HPLC/FL Trimethoprim/Sulfamethoxazole 10/250 ng/ml Plasma HPLC/UV Trimethoprim 1 μg/ml Urine HPLC/UV Trimipramine / N-desmethyltrimipramine 2 / 2 ng/ml Plasma HPLC/UV Valsartan 50 ng/ml Plasma HPLC/Fl Verapamil / Norverapamil 2.5 ng/ml Plasma HPLC/FL Veratric Acid 50 ng/ml Plasma HPLC/UV Vitamin E 0.5 μg/ml Plasma HPLC/UV Warfarin R- & S- 50 ng/ml Plasma HPLC/FL Xanthine 0.5/1.0 μg/ml Plasma/Urine HPLC/UV Zatebradine 1.5 ng/ml Plasma HPLC/FL Zonisamide 50 ng/ml Serum HPLC/UV

Our resources become yours. Fully integrated Contract Research Organisation with over 35 years of serving the pharmaceutical industry. A leading CRO driven by Experience, Commitment, and Technology made in Germany. GmbH Wegenerstrasse 13 89231 Neu-Ulm[nbsp] Germany Phone: +49 731 9840 0 Fax: +49 731 9840 280 Analytical Services GmbH Im Wirrigen 25 45731 Waltrop Germany Phone: +49 2309 9376 0 Fax: +49 2309 9376 420 Nuvisan Pharma Grafing GmbH Am Feld 32 85567 Grafing Germany Phone: +49 8092 7008 0 Fax: +49 80832 7008 99