XIII Congress of the Polish Transplantation Society

XIII Congress of the Polish Transplantation Society THURSDAY, 12 OCTOBER 2017 ROOM 1 ROOM 2 ROOM 3 ROOM 4 10.00 12.00 Business Meeting of the PTS Managing Board 12.30 14.00 Joint session I of Poltransplant and Polish Society of Transplant Coordinators Head: Artur Kamiński, Roman Danielewicz, Jarosław Czerwiński Meeting of the Board of Regional Consultants 1. 12.30 12.45 Updates in legislation concerning Artur Kamiński 2. 12.45 13.00 Diagnosis and confirmation of death according to the current law. Romuald Bohatyrewicz Romuald Bohatyrewicz (Szczecin) 3. 13.00 13.15 Hospital stratification by donation potential. Network of transplant coordinators in Poland Teresa Danek, Anna Pszenny 4. 13.15 13.30 Organ harvesting from foreign nationals deceased while staying in Poland Jarosław Czerwiński 5. 13.30 13.45 Cornea harvesting from deceased donors Dorota Polak

6. 13.45-14.00 Recruitment of bone marrow donors Tigran Torosian (DKMS Polska, Warsaw) 14.00 14.30 Break 14.30 16.00 Joint session II of Poltransplant and Polish Society of Transplant Coordinators Head: Krzysztof Pabisiak, Wojciech Czapiewski, Romuald Bohatyrewicz 1. 14.30 14.50 Polish Society of Transplant Coordinators Wojciech Czapiewski (Poznań) 2. 14.50 15.50 What s good and what s bad in coordination of organ and tissue harvesting? Krystyna Antoszkiewicz (Poltransplant coordinator, Warsaw), Krzysztof Pabisiak (regional coordinator, Szczecin), Filip Szeremeta (hospital coordinator, Cieszyn), Aleksandra Kaczorowska (tissue transplant coordinator) 3. 15.50 16.00 European Commission. European praxis in organ donation and transplant Jarosław Czerwiński Transplant nursing Head: Piotr Małkowski, Roman Danielewicz, Marta Hreńczuk 1. 14.30 14.55 Nurse s role in preventing development of posttransplant diabetes in kidney graft recipients Beata Białobrzeska (Gdańsk) 2. 14.55 15.20 Implementation of the ERAS protocol and nursing of kidney graft recipients Irena Milaniak (Cracow) 3. 15.20 15.45 Nursing in extracorporeal management of liver failure before transplant Marta Hreńczuk 4. 15.45 16.00 Discussion 14.30 15.30 Polish Union of Transplantation Medicine meeting 15:30 16:00 General Meeting of the Polish Society for Organ Donation 16.00 17.00 Press conference 17.00 17.25 Opening ceremony Head: Krzysztof Zieniewicz (Warszawa), Piotr Przybyłowski (Kraków) 1. 17.00 17.10 Welcome address Krzysztof Zieniewicz (Warszawa)

2. 17.10 17.25 Speeches by the invited guests 17.25 18.25 Inaugural lectures 1. 17.25 17.45 Memories of Professor Mieczysława Lao Magdalena Durlik (Warszawa) 2. 17.45 18.05 Lecture by invitation of President of PTT PAN Harvard UCLA in 40 years: Reflection of a doctor and scientist in organ Jerzy Kupiec-Węgliński (Los Angeles, USA) 3. 18.05 18.25 Wojciech Rowiński lecture Is obesity a significant risk factor in a living kidney donor? Andrzej Więcek (Katowice) 18.25 18.40 18.25 18.40 The award ceremony of Polish Transplantation Society Pro Transplantationibus Fovendis and PTT grant adjudication 18.40 19.10 Welcome cocktail (extra paid participation) 19.10 20.00 Myrczek & Tomaszewski band concert Palm Jazz (extra paid participation) FRIDAY, 13 OCTOBER 2017 ROOM 1 ROOM 2 ROOM 3 ROOM 4 08.30 10.00 Plenary session I: Basic science in transplantology Long-term results in pancreas Bone marrow part I Head: Wiesław Jędrzejczak, Andrzej Post-transplant malignancy Head: Alicja Dębska-Ślizień,, Sławomir

Head: Jolanta Małyszko, Andrzej Więcek, Andrzej Górski, Leszek Pączek 1. 8.30 8.50 Bright future or requiem for biomarkers in transplantology? Jolanta Małyszko (Białystok) 2. 8.50 9.10 Progress in transplantology. From benchmark to bedside Andrzej Więcek (Katowice) 3. 9.10 9.30 Phage therapy from symptomatic treatment to curative therapy Andrzej Górski 4. 9.30 9.50 What can transplantology learn from other sciences? Leszek Pączek 5. 9.50 10.00 Discussion Head: Lech Cierpka, Marek Durlik, Tadeusz Grochowiecki 1. 8.30 8.45 Introduction. Reports of pancreas transplanting in Polish hospitals from Polish and international journals Lech Cierpka (Katowice) 2. 8.45 9.00 What protocol is optimal in kidney transplant for end-stage renal failure due to type 1 diabetes? Tadeusz Grochowiecki 3. 9.00 9.15 Pancreas and island transplant is there evidencebased benefit over insulin therapy? Marek Durlik 4. 9.15 9.30 Report on pancreas transplanting in Polish centres Wojciech Lisik Hellmann, Piotr Rzepecki 1. 8.30 8.50 Bone marrow in myeloproliferative neoplasia 2017 Andrzej Hellmann (Gdańsk) 2. 8.50 9.10 Bone marrow in autoimmune disease 2017 Emilian Snarski 3. 9.10 9.30 Bone marrow transplant complications Piotr Rzepecki 4. 9.30 9.50 Haploidentical bone marrow transplant 2017 Wiesław Jędrzejczak 5. 9.50 10.00 Discussion Lizakowski 1. 8.30 8.50 Viral infections and malignancy development in graft recipients Magdalena Durlik 2. 8.50 9.00 Post-transplant lymphoproliferative disorder in liver graft recipient diagnostic pitfalls Renata Wieczorek-Godlewska 3. 9.00 9.20 Are current kidney cancer therapy standards satisfactory? Anna Kowalczyk (Gdańsk) 4. 9.20 9.30 Systemic therapy in post-transplant malignancy. Case report Katarzyna Sosińska-Mielcarek (Gdańsk) 5. 9.30 9.45 Pancreas and long-term diabetes complications Jacek Ziaja (Katowice) 6. 9.45 10.00 Discussion Lech Cierpka (Katowice), Marek Durlik, Tadeusz Grochowiecki, Wojciech Lisik, Jacek Ziaja (Katowice) 5. 9.30 9.50 Squamous cell carcinoma in organ transplant recipients etiopathogenesis, clinics and management Agnieszka Cegielska (Gdańsk) 6. 9.50 10.00 Invasive squamous cell carcinoma of skin in kidney graft recipient Aleksandra Okuniewska (Gdańsk) 10.00 10.30 Coffee break 10.30 12.00 Kidney part I Head: Andrzej Oko, Zbigniew Włodarczyk, Michał Nowicki Symposium sponsored by Chiesi. Challenges in immunosuppression Head: Magdalena Durlik 1. 10:30-10:35 Welcome Thoracic organ part I Head: Michał Zakliczyński, Mariusz Kuśmierczyk, Tomasz Zieliński Therapeutic monitoring of immunosuppression in organ transplantology Head: Tomasz Pawiński, Paweł Kunicki, Mercè Brunet Magdalena Durlik (Warszawa)

1. 10.30 10.50 Organ donor diagnosed with malignancy what to do? Alicja Dębska-Ślizień (Gdańsk) 2. 10.50 11.10 Perioperative disorders of homeostasis in patients with kidney failure Janusz Trzebicki 3. 11.10 11.30 Vascular and endoluminal procedures in kidney graft recipients Sławomir Nazarewski 4. 11.30 11.50 Kidney transplant in children with lower urinary tract dysfunction Dorota Broniszczak-Czyszek 5. 11.50 12.00 Discussion 2. 10:35-11:00 Differences between formulations of tacrolimus and their relevance to pharmacokinetics Marek Myślak (Szczecin) 3. 11:00-11:25 Patient with fast metabolism of tacrolimus how to identify them and improve the outcomes of treatment Magdalena Durlik (Warszawa) 4. 11:25-11:50 Patient with fast metabolism of tacrolimus how to identify them and improve the outcomes of treatment Ilona Kurnatowska (Łódź) 5. 11:50-12:00 Discussion 1. 10.30 10.42 Qualification for cardiac transplant in patients on circulatory support Małgorzata Sobieszczańska-Małek 2. 10.42 10.54 Cardiac transplant in patients on mechanic circulatory support surgeon s challenge Mariusz Kuśmierczyk 3. 10.54 11.06 Mechanic circulatory support and cardiac in children. When to expect regeneration? Szymon Pawlak (Zabrze) 4. 11.06 11.18 Perioperative care in cardiac transplant recipient previously treated with various circulatory support modalities Paweł Nadziakiewicz (Zabrze) 5. 11.18 11.36 Case presentations 6. 11.36 12.00 Discussion 1. 10.30 10.55 Clinical utility of biomarkers assay in Mercè Brunet (Barcelona) 2. 10.55 11.15 Therapeutic monitoring of immunosuppression in kidney and liver tissue is it worth it? Tomasz Pawiński 3. 11.15 11.40 Interactions of immunosuppressive agents as therapeutic challenge in transplantology Paweł Kunicki 4. 11.40 11.50 Hot news 15th International Congress of Therapeutic Drug Monitoring & Clinical Toxicology (Kyoto, Japan, 24 27.09.2017) Tomasz Pawiński 5. 11.50 12.00 Discussion Małgorzata Sobieszczańska-Małek, Piotr Siondalski (Gdańsk), Paweł Nadziakiewicz (Zabrze), Szymon Pawlak (Zabrze), Janusz Skalski (Cracow), Mariusz Kuśmierczyk, Michał Zembala (Zabrze) 12.00 12.30 Coffee break 12.30 14.00 Liver part I Head: Krzysztof Zieniewicz, Lech Cierpka, Piotr Kaliciński Session by Astellas: Optimization of immunosuppression Head: Marian Klinger Transplant immunology 2017 Head: Radosław Zagożdżon, Piotr Trzonkowski, Krzysztof Mucha Infections in transplantology Head: Magdalena Durlik, Sławomir Nazarewski, 1. 12.30 12.50 Liver for HCC 20 years after introducing the Milan criteria Pierre-Alain Clavien (Zurich) 1. 12:30-12:35 Welcome and introduction Marian Klinger (Wroclaw) 1. 12.30 12.45 Does a transplant recipient need immunosuppressive therapy? Krzysztof Mucha 1. 12.30 12.50 Management of type C hepatitis in liver graft recipients in the age of directly acting antiviral therapy Alicja Wiercińska-Drapało

2. 12.50 13.05 HCC in patients with NASH a new challenge worldwide Joanna Raszeja-Wyszomirska 3. 13.05 13.20 Liver transplant for malignant disease from donors after cardiac death (DCD) Wojciech Polak (Rotterdam) 4. 13.20 13.35 Indications and results of liver for HCC in own experience Waldemar Patkowski 5. 13.35 13.50 Primary liver tumours as an indication for liver transplant in children Piotr Kaliciński 6. 13.50 14.00 Discussion 2. 12:35-13:00 Optimization of immunosuppression after kidney Marian Klinger (Wroclaw) 3. 13:00 13:25 Optimization of immunosuppression after liver Marta Wawrzynowicz-Syczewska (Szczecin) 4. 13:25 13:45 Long-term outcomes in - comparative pharmacokinetics of different tacrolimus formulations Dr Nas Undre (Astellas Pharma Europe, UK) 5. 13:45 13:55 Discussion panel 6. 13:55 14:00 Summary Marian Klinger (Wroclaw) 2. 12.45 12.50 Discussion 3. 12.50 13.05 Post-transplant acceptance or tolerance? Piotr Trzonkowski (Gdańsk) 4. 13.05 13.10 Discussion 5. 13.10 13.25 Advanced therapy outcomes per aspera ad astra Dariusz Śladowski 6. 13.25 13.30 Discussion 7. 13.30 13.45 Inhibition of acute rejection and prolonged immunological tolerance of skin graft in rats through autologous stem cell and clonal lymphocyte depletion Emilian Snarski 8. 13.45 13.55 Evaluation of pretransplant donor specific alloantibodies with different crossmatch techniques Maciej Zieliński (Gdańsk) 2. 12.50 13.10 Infections with multidrug resistant bacteria in recipients of vascularised organs new challenges Dariusz Kawecki (Waraw) 3. 13.10 13.30 Polyoma BK virus infection in kidney graft recipients Dominika Dęborska-Materkowska 4. 13.10 13.30 Polyoma BK virus infection in kidney graft recipients Sławomir Nazarewski 5. 13.50 14.00 Discussion 9. 13.55 14.00 Discussion 14.00 15.30 Lunch, poster session 15.30 17.00 Plenary session II: Harvesting and of organs from donors after cardiac death Head: Maciej Kosieradzki, Wojciech Polak 1. 15.30 15.45 Legal aspects of organ harvesting after cardiac death. Is it possible to use organs from Maastricht 3 category donors? Ewa Guzik-Makaruk (Białystok) Symposium sponsored by Roche Symbiosis of theory and practice the key to optimal immunosuppression 1. Registration of immunosuppressive drugs EMA regulations Paweł Kunicki (Warszawa) 2. Strategy for monitoring mycophenolic acid how to avoid mistakes Legal and ethical aspects Head: Krzysztof Zieniewicz, Lech Cierpka, Bolesław Rutkowski 1. 15.30 15.50 Bioethical boundaries in transplantology Krzysztof Szczechowski (Katowice) 2. 15.50 16.10 Organ trading myth or reality? We need to act! Roman Danielewicz Corneal Head: Jacek Szaflik, Iwona Grabska-Liberek, Jerzy Szaflik 1. 15.30 15.45 Corneal harvesting in Poland, experience from the Ocular Tissue Bank in Warsaw Iwona Grabska-Liberek, Dorota Polak, Anna Matejak, Beata Luty Tomasz Pawiński (Warszawa)

2. 15.45 16.00 ECMO programme in the Wielkopolska region how to save lives and promote organ donation at the same time? Mateusz Puślecki (Poznań) Marek Jemielity (Poznań) 3. 16.00 16.15 Are organs from donors after cardiac death worth grafting? Marek Karczewski (Poznań) 4. 16.15 16.30 Futile therapy Grzegorz Niewiński 5. 16.30 16.45 Donor pool and results of from donors after expected cardiac death (Maastricht 3) Wojciech Polak (Rotterdam) 6. 16.45 17.00 Discussion 3. Optimal use of mycophenolate mofetil in the immunosuppression program in renal transplant recipients Marian Klinger (Wrocław) 4. Regimens of immunosuppression in prevention and treatment of transplant recipient immunization Magdalena Durlik (Warszawa) 5. MMF in children on non-steroidal immunosuppression and noncompliant adolescents Ryszard Grenda (Warszawa) 6. Safety of MMF therapy the clinician's point of view Kazimierz Ciechanowski (Szczecin) 7. Panel discussion, Q & A 3. 16.10 17.00 Expert panel discussion Moderators: Bolesław Rutkowski (Gdańsk), Krzysztof Szczechowski (Katowice), Roman Danielewicz Panelists: Ewa Guzik-Makaruk (Białystok), Paweł Łuków, Katarzyna Kowal (Poznań), Danuta Ślęczek-Czakon (Katowice) 2. 15.45 16.00 Emergency corneal Ewa Mrukwa-Kominek (Katowice), Łukasz Drzyzga, Karol Krycia 3. 16.00 16.15 Evolution of indications for corneal Jacek P. Szaflik, Monika Łazicka-Gałecka, Monika Udziela, Małgorzata Sybilska, Justyna Izdebska, Grażyna Minkiewicz, Jerzy Szaflik 4. 16.15 16.30 Current aspects of treatment of diseases in transplanted cornea Joanna Major, Monika Łazicka-Gałecka, Justyna Izdebska, Mieczysław Lao, Jacek P. Szaflik 5. 16.30 16.45 How to initiate a hospital corneal transplant programme? Mysteries unveiled Marcin Stopa (Poznań), Piotr Przygoda 6. 16.45 17.00 Discussion 17.00 17.30 Registration and verification of PTS members 17.30 19.00 General Assembly of the Polish Transplantation Society 19.30 21.00 Gala dinner (extra paid participation) 21.00 HLA 4 transplant concert (additional payment) SATURDAY, 14 OCTOBER 2017

ROOM 1 ROOM 2 ROOM 3 ROOM 4 09.00 10.30 Plenary session III: Advances in immunosuppressive therapy Head: Marta Wawrzynowicz-Syczewska, Krzysztof Mucha, Marian Klinger 1. 9.00 9.25 Optimisation of immunosuppressive therapy after liver transplant for hepatocellular carcinoma Piotr Małkowski (Warszawa) 2. 9.25 9.50 Immunosuppression in patients with decreased glomerular filtration receiving organ transplant other than kidney Marian Klinger (Wrocław) 3. 9.50 10.15 Influence of intrapatient variability in tacrolimus exposure on long-term survival after solid organ Denis Hesselink (Rotterdam) 4. 10.15 10.30 Discussion Annals of Head: Krzysztof Zieniewicz, Wojciech Lisik, Marek Graczyński 1. 9.00 9.20 History of Annals of Transplantation Wojciech Lisik 2. 9.20 9.40 How to devise a clinical study? Maciej Kosieradzki 3. 9.40 10.00 How to prepare a manuscript for a peer-reviewed journal? Marek Graczyński 4. 10.00 10.20 Progress in liver Nigel Heaton (Londyn) 5. 10.20 10.30 Discussion Problems in transplant pathology Head: Barbara Górnicka, Bogna Ziarkiewicz- Wróblewska, Agnieszka Perkowska-Ptasińska 1. 9.00 9.15 Pitfalls of frozen section diagnostics in donor and recipient tissue directly before Beata Gierej 2. 9.15 9.35 Liver rejection current guidelines for morphological evaluation Barbara Górnicka 3. 9.35 9.55 Kidney rejection current guidelines for morphological evaluation Agnieszka Perkowska-Ptasińska 4. 9.55 10.15 PTLD an everimportant issue in organ transplant recipients Bogna Ziarkiewicz-Wróblewska Joint session with the Polish Society of Tissue and Cell Banking: Tissue and cell biobanking Head: Henryk Bursig, Artur Kamiński 1. 9.00 9.20 Biotechnology in reconstruction of knee joint. Konrad Słynarski 2. 9.20 09.30 Use of in vitro-cultured skin components in the treatment of severely ill patients Agnieszka Klama-Baryła (Siemianowice Śląskie) 3. 9.30 09.40 New use of allogenic bone blocks sinus lift open procedure Kornel Krasny 4. 9.40 09.50 Use of cryopreserved allogeneic pericardium in the surgery for congenital heart defects in children Mariusz Birbach 5. 10.15 10.25 Disseminated Kaposi sarcoma after liver transplant presentation of the first ever case of HIV-infected patient in Poland Michał Mazurkiewicz 6. 10.25 10.30 Discussion 5. 9.50 10.00 Influence of cryopreservation on structural, chemical and immunoenzymatic properties of aortic valves allografts Roman Pfitzner (Cracow) 6. 10.00 10.10 Should tissue establishments (TEs) have routine access to clinical outcome data? - a cooperation between the TE and end-users based on early outcomes of radiation-sterilized frozen amnion in 2012-2016 Izabela Uhrynowska-Tyszkiewicz

7. 10.10 10.20 Autologous chondrocyte transplant in the treatment of articular cartilage damage own experience Henryk Bursig (Katowice) 8. 10.20 10.30 Tissue preparation for DSAEK - the new procedure in the Lublin Eye Bank Grażyna Płaszczewska (Lublin) 10.30 11.00 Coffee break 11.00 12.30 Liver part II Head: Marek Pacholczyk, Paweł Chudoba, Samir Zeair 1. 11.00 11.20 Liver malignancy as indication for liver transplant world trends Kidney part II Head: Władysław Sułowicz, Marek Ostrowski, Magdalena Krajewska 1. 11.00 11.20 Atypical haemolyticuraemic syndrome and Thoracic organ part II Head: Tomasz Grodzki, Wojciech Dyszkiewicz, Jacek Wojarski 1. 11.00 11.20 Update on EVLP (Ex Vivo Lung Perfusion) and OCS (Organ Caring System) VCA session: Vascularised composite grafts Head: Adam Maciejewski, Dorota Kamińska, Jerzy Jabłecki 1. 11.00 11.20 Antalya experience in VCA Marek Pacholczyk Ryszard Grenda Gregor Warnecke (Hanower) Ozlenen Ozkan (Antalya) 2. 11.20 11.35 Late tumour recurrence after liver transplant Krzysztof Mucha 3. 11.35 11.50 Does DAA therapy influence the liver transplant waiting list? Olga Tronina 4. 11.50 12.05 Management of HCC patients awaiting liver transplant Robert Król (Katowice) 5. 12.05 12.15 Restrictive fluid therapy and intraoperative blood loss under liver. A retrospective study Jan Pluta 6. 12.15 12.30 Discussion 2. 11.20 11.40 Individualisation of post-transplant immunosuppressive therapy Marian Klinger (Wrocław) 3. 11.40 12.00 Graft function and cardiovascular complications therapeutic implications Jolanta Małyszko (Białystok) 4. 12.00 12.20 Current aspects of diagnosing and management of antibody-mediated rejection Magdalena Durlik 5. 12.20 12.30 Discussion 2. 11.20 11.35 Pitfalls and problems in LTx Bartosz Kubisa (Szczecin) 3. 11.35 11.50 Cystic fibrosis and LTx Jacek Wojarski (Zabrze) 4. 11.50 12.05 New centre, old problems beginnings of the lung centre in Poznań Cezary Piwkowski (Poznań) 5. 12.05 12.20 Current trends in management of LTx recipients Maria Piotrowska (Szczecin) 6. 12.20 12.30 Discussion 2. 11.20 11.30 Face allograft in experience from the Gliwice centre Łukasz Krakowczyk (Gliwice) 3. 11.30 11.40 Composite allografting of the neck organs own experience Adam Maciejewski (Gliwice) 4. 11.40 11.50 Alternatives for classic reconstructive microsurgery in allo Maciej Grajek (Gliwice) 5. 11.50 12.00 First ever upper limb allotransplant in patient with arm aplasia Adam Domanasiewicz (Wrocław)

6. 12.00 12.10 Ten-year experience in upper limb Jerzy Jabłecki (Trzebnica) 7. 12.10 12.20 So like but still unlike rejection and immunosuppressive therapy in upper limb allo Dorota Kamińska (Wrocław) 12.30 13.00 Break with lunchboxes (lunchboxes will be handed out at the catering) 13.00 14.45 Plenary session IV: Advances in Polish transplantology Head: Piotr Przybyłowski, Krzysztof Zieniewicz, Marian Zembala Session moderators: Lech Cierpka, Tomasz Grodzki, Mariusz Kuśmierczyk 1. 13.00 13.03 Introduction Krzysztof Zieniewicz 2. 13.03 13.18 Where are we in Polish transplantology? Achievements and future prospects Leszek Pączek 3. 13.18 13.26 Composite tissue Adam Maciejewski (Gliwice) 4. 13.26 13.34 Paediatric organ in Poland Piotr Kaliciński 5. 13.34 13.42 Corneal transplant in adults and children in Poland Edward Wylęgała (Katowice)

6. 13.42 13.50 Cardiac transplant in adults and children and mechanic circulatory support. New challenges and new commitments for patients, caregivers and stakeholders Marian Zembala (Zabrze) 7. 13.50 13.58 Lung for cystic fibrosis in Poland. New applications of the extracorporeal lung perfusion system Jacek Wojarski (Zabrze) 8. 13.58 14.06 Advances in haematopoietic stem cell Wiesław Jędrzejczak 9. 14.06 14.14 Advances in liver in adults Waldemar Patkowski 10. 14.14 14.22 Advances in pancreas challenges in the era of intelligent insulin pumps Marek Durlik 11. 14.22 14.30 Tissue banking in Poland importance and development Artur Kamiński 12. 14.30 14.45 Discussion 14.45 15.00 Congress closing Head: Piotr Przybyłowski, Krzysztof Zieniewicz