International Conference on Neurological Disorders and Neurorestoration

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1 International Conference on Neurological Disorders and Neurorestoration with Academia of the European Brain Council May 2019 Hotel Importanne Neptun, Dubrovnik, Croatia Under the auspices of the President of the Republic of Croatia Kolinda Grabar-Kitarović

2 International Conference on Neurological Disorders and Neurorestoration Poštovane kolegice i kolege, dragi prijatelji, čast nam je i zadovoljstvo pozvati Vas na Međunarodni kongres neuroloških bolesti i neurorestauracije koji će se održati od svibnja godine u hotelu Neptun u Dubrovniku! MEĐUNARODNI KONGRES NEUROLOŠKIH BOLESTI I NEURORESTAURACIJE jedinstven je međunarodni skup koji pokriva sva glavna područja neurologije, neuroznanosti i neurorestauracije: od neuroinflamacije, neurodegeneracije, ishemijskih bolesti, preko epilepsija i ekstrapiramidnih bolesti. Poseban naglasak Kongresa jest na trenutnim dometima u obnovi tkiva i funkcije (neurorestauracija). Jedinstvenost Kongresa se ogleda u tome što, po prvi puta, uz Medicinski fakultet u Zagrebu kao glavnog organizatora, kao su-organizatori nastupaju sve Klinike za neurologiju zagrebačkih kliničkih i bolničkih centara. Također smo ponosni što značajan broj stranih predavača koji dolaze iz najeminentnijih svjetskih centara, iz Europe, SAD i Azije. Dodatnu posebnost Kongresa donosi satelitski simpozij u orga nizaciji European Brain Council, krovne europske institucije u području istraživanja bolesti mozga. Srdačan pozdrav i do skorog viđenja u Dubrovniku! Prof. dr. sc. Ervina Bilić, prim. dr. med. specijalist neurolog Predstojnica Klinike za neurologiju Kliničkog bolničkog centra Zagreb i Medicinskog fakulteta Sveučilišta u Zagrebu Prof. dr. sc. Dinko Mitrečić, dr. med. Voditelj Laboratorija za matične stanice, Sveučilište u Zagrebu Medicinski fakultet Dear colleagues and dear friends, It is our great pleasure and honor to invite you to the International Conference on Neurological Disorders and Neurorestoration which will take place from May 10-13, 2019 in Hotel Neptun, Dubrovnik! International Conference on Neurological Disorders and Neurorestoration is a unique international meeting that covers all major areas of neurology, neuroscience and neurorestation: neuroinflammation, neurodegeneration, ischemic diseases, paroxysmal and extrapyramidal diseases. The special emphasis of the Conference is on the current options of tissue and functional restoration (neurorestoration). The uniqueness of the Conference is reflected as well in the fact that, for the first time, the main organizer, University of Zagreb School of Medicine is supported by all the Clinics for Neurology of the Zagreb Clinical and Hospital Centers. We are also proud that many lectures will be delivered by speakers coming from the most eminent world centers, from Europe, the USA and Asia. An additional specialty of the Conference is the satellite symposium organized by the European Brain Council, European umbrella organization in brain disease research. We look forward to seeing you in Dubrovnik! Prof. Ervina Bilic, MD. PhD. neurologist Head of the Department of Neurology Clinical Hospital Center Zagreb, University of Zagreb School of Medicine Prof. Dinko Mitrecic, MD. PhD. Head of the Laboratory for Stem Cells, University of Zagreb School of Medicine - 2 -

3 10 13 May 2019 Hotel Importanne Neptun, Dubrovnik, Croatia ORGANIZATORI / ORGANIZERS Organizator zajedničkog kongresa / Joint Event Organized by Sveučilište u Zagrebu Medicinski fakultet/university of Zagreb School of Medicine Kongres organiziran u suradnji s / Coorganized by Klinikama za neurologiju (Klinički bolnički centri Zagreb, Sestre Milosrdnice, Rijeka, Osijek i Split; Klinička bolnica Dubrava) / Departments of Neurology (Clinical Hospital Centers Zagreb, Sestre Milosrdnice, Rijeka, Osijek and Split; Clinical Hospital Dubrava) Hrvatsko neurološko društvo / Croatian Neurological Society Hrvatsko društvo za neuromuskularne bolesti i kliničku elektromioneurografiju / Croatian Society for Neuromuscular Diseases and Clinical Electromyoneurography Hrvatsko društvo za EEG i kliničku neurofiziologiju/croatian Society for Electroencephalography and Clinical Neurophysiology ENCALS-Zagreb Kongres podržan od / Endorsed by European Brain Council European Union Joint Programme for Neurodegenerative Disease Research Paul Gillcrist Foundation MJESTO ODRŽAVANJA / CONGRESS VENUE Hotel Neptun Dubrovnik, Hrvatska / Croatia POKROVITELJI / UNDER THE AUSPICES OF Pod visokim pokroviteljstvom Predsjednice Republike Hrvatske Kolinde Grabar-Kitarović / Under the auspices of the President of the Republic of Croatia Kolinda Grabar-Kitarović ORGANIZACIJSKI ODBOR / ORGANIZING COMMITTEE Predsjednik / President: Prof.dr.sc. Ervina Bilić Članovi / Members: Prof.dr.sc. Vanja Bašić Kes, Prof.dr.sc. Silvio Bašić, Prof.dr.sc. Silva Butković Soldo, Prof.dr.sc. Branko Malojčić, Prof.dr.sc. Dinko Mitrečić, Prof.dr.sc. Meri Matijaca, Prof.dr.sc. Zdravka Poljaković, Doc.dr.sc. Vladimira Vuletić ZNANSTVENI ODBOR / SCIENTIFIC COMMITTEE Predsjednik / President: Prof.dr.sc. Dinko Mitrečić Članovi / Members: Prof.dr.sc. Ervina Bilić, Prof.dr.sc. Fran Borovečki, Prof.dr.sc. Srećko Gajović, Prof.dr.sc. Mario Habek, Prof.dr.sc. Željka Petelin Gadže, Prof.dr.sc. Damir Petravić, Prof.dr.sc. Roland Pochet, Prof.dr.sc. Maja Relja ZNANSTVENI PROGRAM / SCIENTIFIC PROGRAM Kongres će se odvijati u obliku usmenih izlaganja, satelitskih simpozija i postera. Službeni jezik Kongresa je engleski jezik. / The Congress will be organized in a form of oral presentations, posters, satellite symposia. The official language of the Congress is English

4 International Conference on Neurological Disorders and Neurorestoration 09 May 2019 EUROPEAN BRAIN COUNCIL SYMPOSIUM European Brain Council and National Brain Councils meeting 10 May Meeting organized by European Brain Council OPENING OF THE CONFERENCE Presidential lectures M. Klarica, University of Zagreb School of Medicine, Dean M. Di Luca, Italy, European Brain Council, president The future of brain research in Europe M. Cudkowicz, Harvard Medical School, Department of Neurology, Head Accelerating ALS-treatment discovery: targets, therapies and platform trials 20:00 Dinner 11 May 2019 NEUROINFLAMMATORY DISEASES I. Munitić, University of Rijeka Immunity in ALS L. Mazzini, University Novara, Italy, ALS center, Head Stem cell therapy for ALS: where we stand and where we go E. Bilić, Clinical Hospital Center Zagreb, Department of Neurology, Head ALS in real life: what have we learned? G. Pavliša, Clinical Hospital Center Zagreb Assessment of the pulmonary function in ALS Break SYMPOSIUM supported by NOVARTIS R. Milo, Barzilai University Medical Center, Ashkelon, Israel, Department of Neurology, Chairman B-lymphoctes based targeting of multiple sclerosis C. Dreyfus, Robert Wood Johnson Medical School, USA, Department of Neuroscience, Head Metabotropic glutamate receptor agonists enhance remyelination in a model of Multiple Sclerosis V. Bašić Kes, Clinical Hospital Center Sestre Milosrdnice, Department of Neurology, Head Progressive multiple sclerosis M. Habek, Clinical Hospital Center Zagreb Interaction between immune and autonomic nervous systems in multiple sclerosis SYMPOSIUM supported by SANOFI SYMPOSIUM supported by MEDIS Lunch - 4 -

5 10 13 May 2019 Hotel Importanne Neptun, Dubrovnik, Croatia NEURODEGENERATIVE DISEASES SYMPOSIUM supported by SANOFI D. Nižetić, Nanyang Technological University Singapore & Imperial College London Understanding Alzheimer s disease modulating mechanisms by studying its commonest genetic form B. Trapp, Cleveland Clinic, Head of Department Pathogenesis of Neurological Disability in Multiple Sclerosis F. Borovečki, Clinical Hospital Center Zagreb Genomics of neurodegenerative diseases V. Vuletić, Clinical Hospital Center Rijeka, Department of Neurology, Head Deep brain stimulation in movement disorders - from bench to bedside Break SYMPOSIUM supported by MERCK SYMPOSIUM supported by ROCHE 1900 Welcome ceremony (Old Dubrovnik Theatre Marin Držić) 12 May 2019 NEURORESTORATION Z. Kokaia, Lund University, Sweden, Stem Cells & Restorative Neurology Center, Head Stem cell-derived cortical neurons for restoration of stroke-lesioned brain D. Chudy, Clinical Hospital Dubrava, Department of Neurosurgery, Head Deep brain stimulation in disorder of consciousness - our experience and review of literature N. Mimica, Clinical Hospital Center Zagreb How can technology help people with(out) dementia M. Zmajević Schonwald, Clinical Hospital Center Sestre Milosrdnice Intraoperative neurophysiology- to what extent does monitoring help during awake brain surgeries and can we prevent postoperative neurological deficits? Break with the POSTER SESSION SYMPOSIUM supported by MEDIS D. Ježek, University of Zagreb School of Medicine Can the testis treat the brain? J. Isaković, Omnion Research International Application of electromagnetic fields for neurorestoration: from theoretical developments to novel therapies D. Mitrečić, University of Zagreb School of Medicine Influence of hypoxia on developing neural precursors lessons for neurorestoration SYMPOSIUM supported by BERLIN-CHEMIE SYMPOSIUM supported by NOVARTIS Lunch - 5 -

6 International Conference on Neurological Disorders and Neurorestoration EPILEPSY S. Bašić, Clinical Hospital Dubrava, Department of Neurology, Head Approaches to refractory epilepsy Ž. Petelin Gadže, Clinical Hospital Center Zagreb Vagal nerve stimulation in drug-resistant epilepsy - from late to early implantation V. Šulentić, Clinical Hospital Center Zagreb Autoimmune limbic encephalitis - do we know enough? SYMPOSIUM supported by PLIVA Break ORAL PRESENTATIONS OF THE SELECTED POSTERS CEREBROVASCULAR DISEASES S. Gajović, Head of Department, University of Zagreb School of Medicine Longitudinal in vivo imaging to evaluate ischemic brain lesion in the mouse M. Roje Bedeković, Clinical Hospital Center Sestre Milosrdnice Immunosenescence and stroke Z. Poljaković, Clinical Hospital Center Zagreb Neuroprotection in cerebrovascular diseases - myth or future? B. Malojčić, Clinical Hospital Center Zagreb Preventing and restoring the consequences of chronic vascular brain disease T. Breitenfeld, Clinical Hospital Center Sestre Milosrdnice Benefits of music therapy for recovery of stroke and other neurological diseases A. Lovrenčić-Huzjan, Clinical Hospital Center Sestre Milosrdnice Is prevention of cerebrovascular disease possible in fibromuscular dysplasia? SYMPOSIUM supported by ORION PHARMA 2030 Congress Dinner 13 May EXTRAPYRAMIDAL DISEASES M. Relja, Clinical Hospital Center Zagreb Dystonia: an underdiagnosed disease? S. Telarović, Clinical Hospital Center Zagreb Genetic of the Wilson s disease - our experiences Z. Trkanjec, Clinical Hospital Center Sestre Milosrdnice Treatment of advanced Parkinson s disease SYMPOSIUM supported by ABBVIE SYMPOSIUM supported by MEDTRONIC - 6 -

7 10 13 May 2019 Hotel Importanne Neptun, Dubrovnik, Croatia PRIJAVA ZA SUDJELOVANJE / REGISTRATION 1. Prije početka Kongresa / Advanced registration - obrazac za prijavu (offline) ili elektronska prijava (online) na kongresnoj internet stranici / offline or online registration via Registration form on the Congress web page: 2. Prijava na Kongresu / On-site registration - prijava će biti moguća na registracijskom mjestu za cijelo vrijeme trajanja Kongresa. - on-site registration will be possible during the Congress. KOTIZACIJE / REGISTRATION FEES Sudionici / Participant 3.500,00 HRK / 470 EUR Sponzorsko osoblje / Company representative (sponsor) 3.000,00 HRK / 400 EUR Osobe u pratnji / Accompanying person 1.900,00 HRK / 255 EUR Kotizacija za sudionike i sponzore uključuje: pristup predavanjima i izložbenom prostoru, kongresne materijale, kavu i osvježenje, program dobrodošlice , kongresnu večeru , bodove prema Pravilniku povjerenstva za trajno usavršavanje Hrvatske liječničke komore. Kotizacija za osobe u pratnji uključuje: program dobrodošlice i kongresnu večeru The fee for the participants and sponsors includes: access to lectures and exhibition space, congress materials, coffee and refreshments, the welcome program on 11 th May, the congress dinner on May 12 th 2019 and points according to the Regulations of the Commission for Continuous Training of the Croatian Medical Chamber. The fee for accompanying persons includes: the welcome program on 11 th May and the congress dinner on May 12 th **U iznose je uključen PDV od 25%. / VAT (25%) is included. HOTELSKI SMJEŠTAJ / HOTEL ACCOMMODATION - obrazac za prijavu (offline) ili elektronska prijava (online) na kongresnoj internet stranici / offline or online registration via Registration form on the Congress web page: Smještaj sudionika je organiziran u hotelu Neptun. / The accommodation is organized in Hotel Neptun HOTEL NEPTUN **** jednokrevetna soba / single room 1.150,00 HRK / 155 EUR dvokrevetna soba / Double room 1.520,00 HRK / 205 EUR Cijena po sobi i noćenju na bazi polupansiona / Price per room based on half board (breakfast + extra meal): uključena večera / dinner included uključen ručak / lunch included uključen ručak / lunch included uključen doručak / breakfast included - 7 -

8 International Conference on Neurological Disorders and Neurorestoration AVIO KARTE / AIR TICKETS - obrazac za prijavu (offline) ili elektronska prijava (online) na kongresnoj internet stranici / offline or online registration via Registration form on the Congress web page: POLASCI iz Zagreba za Dubrovnik / DEPARTURES from Zagreb to Dubrovnik a) Zagreb - Dubrovnik / petak Let OU 668 iz Zagreba u 11:40 / slijetanje u Dubrovnik 12:45 Cijena HRK 700,00 / Zagreb - Dubrovnik / 10 th May 2019 Friday Flight OU 668 from Zagreb at 11:40 / arrival to Dubrovnik 12:45 The price HRK 700,00/Zagreb b) Zagreb - Dubrovnik / petak Let OU 662 iz Zagreba u 14:45 / slijetanje u Dubrovnik 15:40 Cijena HRK 700,00 / Zagreb - Dubrovnik / 10th May 2019 Friday Flight OU 662 from Zagreb at 14:45 / arrival to Dubrovnik 15:40 The price HRK 700,00 POLAZAK iz Dubrovnika za Zagreb / DEPARTURE from Dubrovnik to Zagreb Zagreb - Dubrovnik / ponedjeljak Let OU 665 iz Dubrovnika u 16:20 / slijetanje u Zagreb 17:15 Cijena HRK 650,00 / Dubrovnik - Zagreb / 13 th May 2019 Monday Flight OU 665 from Dubrovnik at 16:20 / arrival to Zagreb 17:15 The price HRK 650,00 TRANSFERI / THE TRANSFERS - obrazac za prijavu (offline) ili elektronska prijava (online) na kongresnoj internet stranici / offline or online registration via Registration form on the Congress web page: ZRAČNA LUKA DUBROVNIK HOTEL NEPTUN/HOTEL NEPTUN ZRAČNA LUKA DUBROVNIK/ The airport Dubrovnik Hotel Neptun / Hotel Neptun the airport Dubrovnik Cijena po smjeru po osobi 145,00 kn / 19 EUR /The price per person / per way HRK 145,00 / 19 EUR UPUTE ZA PISANJE I SLANJE SAŽETAKA / INSTRUCTIONS FOR WRITING AND SUBMITTING ABSTRACTS Sudionici koji žele održati usmeno izlaganje ili prikazati poster moraju poslati sažetak koji će pregledati Znanstveni odbor. Sažeci moraju biti napisani na engleskom jeziku, a biti će tiskani u časopisu Neurologia Croatica. Nakon primitka sažetka, Znanstveni odbor će odlučiti o prihvaćanju ili odbijanju sažetka, te će odabrati četiri najbolja sažetka postera za kratku oralnu prezentaciju Izlaganje radova, usmeno ili u obliku postera, nije moguće bez uplaćene kotizacije (osim radova pozvanih predavača). Participants who would like to present an oral or poster presentation should submit an abstract for consideration by the Scientific Committee. The abstracts should be submitted in English, and will be published in the indexed journal Neurologia Croatica. The Scientific Committee will choose four poster abstracts for a short oral presentation. Oral or poster presentation is not possible if the registration fee is not paid (excluding invited speakers). Upute za slanje sažetaka / Instructions for Submitting Abstracts Sažetak molimo poslati isključivo putem online obrasca na kongresnoj internetskoj stranici: Sažetke poslane putem kongresne internetske stranice će pregledati Znanstveni odbor. Molimo da pratite upute za slanje sažetaka na internetskoj stranici korak po korak. Molimo da ne šaljete više kopija istog sažetka. Dobit ćete potvrdu da je Vaš sažetak zaprimljen. Rok za slanje sažetaka: 15. ožujka Rok za prihvaćanje sažetaka: 1. travnja

9 10 13 May 2019 Hotel Importanne Neptun, Dubrovnik, Croatia Abstracts should be submitted only via the online submission form available on the Congress web site: Abstracts submitted via the conference web site will be sent to the Scientific Committee for review. Please follow the instructions on the web site step-by-step. Please do not submit multiple copies of the same abstract. You will receive confirmation that your abstract has been forwarded for review. Deadline for submitting abstracts: March 15, 2019 Deadline for accepting abstracts: April 1, 2019 METODE IZLAGANJA / METHODS OF PRESENTATION Usmeno izlaganje i Posteri / Oral Presentation i Posters - prezentacije moraju biti na engleskom jeziku - presentations has to be in English language Upute za prezentacije / Instructions for presentations - na kongresu će se koristiti PC računala. Prezentacije trebaju biti pripremljene u Microsoft PowerPoint (PPT) programu. Macintosh korisnici svoju prezentaciju moraju eksportirati u obliku MS PowerPoint datoteke. - predavači se mole da radi provjere ispravnosti medij s predavanjem predaju tehničaru Kongresne agencije najmanje 1 sat prije predviđenog termina za prezentaciju - predavači se mole da bilo kakve posebne naputke vezane uz prezentacije daju tehničkom osoblju unaprijed, ne za vrijeme predavanja Izlaganje radova, usmeno ili u obliku postera, nije moguće bez uplaćene kotizacije (osim radova pozvanih predavača). - computers onsite will be PC s. Presentations should be in Microsoft PowerPoint (PPT), windows-based environment. Macintosh users who want to submit presentations must export their presentation as a MS PowerPoint file - speakers are kindly asked to prepare their presentations at least 1 hour before their lecture and give them to the Congress Agency technician - speakers are kindly asked to give the technical personnel any special instructions they may havein advance, not during the lecture Oral or poster presentation is not possible if the registration fee is not paid (excluding invited speakers). KONGRESNA IZLOŽBA / CONGRESS EXHIBITION Za vrijeme trajanja Kongresa organizirat će se izložba medicinske opreme i proizvoda. Za sve informacije te cijene sudjelovanja na izložbi i oglašavanja u Konačnom programu i Knjizi sažetaka, molimo kontaktirati Kongresnu agenciju. During the Congress, an industrial exhibition of medical manufacturers and pharmaceutical companies will be organised in the congress area. Companies interested in advertising their products in the congress exhibition and in the congress materials, Final Program and Book of Abstracts, should contact the Congress agency

10 International Conference on Neurological Disorders and Neurorestoration OPĆE INFORMACIJE / GENERAL INFORMATION Mjesto održavanja / Congress venue Hotel Neptun, Dubrovnik, Hrvatska / Croatia Službeni jezik / Official language Službeni jezik Kongresa je engleski. Simultano prevođenje neće biti osigurano. Official language is English. Simultaneous translation will not be provided. Vrednovanje i potvrda o sudjelovanju / Certificate of attendance Sudjelovanje na Kongresu bodovat će se sukladno Pravilnicima strukovnih komora (Hrvatska liječnička komora) Potvrde o sudjelovanju će biti izdane svim sudionicima Kongresa. A Certificate of Attendance will be issued to all registered participants (Croatian Medical Chamber). Službene oznake / Official badges Svi registrirani sudionici s plaćenom kotizacijom dobit će službene kongresne oznake (ID kartice) koje su obvezni nositi na svim mjestima stručnog i društvenog programa Kongresa. All registered participants with registration fee paid will get Congress badges and are obligated to wear them during the scientific and social program. INFORMACIJE O TEHNIČKOJ ORGANIZACIJI / TECHNICAL ORGANIZATION INFORMATION Prijave za sudjelovanje, rezervacija smještaja, plaćanje kotizacija i smještaja, informacije za izlagače, oglašivače i sponzore, tehnička organizacija: Registration, accommodation, congress information for participants, exhibitors, advertisers, and sponsors, technical organization: KONGRESNA AGENCIJA / CONGRESS AGENCY BTravel d.o.o. Maksimirska cesta 112a, Zagreb, Hrvatska / Croatia Kontakt osoba / Contact person: Ivana Šabanović - Uzelac M T ivana.sabanovic-uzelac@btravel.pro W