Wspomnienie o profesorze Henryku Lamparczyku

CAMERA SEPARATORIA Volume 5, Number 1 / January 2013, 35-41 Paweł Konrad Zarzycki Zakład Toksykologii i Bioanalityki, Wydział Inżynierii Lądowej, Środowiska i Geodezji, Politechnika Koszalińska, Śniadeckich 2,75-453 Koszalin, e-mail: pkzarz@wp.pl or pawel_k_z@hotmail.com Wspomnienie o profesorze Henryku Lamparczyku W dniu 16 listopada 2012 roku zmarł Profesor Henryk Lamparczyk (1947-2012). Profesor całe swoje życie zawodowe poświęcił badaniom dotyczącym chromatografii, chemii fizycznej i chemometrii. Rezultaty tych badań, opublikowane w ponad 100 pracach naukowych, znalazły zastosowanie praktyczne, głównie w analizie leków, farmakokinetyce, kosmetologii, współczesnej bioanalityce oraz analizie środowiska, jak również żywności. Profesor był wieloletnim pracownikiem Studium Farmaceutycznego CMKP w Bydgoszczy oraz Akademii Medycznej w Gdańsku, sprawując funkcje Kierownika Zakładu Biofarmacji (CMKP) oraz Katedry Chemii Farmaceutycznej (AMG). Swoje pasje naukowe z sukcesem realizował podczas wieloletnich staży, uzyskanych w drodze międzynarodowych konkursów, w wiodących zagranicznych ośrodkach badawczych Anglii, Japonii oraz Hiszpanii. Należał On do pionierów wykorzystania narzędzi chemometrycznych w przetwarzaniu i interpretacji danych pozyskanych poprzez spektroskopię, chromatografię oraz termoanalizę. Obszar badań Profesora był imponujący i dotyczył między innymi: fizykochemii związków krzemoorganicznych, oddziaływań elektrostatycznych, polaryzowalności, indeksów retencji, parametru kształtu, zagadnień QSRR i QSAR, termodynamiki i optymalizacji procesów rozdzielania w chromatografii gazowej, cieczowej oraz elektroforezie kapilarnej, wykorzystania faz ciekłokrystalicznych do rozdzielania przy pomocy GC, chemii supramolekularnej - w szczególności kompleksów typu gość-gospodarz z wykorzystaniem cyklodekstryn i antybiotyków makrocyklicznych, specjacji węglowodorów i antybiotyków w próbkach żywności oraz kosmetykach, analizy n-alkanów oraz WWA w materiałach pobranych z ekosystemów wodnych, oznaczania kwasu nikotynowego, kumaryn oraz sterydów w materiałach biologicznych, profilowaniem poziomu estrogenów w cyklu miesięcznym oraz w trakcie ciąży, problemów związanych z rozdzielaniem izomerów związków organicznych (w tym enancjomerów), metabolizmu substancji rakotwórczych, składu enancjomerycznego olejków eterycznych oraz wosków, biodostępności leków z preparatów farmaceutycznych, a ostatnio wpływu płci na farmakokinetykę wybranych leków. Wiele prac Jego autorstwa włączając w to artykuł pt. The role of electric interactions in the retention index concept. Universal interaction indices for GLC, HPLC and TLC (Chromatographia 20, 1985, 283-288; pełną listę publikacji Profesora zamieszczam poniżej) jest powszechnie uznawanych za kamienie milowe współczesnej nauki o rozdzielaniu. Był osobą otwartą na każdą dyskusję dotyczącą nauki, historii, architektury oraz muzyki, niezmiernie hojną i bezinteresowną w dzieleniu się swoją wiedzą, przemyśleniami i pomysłami naukowymi. Profesor wypromował 9 doktorów. Z perspektywy ponad 20-letniej pracy z Profesorem mogę stwierdzić, że nigdy i nigdzie nie zabiegał o popularność. Był człowiekiem prostolinijnym, bezkompromisowym i klarownym w swoich ocenach oraz poglądach, umiejącym docenić zaangażowanie w pracy wszystkich swoich wspópracowników. In memory of professor Henryk Lamparczyk Professor Henryk Lamparczyk prematurely passed away on November 16, 2012, at age of 65 years. Professor made a massive contribution to chromatography, physical chemistry and chemometrics. His passion for science performed successfully out of the Poland during long-term research visits as the international competitive grants winner in Great Britain, Japan and Spain. Since 1974 Professor Henryk Lamparczyk has published over 100 scientific papers mainly related to environmental analysis, structureretention and structure-activity relationships, chromatography, drug analysis as well as pharmacokinetics. One of his first research interest was study on intermolecular interactions involved in supramolecular chemistry and separation science, particularly chromatography and electrophoresis. He clearly demonstrated that general behavior of the solute molecules in chromatographic systems can be explained on the basis of solute-phases reversible interactions like electrostatic (van der Waals) forces and stereoselective molecular fitting to stationary and mobile phases. In this field he has studied the effect of electrostatic interactions on chromatographic retention using number of analytes, including polycyclic aromatic hydrocarbons,

36 P.K. Zarzycki polychlorinated biphenyls and steroids. He successfully proposed an electrostatic retention index system common to GC, HPLC and TLC based on the experimental data involving silica, octadecyl-silica, arenyl-silica as well as liquid crystalline stationary phases. His work entitled The role of electric interactions in the retention index concept. Universal interaction indices for GLC, HPLC and TLC (Chromatographia 20, 1985, 283-288; full publication list is enclosed below) is commonly recognized as the separation science milestone. Using simple molecular descriptors including molecule shape, polarizability, dipole moment, and ionization potential values of the solutes and mobile phase components, he and co-workers were successful to explain the retention properties of target analytes in complex chromatographic systems. In spite of his latest research, which was mainly focused on drug analysis and pharmacokinetic studies, he productively used and reported a planar chromatography technique as the key tool for preliminary study concerning separation and detection capability of complex mixtures, also using multivariate statistics approach including principal components analysis. He has published number of research papers concerning supramolecular chemistry, mainly based on temperature effects on host-guest interactions between cyclodextrins and steroids. Professor Henryk Lamparczyk successfully supervised nine PhD students. He was enormously generous with sharing, exchanging and discussing new research ideas and really appreciated any involvement of his co-workers. He never forced to be popular but always was clear in his opinions, statements and principles. Great passions of Professor Henryk Lamparczyk were history, architecture and music. Dorobek naukowy profesora Henryka Lamparczyka (Publications Or professor Henryk Lamparczyk) Książki (Books) 1. Henryk Lamparczyk, Handbook of Chromatography, Analysis and Characterization of Steroids, Joseph Sherma Editor, CRC Press Boca Raton Florida, 1992. ISBN 0-8493-3008-4. 2. R. Kaliszan, H. Lamparczyk, M. Pankowski, B. Damasiewicz, A. Nasal, J. Grzybowski; A gas chramatographic polarity parameter and its application in studies of quantitative structure-oflactory activity relationships in phenols. In Chromatography, the State of Arts. H. Halasz and L. S. Ettre Eds., Akademiai Kiado Budapest 1985, ISBN 963-05-4089-4, pages 679-695. 3. L. Konieczna, H. Lamparczyk; Wpływ płci na farmakokinetykę wybranych leków. W Statystyka i data mining w badaniach naukowych. Kraków, StatSoft Polska 2005, ISBN 83-88724-28-2, strony 33-52. 4. A. Chmielewska, H. Lamparczyk; Natural cyclodextrins: development in theory, chromatography and pharmacy. In Supramolecular Chemistry and Advanced Materials. Wojciech Macyk & Konrad Szaciłowski, Editors, Kraków Jagielonian University 2007, ISBN-978-83-9244-98-1-2, pages 131-136. 5. L. Konieczna, H. Lamparczyk; Wpływ płci na farmakokinetykę wybranych leków. W zastosowanie metod statystycznych w badaniach naukowych III. Kraków, Statsoft Polska 2008, ISBN 978-83-88724-38-1, strony 299-310. Prace oryginalne (Reserch papers) 1. A. Radecki, H. Lamparczyk; Determination of silicon in lower alkoxy-, allilo-, silane. Chemia Analityczna 19, 457, 1974. 2. J. Łukasiak, A. Radecki, H. Lamparczyk; Organosilicon derivatives of p-aminosalicylic acid. Roczniki Chemii 48, 891, 1974. 3. A. Radecki, H. Lamparczyk, J. Halkiewicz, Z. Jamrógiewicz; A kinetic study of hydrolysis of methyl- 2- trimethylsiloxybenzoate. Roczniki Chemii 48, 811, 1974. 4. J. Łukasiak, Z. Jamrógiewicz, H. Lamparczyk, R. Piękoś; Methyl silicon derivatives of ethyl p- hydroxybenzoate. Acta Pol. Pharm. 32, 429, 1975. 5. A. Radecki, H. Lamparczyk, J. Halkiewicz On the rate of hydrolysis of trimethylphenoxysilane. J. Organometal. Chem. 77, 307, 1974. 6. A. Radecki, H. Lamparczyk, J. Grzybowski, J. Halkiewicz; Acid interferences in indirect determination of silicon by atomic absorption spectroscopy. Spectroscopy Letters 7, 627,1974. 7. A. Radecki, P. Bednarek, J. Bołtrukiewicz, R. Cacha, W. Rapicki, J. Grzybowski, J. Halkiewicz, H. Lamparczyk; Analysis of an industrial smoke preparations. Part I. Separation and identyfication of some high-boiling phenolic fractions. Bromat. Chem. Toksykol. 8, 179, 1975. Camera Separatoria Vol. 5, No 1/2013

Wspomnienie o profesorze Henryku Lamparczyku 37 8. A. Radecki, J. Halkiewicz, H. Lamparczyk, J. Grzybowski, P. Bednarek, J. Bołtrukiewicz, R. Cacha, W. Rapicki; Analysis of an industrial smoke preparation. Part II. Separation and identification of some lowboiling phenolic fractions. Bromat. Chem. Toksykol. 8, 185,1975. 9. A. Radecki, H. Lamparczyk, J. Grzybowski, J. Halkiewicz, P. Bednarek, J. Bołtrukiewicz, W. Rapicki; Analysis of an industrial smoke preparation. Part III. Separation and identification of some low-boiling phenolic fraction components. Bromat. Chem. Toksykol. 9, 327, 1976. 10. A. Radecki, J. Grzybowski, J. Halkiewicz, H. Lamparczyk, P. Bednarek, J. Bołtrukiewicz, W. Rapicki Analysis of an industrial smoke preparation. Part IV. Separation and identification of some components significantly influencing organoleptic and preservating properties of smoke preparation. Bromat. Chem. Toksykol. 9, 461, 1976. 11. A. Radecki, J. Grzybowski, J. Halkiewicz, H. Lamparczyk; Isolation and identification of some components of the lower boiling fraction of a commercial smoke flavorings. Acta Alimentaria Polonica 3, 203, 1977. 12. A. Radecki, J. Grzybowski, J. Halkiewicz, H. Lamparczyk; Gas-liquid chromatographic determination of zinc copper and nickel in marine bottom sediments. J. Chromatogr. 151, 259, 1978. 13. A. Radecki, H. Lamparczyk, J. Halkiewicz, J. Grzybowski; Studies on determination of benzo(a)pyrene in smoke flavorings. Acta Alimentaria Polonica 3, 209, 1977. 14. A. Radecki, H. Lamparczyk, J. Grzybowski, J. Halkiewicz; Separation of polycyclic aromatic hydrocarbons and determination of benzo(a)pyrene in liquid smoke preparations. J. Chromatogr. 150, 527, 1978. 15. R. Kaliszan, H. Lamparczyk; A relationship between the connectivity indices and retention indices of polycyclic aromatic hydrocarbons. J. Chromatogr. Sci. 16, 246, 1978. 16. R. Kaliszan, H. Lamparczyk, A. Radecki; A relationship between repression of dimethylnitrosaminedemethylase by polycyclic aromatic hydrocarbons and their shape. Biochem. Pharmacol. 28, 123, 1979. 17. A. Radecki, J. Grzybowski, H. Lamparczyk, A. Nasal; Relationship between retention indices and substituent constants of phenols on polar stationary phases. J. HRC and CC 2, 581, 1979. 18. A. Radecki, H. Lamparczyk, R. Kaliszan; A relationship between retention indices on nematic phase and shape of the molecules of polycyclic aromatic hydrocarbons. Chromatographia 12, 595, 1979. 19. J. Grzybowski, H. Lamparczyk, A. Nasal, A. Radecki A relationship between the retention indices of phenols on polar and non-polar stationary phases. J. Chromatogr. 196, 217, 1980. 20. A. Radecki, H. Lamparczyk, J. Grzybowski, J. Halkiewicz; Gas-chromatographic determination of benzo(a)pyrene in petroleum products used for the manufacture of drugs and cosmetics. Fresenius Z. Anal. Chem. 303, 397, 1980. 21. T. Jankowski, R. Kaliszan, H. Lamparczyk; A computer program for investigation of quantitative relationships between chemical structure and biological activity; Acta Polon. Pharm. 37, 573, 1980. 22. H. Lamparczyk, A. Radecki, J. Falandysz; Separation of polychlorinated biphenyls on liquid crystals and isotropic phases. J. HRC and CC 3, 301, 1980. 23. H. Lamparczyk, A. Radecki, D. Wilczyńska; Determination of average molecular polarizabilities of polycyclic aromatic hydrocarbons directly from retention indices. Chromatographia 14, 707, 1981. 24. H. Lamparczyk, A. Radecki, R. Kaliszan; Application of a geometric parametr defining molecular shape, for the quantitation of interaction of polycyclic aromatic hydrocarbons with enzyme systems. Biochem. Pharmacol. 30, 2337, 1981. 25. R. Kaliszan, M. Pankowski, L. Szymula, H. Lamparczyk, A. Nasal, B. Tomaszewska, J. Grzybowski Structure-olfactory activity relationship in a group of substituted phenols. Pharmazie 37, 499, 1982. 26. H. Lamparczyk, D. Wilczyńska, A. Radecki Relationship between the average molecular polarizabilities of polycyclic aromatic hydrocarbons and their retention indices determined on various stationary phases. Chromatographia 17, 300, 1983. 27. H. Lamparczyk, A. Radecki Lack of evidence for dispersive interaction between polycyclic aromatic hydrocarbons and stationary phases in gas liquid chromatography. J. HRC and CC 6, 390, 1983. 28. H. Lamparczyk, P.B. Farmer, P.D. Cary, P.L. Grover, P. Sims The metabolism of 9,10- dimethylanthracene by rat liver microsomal preparations. Carcinogenesis 5, 1405, 1984. 29. H. Lamparczyk, A. Radecki; The role of electric interactions in retention index concept; Implications in quantitative structure-retention studies. Chromatographia 18, 615, 1984. 30. H. Lamparczyk; Separation of twelve monomethylbenz(a)antracenes on liquid crystal and isotropic stationary phases in relation to the shape of their molecules.j. HRC and CC 8, 90, 1985. 31. J. Halkiewicz, H. Lamparczyk, A. Radecki Behaviour of copper (II) and nickel (II) dialkyldithiocarbamates on polar and non-polar stationary phases. Fresenius Z. Anal. Chem. 320, 577, 1985. 32. R. Kaliszan, H. Lamparczyk, M. Pankowski, B. Damasiewicz, A. Nasal, J. Grzybowski A gas chromatographic polarity parameter and its application in studies of quantitative structure-olfactory activity relationships in phenols. "Chromatography, the state of the art" H. Kalasz and L. S. Ettre (Eds) Vol 2 pp. 679-695. Akademiai Kiado Budapest (1985). Vol. 5, No 1/2013 Camera Separatoria

38 P.K. Zarzycki 33. H. Lamparczyk; The role of electric interactions in the retention index concept. Universal interaction indices for GLC, HPLC and TLC. Chromatographia 20, 283, 1985. 34. H. Lamparczyk; Badania nad strukturalnymi uwarunkowaniami właściwości chemicznych i biologicznych węglowodorów aromatycznych. Acta Polon. Pharm. 42, 497, 1985. 35. H. Lamparczyk, S. McKay, P.B. Farmer, P.D. Cary, P.L. Grover, P. Sims The metabolism of 9- methylanthracene by rat-liver microsomal preparations. Xenobiotica 16, 325, 1986. 36. H. Lamparczyk, R. Kaliszan, A. Radecki Correlation between retention on liquid crystalline phases and chemical structure. J. Chromatogr. 361, 442, 1986. 37. H. Lamparczyk, R. J. Ochocka The role of electric interaction in the retention index concept. Application of the electric interaction indices to quantitative structure-biological activity studies of monomethylbenz (a) anthracenes. Chromatographia 21, 409, 1986. 38. J. Jadżyn, K. Pralat, D. Wilczyńska, H. Lamparczyk Dipole moments and induction effects in series of polychlorinated biphenyls. Polish J. Chem. 59, 1255, 1985. 39. H. Lamparczyk, R. J. Ochocka; Electrostatic interactions in normal and reversed-phase highperformance thin-layer chromatography. Preliminary experiments. Chromatographia 23, 337, 1987. 40. J. Halkiewicz, H. Lamparczyk, J. Grzybowski, A. Radecki; On the aliphatic and polycyclic aromatic hydrocarbons levels in the Southern Baltic Sea atmosphere. Atmospheric Environment 21, 2057, 1987. 41. H. Lamparczyk, T. Nagoshi, K. Jinno; Application of the electrostatic interaction concept for the study of the retention behaviour of peropyrene-type polycyclic aromatic hydrocarbons in reversed-phase liquid chromatography. Chromatographia 23, 473, 1987. 42. J. Grzybowski, J. Halkiewicz, H. Lamparczyk, A. Radecki; The determination of aliphatic and polycyclic aromatic hydrocarbons in water from the Southern Baltic Sea. Marine Poll. Bull. 18, 247, 1987. 43. H. Lamparczyk, M. Atomura, K. Jinno; Qualitative description of dispersive and inductive electrostatic interactions in reversed-phase liquid chromatography. Chromatographia 23, 752, 1987. 44. H. Lamparczyk, R.J. Ochocka, J. Grzybowski, J. Halkiewicz, A. Radecki Parameters related to marine environment pollution derived from n-alkanes and polycyclic aromatic hydrocarbons concetrations in Baltic Sea waters and sediments. Marine Poll. Bull. 19, 222, 1988. 45. K. Jinno, T. Ibuki, H. Lamparczyk, M. Okamoto, N. Tanaka, J. C. Fetzer, W. R. Biggs; Study on retention behaviour of peropyrene-type polycyclic aromatic hydrocarbons with various bonded stationary phases in reversed-phase liquid chromatography. Chromatographia 25, 483, 1988. 46. H. Lamparczyk, R. J. Ochocka; Study of dispersive and inductive electrostatic interactions in reversedphase thin-layer chromatography. Chromatographia 25, 643, 1988. 47. H. Lamparczyk, R. J. Ochocka, P. Zarzycki; Evidence for electrostatic interactions of steroids in thinlayer chromatography. Chromatographia 27, 565, 1989. 48. H. Lamparczyk, M. Wesołowski; Application of principal component analysis and thermoanalytical methods in evaluation of edible fish oils. Thermochim. Acta 155, 327, 1989. 49. H. Lamparczyk, R. J. Ochocka, P. Zarzycki, J. P. Zieliński; Separation of steroids by reversed-phase HPTLC using various binary mobile phases. J. Planar Cromatogr. 3, 34, 1990. 50. H. Lamparczyk, M. Wesołowski Application of principal component analysis and thermoanalytical methods in evaluation of lube oils. Thermochim. Acta 159, 235, 1990. 51. H. Lamparczyk, P. Zarzycki, R. J. Ochocka, D. Sybilska; Structure-retention studies on the inclusion complex formation of some polycyclic aromatic hydrocarbons with beta-cyclodextrin. Chromatographia 30, 91, 1990. 52. H. Lamparczyk, R. J. Ochocka, J. Grzybowski, J. Halkiewicz, A. Radecki; Classification of Marine Environment Samples Based on Chromatographic Analysis of Hydrocarbons and Principal Component Analysis. Oil & Chemical Pollution 6, 177, 1990. 53. R.J. Ochocka, M. Wesołowski, H. Lamparczyk; Thermoanalysis supported by principal component analysis of essential oil samples. Thermochim. Acta 173, 199-210, 1990. 54. A. Lebiedzińska, H. Lamparczyk, Z. Ganowiak, K.I. Eller; Differences in biogenic amine patterns in fish obtained from commercial sources. Z. Lebensm. Unters. Forsch. 192, 240-243, 1991. 55. H. Lamparczyk, P. Zarzycki, R.J. Ochocka, M. Asztemborska, D. Sybilska; Retention behaviour of the inclusion complexes of some polycyclic aromatic hydrocarbons with beta-cyclodextrin. Chromatographia 31, 157-162, 1991. 56. H. Lamparczyk, M. Miszkiel; Gas chromatographic evaluation of wool wax alcohols supported by principal component analysis. Chromatographia 31, 243-246, 1991. 57. H. Lamparczyk, M. Miszkiel, M. Wesołowski; Thermoanalytical and gas-chromatographic evaluation of wool wax alcohols supported by principal component analysis. Thermochem. Acta 179, 177-185, 1991. 58. T. M. Traczewska, R. Ochocka, H. Lamparczyk; The metabolism of anthracene and 9,10- dimethylanthracene by bacteria isolated from waters. Acta Microbiologica Polonica 40, 235-241, 1991. 59. R. J. Ochocka, M. Wesołowski, H. Lamparczyk; Thermoanalysis supported by principal component analysis (PCA) in quality assessment of essential oil samples. Thermochem. Acta 210, 151-162, 1992. 60. P. Zarzycki, A. Jankowski, J. Nowakowska, H. Lamparczyk; Oznaczanie estrogenów w moczu metodą wysokosprawnej chromatografii cieczowej. Problemy Terapii Monitorowanej, 3, 148-152, 1992. Camera Separatoria Vol. 5, No 1/2013

Wspomnienie o profesorze Henryku Lamparczyku 39 61. R. J. Ochocka, A. Marzec, H. Lamparczyk; Fluorescence enhancement of two terpenes commonly present in essential oils. J. Pharm. Biomed. Anal. 10, 809-812, 1992. 62. A. Jankowski, A. Marzec, H. Lamparczyk; Comparative bioavailability of verapamil from rapidly absorbed and slow release preparation. J. Pharm. Biomed. Anal. 10, 1101-1103, 1992. 63. R. J. Ochocka, H. Lamparczyk; Evaluation of essential oils from the family Umbelliferae using principal component analysis. Pharmazie 48, 229-230, 1993. 64. D. Sybilska, M. Asztemborska, A. Bielajewska, J. Kowalczyk, H. Dodziuk, K. Duszczyk, H. Lamparczyk, P. Zarzycki; Chromatographic studies on the inclusion of isomeric dimethylnaphthalenes by gamma and beta cyclodextrin. Chromatographia 35 637-642, 1993. 65. A. Jankowski, A. Marzec, A. Skorek, H. Lamparczyk High-performance liquid chromatographic determination of glibenclamide in biological material. Acta Chromatographica 2, 33-39, 1993. 66. H. Lamparczyk, P. K. Zarzycki, J. Nowakowska, R. J. Ochocka; Application of beta-cyclodextrin for the analysis of estrogenic steroids in human urine by high-performance liquid chromatography. Chromatographia 38, 168-172, 1994. 67. R. J. Ochocka, M. Asztemborska, J. Kowalczyk, H. Lamparczyk;Gas-chromatographic evaluation of essential oils supported by principal component analysis. Pharmazie 49, 287-288, 1994. 68. A. Skorek, A. Marzec, A. Jankowski, H. Lamparczyk, M. Linka, M. Ziółkowski, J. Rybakowski Farmakokinetyka kliniczna klozapiny po jednorazowym i wielokrotnym podaniu leku. Problemy Terapii Monitorowanej, 5, 47-49, 1994. 69. D. Sybilska, J. Kowalczyk, M. Asztemborska, R. J. Ochocka, H. Lamparczyk; Chromatographic studies of the enantiomeric composition of some therapeutic compositions applied in the treatment of liver and kidney diseases. J. Chromatogr. A, 665, 67-73, 1994. 70. H. Lamparczyk, P. K. Zarzycki, J. Nowakowska; Effect of temperature on separation of norgestrel enantiomers by high-performance liquid chromatography. J. Chromatogr. A, 668, 413-417, 1994. 71. A. Jankowski, H. Lamparczyk; Evaluation of chromatographic methods for the determination of nifedipine in human serum. J. Chromatogr. A, 668, 469-473, 1994. 72. P. K. Zarzycki, J. Nowakowska, A. Radecki, A. Jankowski, H. Lamparczyk; Oznaczanie kwasu nikotynowego w osoczu krwi metodą HPLC. Problemy Terapii Monitorowanej, 5, 84-90, 1994. 73. H. Lamparczyk, P. K. Zarzycki; Effect of temperature on separation of estradiol stereoisomers and equilin by liquid chromatography using mobile phases modified with beta-cyclodextrin. J. Pharm. Biomed. Anal. 13, 543-549, 1995. 74. A. Jankowski, A. Skorek, K. Krzyśko, P. K. Zarzycki, R. J. Ochocka, H. Lamparczyk; Captopril: determination in blood and pharmacokinetics after single oral dose. J. Pharm. Biomed. Anal. 13, 655-660, 1995. 75. A. Skorek, A. Jankowski, H. Lamparczyk; Application of HPLC for doxepine determination in pharmacokinetic studies. Acta Chromatographica 4, 109-116, 1995. 76. P. K. Zarzycki, J. Nowakowska, A. Chmielewska, H. Lamparczyk; Retention properties of cyclodextrins in reversed phase HPTLC, J. Planar Chromatogr. 8, 227-231, 1995. 77. P. K. Zarzycki, P. Kowalski, J. Nowakowska, H. Lamparczyk; High-performance liquid chromatographic and capillary electrophoretic determination of free nicotinic acid in human plasma and separation of its metabolites by capillary electrophoresis. J. Chromatogr. A, 709, 203-208, 1995. 78. R. J. Ochocka, D. Rajzer, P. Kowalski, H. Lamparczyk; Determination of coumarins from Chrysanthemum segetum L. by capillary electrophoresis. J. Chromatogr. 709, 197-202, 1995. 79. A. Jankowski, A. Skorek-Jankowska, L. Warda, M. Steinborn-Piotrzkowska, H. Lamparczyk. Application of HPLC for bezafibrate determination in biological fluids. Acta Chromatographica 5, 151-157, 1995. 80. A. Jankowski, A. Skorek-Jankowska, H. Lamparczyk; Simultaneous determination of spironolactone and its metabolites in human plasma. J. Pharm. Biomed. Anal. 14, 1359-1365, 1996. 81. P. K. Zarzycki, M. Wierzbowska, H. LamparczykThe influence of temperature on the high-performance liquid chromatographic separation of steroids using mobile phases modified with beta-cyclodextrin. J. Pharm. Biomed. Anal. 14, 1305-1311, 1996. 82. P. K. Zarzycki, H. Lamparczyk; A simple experiment demonstrating the temperature effect in supramolecular chemistry. J. Chem. Educ. 73, 459-460, 1996. 83. P. K. Zarzycki, J. Nowakowska A. Chmielewska, H. Lamparczyk; Retention properties of cyclodextrins on polyamide TLC. J. Planar Chromatogr. 8, 260-263, 1996. 84. H. Lamparczyk, P. Kowalski, D. Rajzer, J. Nowakowska; Determination of piracetam in human plasma by capillary electrophoresis. J. Chromatogr. B, 692, 483-487, 1997. 85. A. Jankowski, A. Skorek-Jankowska, H. Lamparczyk; Determination and pharmacokinetics of a furosemide-amiloride drug combination. J. Chromatogr. B, 693, 383-391, 1997. 86. P. K. Zarzycki, M. Wierzbowska, H. Lamparczyk; The influence of temperature on the multiple separation of estrogenic steroids using mobile phases modified with beta-cyclodextrin in highperformance liquid chromatography. J. Pharm. Biomed. Anal. 15, 1281-1287, 1997. 87. P. K. Zarzycki, J. Nowakowska, A. Chmielewska, M. Wierzbowska H. Lamparczyk Thermodynamic study of the retention behaviour of selected macrocycles using reversed-phase high-performance thin- Vol. 5, No 1/2013 Camera Separatoria

40 P.K. Zarzycki layer chromatography plates and methanol-water mobile phases. J. Chromatogr. A, 787, 227-233, 1997. 88. A. Jankowski, H. Lamparczyk, K. Pawlik Ocena biorównoważności preparatu Hepatil-saszetki w porównaniu z OLB. Terapia i leki, Rok 1997/XXIV/XLVII/6. 89. P.K. Zarzycki, H. Lamparczyk; Evidences for Temperature-Dependent Mechanism of Host-Guest Complexation. Chromatographia 48, 377-382, 1998 90. P.K. Zarzycki, H. Lamparczyk; The equilibrium constant of -cyclodextrin- phenolphtalein complex; influence of temperature and tetrahydrofuran addition; J. Pharm. Biomed. Anal. 18, 165-170, 1998. 91. A. Jankowski, A.L. Jankowska, H. Lamparczyk; Determination and pharmacokinetics of acyclovir after ingestion of suspension form. J. Pharm. Biomed. Anal. 18, 249-254, 1998. 92. P. K. Zarzycki, M. Wierzbowska, J. Nowakowska, A. Chmielewska, H. Lamparczyk; Interactions between native cyclodextrins and n-alcohols studied using thermostated thin-layer chromatography. J. Chromatogr. A, 839,149-156, 1999. 93. P. Kowalski, I. Olędzka, P. Okoniewski, M. Switała, H. Lamparczyk; Determination of streptomycin in eggs yolk by capillary electrophoresis. Chromatographia, 50, 101-104, 1999. 94. P.K. Zarzycki, M. Wierzbowska, H. Lamparczyk; Retention and separation studies of cholesterol and bile acids using thermostated thin-layer chromatography; J.Chromatogr.A, 857, 255-262, 1999. 95. A. Jankowski, H. Lamparczyk, B. Szefler, E. Nartowicz, M. Woźnicki, E. Sikorska.Ocena równoważności biologicznej preparatu Flutamid tabl. 250 mg w porównaniu z odpowiednikiem leku badanego. Terapia i leki,1-2, 37-39, 1999. 96. H. Lamparczyk, P. Kowalski. Zastosowanie elektroforezy kapilarnej w analizie leków. Biuletyn Instytutu Leków, 44, (1), 126-127, 2000. 97. H. Lamparczyk, A. Jankowski, E. Nartowicz, M. Woźnicki; Ocena równoważności biologicznej preparatu Cipronex w porównaniu z preparatem Ciprobay. Medycyna po Dyplomie. Wydanie specjalne, 12-14, Maj 2000. 98. P.K. Zarzycki, H. Lamparczyk; Temperature Controlled Thin-Layer Chromatography. Chem. Anal. (Warsaw), 46, 469-475, 2001. 99. H. Lamparczyk, A. Chmielewska, L. Konieczna, A. Plenis, P. K. Zarzycki; RP-HPLC method with electrochemical detection for the determination of metoclopramide in serum and its use in pharmacokinetic studies. Biomed. Chromatogr. 15, 513-517, 2001. 100. P. Kowalski, I. Olędzka, H. Lamparczyk; Capillary electrophoresis in analysis of veterinary drugs. J. Pharm. Biomed. Anal., 32, 937-947, 2003 101. P. Kowalski, M. Bieniecki, I. Olędzka, H. Lamparczyk; Validated capillary electrophoretic method for the analysis of ivermectin in plasma after intragastric administration in pigs and horses. Biomed. Chromatogr., 18, 302-310, 2004 102. P. Kowalski, A. Chmielewska, L. Konieczna, I. Olędzka, P.K. Zarzycki, H. Lamparczyk, The bioequivalence study of baclofen and lioresal tablets using capillary electrophoresis. Biomed. Chromatogr., 18, 310-317, 2004 103. P.K. Zarzycki, K.M. Kulhanek, R. Smith, M.A. Bartoszuk, H. Lamparczyk. Planar Chromatography Versus Column Chromatography: A Performance Comparison. LCGC North America, 23, (3), 286-300, 2005. 104. P. Kowalski, L. Konieczna, A. Chmielewska, I. Olędzka, A. Plenis, M. Bieniecki, H. Lamparczyk Comparative evaluation between capillary electrophoresis and high-performance liquid chromatography for the analysis of florfenicol. J. Pharm. Biomed. Anal., 39, 983-989, 2005. 105. L. Konieczna, H. Lamparczyk. Wpływ płci na farmakokinetykę wybranych leków. Statystyka i data mining w badaniach naukowych, Wyd. Stat-Soft, Warszawa-Kraków 2005, 33-52. 106. A. Chmielewska, L. Konieczna, A. Plenis, M. Bieniecki, H. Lamparczyk. Determination of diclofenac in plasma by high-performance liquid chromatography with electrochemical detection. Biomed. Chromatogr., 20, 119-124, 2006. 107. P. Kowalski, M. Bieniecki, I. Olędzka, H. Lamparczyk. Validated method for L-ornithine-L-aspartate analysis in human plasma by capillary electrophoresis. Biomed. Chromatogr., 20, 185-194, 2006. 108. A. Chmielewska, L. Konieczna, A. Plenis, H. Lamparczyk. Quantitative determination of pentoxifylline in human plasma. Acta Chromatogr., 16, 70-79, 2006. 109. A. Chmielewska, L. Konieczna, H. Lamparczyk. Development of a reversed-phase HPLC-method for analysis of fluocinolone acetonide in gel and ointment. Acta Chromatogr., 16, 80-91, 2006 110. L. Konieczna, A. Chmielewska, H. Lamparczyk. Influence of sex on the pharmacokinetics of ciprofloxacin and ofloxacin. Chemotherapy, 52, 111-121, 2006 111. A. Chmielewska, L. Konieczna, A. Plenis, H. Lamparczyk. Sensitive quantification of chosen drugs by reversed-phase chromatography with electrochemical detection at a glassy carbon electrode. J. Chromatogr. B, 839, 102-111, 2006 112. A. Plenis, A. Chmielewska, L. Konieczna, H. Lamparczyk. A validated high-performance liquid chromatographic method for the determination of moclobemide and its two metabolites in human plasma and application to pharmacokinetic studies. Biomed. Chromatogr. 21, 958-966, 2007. Camera Separatoria Vol. 5, No 1/2013

Wspomnienie o profesorze Henryku Lamparczyku 41 113. A. Chmielewska, H. Lamparczyk; Mass versus mole doses, similarities and differences. Pharmazie 63, 843-847, 2008. 114. A. Chmielewska, L. Konieczna, A. Plenis, T. Bączek, H. Lamparczyk. Rapid and sensitive RP-LC method with amperometric detection for pharmacokinetic assessment of propafenone in human serum of healthy volunteers. J. Anal. Chem.2010; vol. 65, nr 11, s. 1164-1169 115. Aleksandra Chmielewska, Lucyna Konieczna, Henryk Lamparczyk. Oznaczanie enrofloksacyny w osoczu krwi zwierzęcej metodą RP-HPLC z detekcją fluorymetryczną. Bromat. Chem. Toksykol. XLIV, 2011, 3, str. 742 747. Vol. 5, No 1/2013 Camera Separatoria