P-gp inhibition (11-Me-Leu)-Cyclosporin A 1 1,2,3,4-Tetrahydro-1-methyl-6,7-isoquinolinediol 0 1,2,3,4-Tetrahydro-6,7-dimethoxy-isoquinoline 0

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1 ligand P-gp inhibition (11-Me-Leu)-Cyclosporin A 1 1,2,3,4-Tetrahydro-1-methyl-6,7-isoquinolinediol 0 1,2,3,4-Tetrahydro-6,7-dimethoxy-isoquinoline 0 1,2,3,4-Tetrahydro-isoquinoline 0 1,3,5-Triazacycloheptane 4b 1 1,3,5-Triazacycloheptane 4c 1 1,3,5-Triazacycloheptane 5b 1 1,3,5-Triazacycloheptane 5c 1 1,3,5-Triazacycloheptane 5d 1 1,3,5-Triazacycloheptane 6b 1 1,3,5-Triazacycloheptane 6c 1 1-(3-methoxyphenyl)-N,N-dimethylmethanamine 0 1-(4-chlorbenzhydryl)piperazine 0 1-Benzyl-3-pyrroline 0 1-Benzylimidazole 0 1-Phenethylpiperidine 0 1-Phenylpiperazine 0 11-Deoxycortisol 1 14-Benzoylyohimbine 1 16-Dehydroprogesterone 1 16-Methylprogesterone 1 17-Hydroxypregnenolone 0 17-Hydroxyprogesterone 1 2,2'-Diphenylethylamine 0 2,4,6,8-Tetradiethano 0 2,4,6,8-Tetramopholin 0 2,4,6,8-Tetrapiperidy 0 2,4,6-Trimorpholinepy 0 2,4,8-Trimorpholinepy 0 2-Benzylpyridine 0 2-Chloro-10-[2-(dimethylamino)ethyl] phenothiazine 1 2-Chloro-10-[4-(dimethylamino)butyl] phenothiazine 1 2-Chloroimipramine 1 2-Oxazolidinone 0 3'-4'-Dichlorobenzamil 0 3,8-Dihydroxychlorpromazine 0 3-Methyl choroquine 1 4,8-Dipiperidyl-2,6-D 0 4,8-Dipiperidyl-2,6-M 0 4,8-Dipiperidyl-Dimet 0 4-(2-Dimethylamino)ethyl)morpholine 0 4-Androstene-3,17-dione 1 4-Hydroxytamoxifen 1 4-Hydroxytoremifene 1 4-Iodotamoxifen 1 4-beta-Phorbol 12,13-dibutyrate 1 4-beta-Phorbol 13-acetate 0 4-beta-Phorbol 13-butyrate 0 5-(N,N-hexamethylene)amiloride 0

2 5-(N-Methyl-N-isobutyl)amiloride 0 5-N-acetyl-8-demethylardeemin 1 5-N-acetylardeemin 1 5-[N-Methyl-N-(tert-butyl)]-amiloride 0 6-Phenyl-2,4,7-pterid 0 7,8-Dihydroxychlorpromazine 0 7-Hydroxychlorpromazine 0 AF AG AG AG AHC-52 1 AHR AHR AHR AN AY Acapriazine 0 Acebutolol 0 Acecainide 0 Acepromazine 1 Aceprometazine 1 Acetophenazine 1 Acridine 0 Acridone-4-carboxamide 22 1 Acridone-4-carboxamide 23 1 Acridone-4-carboxamide 24 1 Acridone-4-carboxamide 28 1 Acridone-4-carboxamide 29 1 Acridone-4-carboxamide 30 1 Acridone-4-carboxamide 31 1 Acridone-4-carboxamide 32 1 Acridone-4-carboxamide 36 1 Acridone-4-carboxamide 39 1 Acridone-4-carboxamide 43 1 Acridone-4-carboxamide 44 1 Acridone-4-carboxamide 47 1 Acridone-4-carboxamide 48 1 Acridone-4-carboxamide 49 1 Acridone-4-carboxamide 50 1 Acridone-4-carboxamide 51 1 Acridone-4-carboxamide 52 1 Acridone-4-carboxamide 53 1 Acridone-4-carboxamide 54 1 Acridone-4-carboxamide 55 1 Acridone-4-carboxamide 59 1 Acridone-4-carboxamide 60 1 Acridone-4-carboxamide 61 1 Acridone-4-carboxamide 64 1 Acridone-4-carboxamide 65 1

3 Acridone-4-carboxamide 66 1 Acridone-4-carboxamide 67 1 Acridone-4-carboxamide 68 1 Acridone-4-carboxamide 69 1 Acridone-4-carboxamide 70 1 Acridone-4-carboxamide 71 1 Acridone-4-carboxamide 72 1 Acridone-4-carboxamide 73 1 Acridone-4-carboxamide 74 1 Acridone-4-carboxamide 75 1 Acridone-4-carboxamide 76 1 Acridone-4-carboxamide 77 1 Acridone-4-carboxamide 78 1 Acridone-4-carboxamide 79 1 Acridone-4-carboxamide 80 1 Acridone-4-carboxamide 81 1 Acridone-4-carboxamide 82 1 Acridone-4-carboxamide 83 1 Acridone-4-carboxamide 85 1 Acrivastine 0 Actinomycin D 0 Adiphenine 0 Aldicarb 0 Aldoxycarb 0 Aldrich Almitrine 1 Alpertine 1 Alpha-Tocopherol 0 Alprenolol 1 Alverine Amantadine 0 Ambodryl 0 Amiloride 0 Aminocarb 0 Aminopentamide 0 Amiodarone 1 Amitriptyline 1 Amlodipine 1 Amodiaquin 0 Amotriphene 1 Amoxapine 1 Amoxecaine 0 Amperozide 1 Amphotericin B 0 Amprenavir 1 Androstenedione 1 Androsterone 1 Antazoline 0 Antenolol 0 Antipyrine 0

4 Apomorphine 0 Aprindine 1 Ascorbic acid 0 Asocainol 1 Astemizole 1 Atorvastatin (methyl ester) 1 Atorvastatin lactone 1 Atrazine 0 Atropine 0 Aureobasidin A (ABA) 1 Azaclorazine 1 Azaconazole 0 Azaperone 0 Azelastine 1 Azidopine 1 Azidoprocainamide methoiodide 0 Azipramine 1 B B669 1 B BIBW 22 1 BW 1019W91 1 BW 1136U89 1 BW 1288U89 1 BW 1351W91 1 BW 1379W91 1 BW 565C81 1 Bamipine 0 Barnidipine 1 Befuraline 0 Benactyzine 0 Bencyclane 0 Benidipine 1 Benzathine 1 Benzmalecene 0 Benzofuran derivative 2a 0 Benzofuran derivative 2c 1 Benzofuran derivative 2d 1 Benzofuran derivative 2e 1 Benzofuran derivative 2f 1 Benzquinamide 0 Benztropine 1 Bepridil 1 Berberine 0 Bevantolol 1 Bifonazole 1 Biperiden 0 Biphenamine 0 Biricodar 1 Bisobrin 0

5 Bleomycin A2 0 Boldine 0 Boxidine 0 Bromocriptine 1 Brompheniramine 0 Bryostatin 0 Bucainide 1 Buclizine 1 Budipine Buflomedil 0 Bufuralol 1 Bunaftine 1 Buspirone 1 Butalamine 0 Butaperazine 1 Buterizine 1 Butethamate 0 CP CP CP CP CP CP CP CP CP Calcimycin 0 Calphostin C 1 Captodiame Carbamazepine 0 Carbaryl 0 Carbinoxamine 1 Carbiphene 1 Carnitine 0 Caroverine 1 Carphenazine 1 Carvedilol 1 Carvedilol metabolite M2 0 Carvedilol metabolite M4 0 Carvedilol metabolite M5 0 Catharanthine 1 Cefoperazone 0 Cefotetan 0 Ceftazidime 0 Celiprolol 0 Cepharanthine 1 Cephradine 0 Cetiedil 1 Cetrizine 0 Chelerythrine 0

6 Chlophedianol 0 Chloracyzine 1 Chlorbenzoxamine 1 Chlorcyclizine 0 Chlorogenic acid 0 Chloropyramine 0 Chloroquine 0 Chlorpheniramine 0 Chlorphenoxamine Chlorproethazine 1 Chlorpromazine 1 Chlorprothixene 1 Chlorzoxazone 0 Chromonar Cimetidine 0 Cinchonidine 1 Cinepaxadil 1 Cinepazet 0 Cinepazic acid 0 Cinepazide 0 Cinnarizine 1 Cinprazole 1 Cinpropazide 0 Cintriamide 0 Cinuperone 1 Ciprofloxacin 0 Citalopram 0 Citatepine 1 Citenamide 0 Clamoxyquin 0 Clanobutin 0 Clebopride 0 Clemastine 1 Clemizole 1 Cletoquine 0 Clobutinol 0 Clocinizine 1 Clomestrone 0 Clomiphene 0 Clomipramine 1 Clonidine 0 Clopenthixol 1 Cloperastine 1 Clopimozide 1 Clopipazan 1 Clothiapine 1 Clothixamide 1 Clotrimazole 1 Colchicine 0 Colforsin 1

7 Coralyne 0 Corticosterone 0 Cortisone 0 Corynanthine 1 Coumaphos 1 Cryptophycin 1 Cyclobenzaprine 1 Cyclofenazine 1 Cyclopeptolide(1) 0 Cyclopeptolide(11) 0 Cyclopeptolide(12a) 1 Cyclopeptolide(12b) 1 Cyclopeptolide(15a) 1 Cyclopeptolide(15b) 1 Cyclopeptolide(16a) 1 Cyclopeptolide(16c) 1 Cyclopeptolide(16h) 1 Cyclopeptolide(18) 1 Cyclopeptolide(19) 0 Cyclopeptolide(2a) 1 Cyclopeptolide(2c) 1 Cyclopeptolide(2f) 1 Cyclopeptolide(3a) 1 Cyclopeptolide(3c) 1 Cyclopeptolide(3f) 1 Cyclopeptolide(3g) 1 Cyclopeptolide(3h) 1 Cyclopeptolide(3i) 1 Cyclopeptolide(3j) 1 Cyclopeptolide(3l) 1 Cyclopeptolide(3n) 1 Cyclopeptolide(4) 1 Cyclopeptolide(7) 1 Cyclopeptolide(8) 1 Cyclopeptolide(9) 1 Cyclophenazine 1 Cyclosporin A 1 Cyclosporin C 1 Cyclosporin G 1 Cypermethrin 1 Cyproheptadine 1 Cytochalasin A 0 Cytochalasin C 0 Cytochalasin D 0 Cytochalasin E 1 Cytochalasin H 0 Cytochalasin J 0 D490 1 D525 1 D528 0

8 D557 1 D559 1 D595 1 D784 1 D894 1 DDE 0 DDT 0 DHP DMDP 1 DPDPE 0 Dagapamil 1 Danitracen 0 Dapiprazole 0 Darodipine 1 Debrisoquin 0 Dehydroemetine 0 Delavirdine 1 Delfantrine 0 Deltorphin II 0 Denzimol 0 Deoxycorticosterone 1 Desethylamiodarone 1 Desipramine 1 Desmethoxyyangonin 1 Desmethylazelastine 1 Desmethylchlorpromazine 0 Desmethylcitalopram 0 Desmethylsertraline 1 Devapamil 1 Dexamethasone 0 Dexniguldipine 1 Dialifos 0 Dibenzylamine 0 Dibozan 0 Dibucaine 1 Dicapthon 1 Diclofensine 0 Didesmethylchlorpromzine 0 Diethylaniline 0 Diethylstilbestrol 1 Difloxacin 0 Difluanine 1 Digoxin 0 Dihydroergotamine 0 Dihydromethysticin 1 Dihydropyridine DP11 1 Dihydropyridine DP5 1 Dihydropyridine DP6 1 Dihydropyridine DP7 1 Dihydropyridine DP9 1

9 Dihydropyrroloquinoline series 14 0 Dihydropyrroloquinoline series 27 1 Diisopromine Dilazep 1 Diltiazem 1 Dimethindene 1 Diosmetin 0 Diosmin 0 Diphenamid 0 Diphenazoline 0 Diphenidol 1 Diphenylpyraline 1 Disopyramide 0 Dixyrazine 1 Dobutamine 0 Doconazole 1 Domperidone 0 Doxapram 1 Doxazosin Doxepine 1 Doxorubicin 0 Doxylamine 0 Drobuline 1 Drofenine 0 Droloxifen 0 Droprenilamine 1 Droproizine 0 Duoperone 1 EKI Ebastine 1 Econazole 0 Efonidipine 1 Eletriptan 0 Eltoprazine 0 Emepronium 0 Emetine 0 Emopamil 1 Enciprazine 1 Endosulfan 1 Enilconazole 0 Enoxacin 0 Epinephrine 0 Eprazinone 1 Eprozinol 1 Equilenine 0 Equilin 0 Ergocristine 1 Ergocryptine 1 Ergonovine 0 Ergotamine 1

10 Erythromycin 1 Estradiol 0 Estriol 0 Estrone 0 Etafenone 1 Ethylbenztropine 1 Ethylbenzylaniline 0 Etifelmin 0 Etodroxizine Etolotifene 1 Etomidoline 1 Etoposide 0 Euphodendroidin A 1 Euphodendroidin B 1 Euphodendroidin C 1 Euphodendroidin D 1 Euphodendroidin E 1 Euphodendroidin G 1 Euphodendroidin H 1 Euphodendroidin I 1 Euprocin 1 Falipamil 0 Famciclovir 0 Farnesyl analog AFCA 1 Farnesyl analog AFCMA 1 Farnesyl analog AFCME 1 Febuverine 1 Felodipine 1 Fenbutrazate 1 Fendiline 1 Fenoctimine 0 Fenoterol 0 Fenoxedil 1 Fenpipramide 0 Fenpiverinium 0 Fenticonazole 1 Fenvalerate 0 Fexofenadine 0 Filipin 0 Fisetin 0 Flavonoid ID 13 1 Flavonoid ID 21 0 Flavonoid ID 22 0 Flavonoid ID 23 0 Flavonoid ID 24 0 Flavonoid ID 37 1 Flavonoid ID 38 0 Fleroxacin 0 Flesinoxan 0 Flezelastine 1

11 Flordipine 1 Fluanisone 1 Fluazifop-butyl 0 Fluconazole 0 Flumazenil 0 Flunarizine 1 Fluoxetine 1 Fluperamide 1 Fluperlapine 1 Fluphenazine 1 Flurazepam 1 Fluspirilene 1 Fluvoxamine 1 GF GGCME 1 GW Gallopamil 1 Gamfexine 0 Geldanamycin 1 Geldanamycin 17-AAG 1 Gepirone 0 Ginsenoside Rg3 1 Ginsenoside Rh2 1 Glaucine 1 Gramine 0 Guanabenz 0 Guanfacine 0 H-7 0 H-89 1 HA HDL Halopemide 1 Haloperidol 1 Hepzidine 1 Hexadiline 0 Hexobendine 1 Hexoprenaline 0 Histapyrrodine 0 Hoechst Homochlorocyclizine 0 Homofenazine Homoveratrylamine 0 Hoquizil 0 Hydramethylnon 1 Hydrastine 0 Hydrocotarnine 0 Hydromorphone 0 Hydroxyzine 1 Hyperforin 0 Idarubicin 1

12 Imatinib 1 Imiclopazine 0 Imipramine 1 Imolamine 0 Imoxiterol 0 Indinavir 0 Indomethacin 0 Isoconazole 1 Isoniazid 0 Isopromethazine 1 Isoxsuprine 0 Isradipine 1 Itraconazole Ivermectin Bla 1 Jatrophane diterpene(7) 1 Jatrophane diterpenoid(1) 1 Jatrophane diterpenoid(10) 1 Jatrophane diterpenoid(11) 1 Jatrophane diterpenoid(12) 1 Jatrophane diterpenoid(13) 1 Jatrophane diterpenoid(14) 1 Jatrophane diterpenoid(15) 1 Jatrophane diterpenoid(16) 1 Jatrophane diterpenoid(2) 1 Jatrophane diterpenoid(3) 1 Jatrophane diterpenoid(5) 1 Jatrophane diterpenoid(6) 1 Jatrophane diterpenoid(8) 1 Jatrophane diterpenoid(9) 1 K02 1 Keoxifene 0 Ketamine 0 Ketoconazole 1 Ketotifen 1 LR LU LU LU LU LU LU LU LY LY LY LY LY LY Labetalol 0 Laudanosine 1

13 Laudanosoline 0 Lenperone 1 Levodopa 0 Levophacetoperane 0 Lidocaine 0 Lidoflazine 1 Linadryl 1 Lindane 0 Lobeline 1 Lombazole Loperamide 1 Lopinavir 1 Loratadine 1 Lorcainide 1 Losartan 0 Lovastatin acid 0 Lovastatin lactone 1 Loxapine 1 Luteolin 0 Luteolin-4'-O-glucoside 0 MA MA MA MA MA MA MA MA MA MA MDL 6792 MDL MDL8917V 1 MDR reversal agent 15h 1 MDR reversal agent 15i 1 MDR reversal agent 15m 1 MDR reversal agent 15o 1 MDR reversal agent 15u 1 MDR reversal agent 15x 1 MDR reversal agent 28a 1 MDR reversal agent 28c 1 MDR reversal agent 35a 1 MDR reversal agent 35d 1 MDR reversal agent 37b 1 MER37 1 MK MM36 1 MS Macbecin II 1 Manidipine 1

14 Mannitol 0 Maprotiline 1 Maroxepine 0 Mebendazole 1 Mebeverine 1 Meclizine 1 Mecloxamine 0 Medroxyprogesterone 1 Medroxyprogesterone acetate 1 Mefloquine 1 Megestrol Acetate 1 Meglitinide 0 Memotine 0 Mephentermine 0 Mephenytoin 0 Mepramidil 1 Meprobamate 0 Mequitazine 1 Mesoridazine 1 Mesuprine 0 Metergoline 1 Methadone 1 Methaphenilene 0 Methdilazine 0 Methixene 0 Methomyl 0 Methotrimeprazine 1 Methoxychlor 0 Methoxypromazine Methyl Cellosolve Acetate 0 Methylamine 0 Methysergide 0 Methysticin 1 Metiapine 1 Metoclopramide 0 Metofenazate 1 Metopimazine 0 Metoprolol 0 Metoserpate 1 Metoxepin 1 Mevinphos 0 Mexilitene 0 Mezilamine 0 Mianserin 0 Mibefradil 1 Miconazole 0 Midazolam 1 Mifepristone (RU486) 1 Milenperone 1 Milipertine 1

15 Mioflazine 1 Mirex 0 Mitomycin C 0 Mitoxantrone 0 Mixidine 0 Moclobemide 0 Monensin 1 Mopidamol 0 Morin 0 Morphine 0 Motracetam 0 Moxapridine 1 N,N'-Diphenyl-p-phenylenediamine 0 N,N'-dibenzylethylene diamine 0 N,N-Bis(alkanol)amine aryl ester analog 21 1 N,N-Bis(alkanol)amine aryl ester analog 5 0 N,N-Bis(alkanol)amine aryl ester analog 6 1 N,N-Bis(alkanol)amine aryl ester analog 8 1 N,N-Bis(alkanol)amine aryl ester analog 9 1 N,N-Dimethylbenzylamine 0 N,N-bis(cyclohexanol)amine aryl ester (3) 1 N,N-bis(cyclohexanol)amine aryl ester (4) 1 N,N-bis-arylalkylamine derivative(1) 1 N,N-bis-arylalkylamine derivative(2) 1 N,N-diethylcyclohexylamine 0 N-Benzylbenzamide 0 N-Methyl-gallopamil 0 N-Norlaudanosine 1 N-Norlaudanosoline 0 N-Phenyl-1-naphthylamine 0 N-Phenyl-2-naphthylamine 0 N-acetyl-daunorubicin 1 N-acyloxy-1,4-dihydropyridine(10) 1 N-acyloxy-1,4-dihydropyridine(5) 1 N-acyloxy-1,4-dihydropyridine(6) 1 N-acyloxy-1,4-dihydropyridine(7) 1 N-acyloxy-1,4-dihydropyridine(8) 1 N-acyloxy-1,4-dihydropyridine(9) 1 N-desmethyl-toremifene 1 N-desmethyl-venlafaxine 1 N-desmethyltamoxifen 1 N-trialkylglycine N31214C 1 NK NK NSC NSC NSC NSC NSC NSC

16 NSC NSC NSC NSC NSC NSC NSC NSC NSC NSC NSC NSC NSC NSC NSC NSC NSC NSC NSC Nafcillin 0 Nafiverine 1 Nafoxidine 1 Naftifine 0 Naftopidil 1 Naftoxate 1 Nalbuphine 0 Naloxone 0 Naltrexone 0 Naltrindole 0 Nefazodone 1 Nelfinavir 1 Neostigmine 0 Nicardipine 1 Nicergoline 1 Nifedipine 1 Nilprazole 1 Niludipine 1 Nimodipine 1 Nisoldipine 1 Nitrazepam 0 Nitrendipine 1 Nitromifene 1 Nobiletin 1 Nomifensine 0 Nordazepam 0 Norfloxacin 0 Norfluxetine 1 Norgallopamil 1 Nortriptylene 1 Norverapamil 1

17 Noscapine 1 Nuclotixene 0 Nylidrin 0 O-desmethyl-venlafaxine 0 OBF OBF OBF OC OL-57 1 Ofloxacin 0 Oleanolic acid 0 Olivomycin A 0 Omeprazole 1 Omeprazole sulfone 0 Omoconazole 0 Opipramol 0 Opromazine 1 Orconazole Oxamarin 0 Oxatomide 1 Oxiconazole 0 Oxolinic acid 0 Oxprenolol 0 Oxybutynin 1 Oxyfedrine 0 Oxypendyl 0 Oxyperomide 0 Oxypertine 1 PAK-1 1 PAK PAK-8 0 PGP Palmitoylcartinine 0 Papaverine 0 Paraquat 0 Parathion-methyl 1 Parconazole 0 Paroxetine 1 Pefloxacin 0 Penfluridol 1 Pentachlorophenol 0 Pentazocine 1 Peptoid 1 1 Peptoid 2 1 Peradoxime 1 Perafensine 0 Perazine Perhexilline 0 Perimetazine 1 Perlapine 1

18 Perphenazine 1 Phenethylamine 0 Pheniramine 0 Phenoxazine ID 11 1 Phenoxazine ID 12 1 Phenoxazine ID 15 0 Phenoxazine ID 18 1 Phenoxazine ID 2 1 Phenoxazine ID 3 1 Phenoxazine ID 4 1 Phenoxazine ID 5 1 Phenylamil 1 Phenyltoloxamine 0 Phenytoin 0 Phorbol 0 Phosmet 0 Physostigmine 1 Pifarnine 1 Piflutixol 1 Pimethixene 1 Pimozide 1 Pinafide 0 Pinoxepine 1 Pipamperone 1 Pipemidic Acid 0 Piperacetazine Piperamide 0 Piperdimerine A 1 Piperine 1 Pipoxizine 1 Pipoxolan 0 Pirenzepine 0 Pirohenptine 1 Piromidic Acid 0 Pirprofen 0 Pizotyline 1 Pramiverin 0 Pravastatin 0 Prazosin 1 Predifine 1 Pregnanedione 1 Prenoverine 0 Prenoxidiazine 1 Prenylamine 1 Primaquine 0 Primidolol 0 Prinixic acid 0 Pristinamycin IA 1 Proadifen 1 Prochlorperazine 1

19 Procyclidine 1 Prodipine Progabide 1 Progesterone 1 Promazine 0 Promethazine 1 Propafenone 1 Propafenone derivative 1b 1 Propafenone derivative 1c 1 Propafenone derivative 1e 1 Propafenone derivative 1f 1 Propafenone derivative 1g 1 Propafenone derivative 1i 1 Propafenone derivative 1k 1 Propafenone derivative GP01 1 Propafenone derivative GP02 1 Propafenone derivative GP03 0 Propafenone derivative GP05 1 Propafenone derivative GP07 0 Propafenone derivative GP10 0 Propafenone derivative GP134 1 Propafenone derivative GP155 1 Propafenone derivative GP159 1 Propafenone derivative GP163 1 Propafenone derivative GP164 1 Propafenone derivative GP17 0 Propafenone derivative GP240 1 Propafenone derivative GP29 1 Propafenone derivative GP31 1 Propafenone derivative GP339 1 Propafenone derivative GP358 1 Propafenone derivative GP359 1 Propafenone derivative GP360 1 Propafenone derivative GP366 1 Propafenone derivative GP381 1 Propafenone derivative GP388 1 Propafenone derivative GP389 0 Propafenone derivative GP46 0 Propafenone derivative GP57 1 Propafenone derivative GP62 1 Propafenone derivative GP88 1 Propafenone derivative GP90 1 Propafenone derivative ID 16 1 Propafenone derivative ID 17 1 Propafenone derivative ID 19 1 Propafenone derivative ID 20 1 Propafenone derivative ID 21 1 Propafenone derivative ID 22 1 Propafenone derivative ID 23 1 Propafenone derivative ID 24 1

20 Propafenone derivative ID 28 1 Propafenone derivative ID 29 1 Propafenone derivative ID 36 1 Propafenone derivative ID 37 1 Propafenone derivative ID 38 1 Propafenone derivative ID 39 1 Propafenone derivative ID 40 1 Propafenone derivative ID 7b 1 Propantheline 0 Propenzolate 1 Propericiazine 0 Propiconazole 0 Propoxur 0 Propoxyphene 1 Propranolol 1 Prothipendyl 0 Protokylol 0 Protriptyline 1 Proxazole 0 Prozapine Purine analog ID 17 1 Purine analog ID 18 1 Purine analog ID 24 1 Purine analog ID 26 1 Purine analog ID 28 1 Purine analog ID 3 1 Purine analog ID 32 1 Purine analog ID 4 1 Purine analog ID 5 1 Purine analog ID 7 1 Purine analog ID 8 1 Purine analog ID 9 1 Puromycin 0 Pyrathiazine 1 Pyrilamine 0 Quinacrine 1 Quinazosin 0 Quinidine 1 Quinupramine 1 Quipazine 0 R R R R49960 R59022 R RA RA-14 1 RA RA-159 0

21 RA RA-17 0 RA RA RA-19 1 RA RA-24 1 RA-3 0 RA-4 0 RA-8 1 RA-83 0 RE RE-28 1 RE-34 0 RE-38 1 RE-57 1 RE-61 1 RE-62 1 RE-66 0 RXRA-160 RXRA RXRA-69 1 RXRE RXRE-61 0 RXRE-62 0 RXRE-63 1 Racefemine 1 Racemethorphan 0 Ranitidine 0 Razinodil 1 Reboxetine 1 Rescinnamine 1 Reserpic acid 0 Reserpine 1 Revenast 1 Reversin Reversin Rhoifolin 0 Rifampin 1 Rifamycin B 0 Rifamycin SV 0 Rilapine 1 Risperidone 1 Ritodrine 0 Ritonavir 1 Ro Ro Ro Ro Ro

22 Ro Ro Ro Ro Rolitetracycline 0 Ropitoin 1 Ropizine 1 Roxithromycin 1 Rythmol 1 S S-Farnesylcysteine 0 S S S S S S S S S S S S S SCH SDZ-PSC SKF SKF-3301 SNC SPS SPS SPS SPS SPS SPS SPS SPS SPS SPS SPS SPS SPS SPS SPS SPS SPS SPS SPS SPS SPS

23 SPS SPS SPS SPS 1847 SPS SPS SPS SPS SPS SPS SZ48 1 Safingol 0 Salmeterol Salverine 0 Saquinavir 1 Scopolamine 0 Secoverine 1 Selegiline 0 Selparazine 1 Sertraline 1 Sesquiterpene(1) 1 Sesquiterpene(11) 1 Sesquiterpene(12) 1 Sesquiterpene(13) 1 Sesquiterpene(14) 1 Sesquiterpene(8) 1 Setastine 1 Silybin 1 Simetride 1 Simvastatin acid 0 Sirolimus 1 Sitagliptin 0 Solanesol 0 Solypertine 1 Spasmadryl 0 Spiramide 1 Spirilene 1 Strophanthidin 0 Sulconazole 0 Sulfasalazine 0 Sulfinpyrazone 0 Sulforidazine 1 Suloctidil 0 Sumatriptan 0 Suramin 0 Syrosingopine 1 T13 1 TMB8 1 TPP 0 TRX-13 0

24 Tacrine 0 Tacrolimus 1 Talinolol 0 Tamoxifen 1 Tampramine 1 Tangeretin 1 Tefludazine 1 Telithromycin 1 Terbinafine 0 Terconazole 1 Terfenadine 1 Terodiline 1 Teroxalene 1 Testosterone 1 Tetrabenazine 0 Tetrahydroquinoline ID 2a 1 Tetrahydroquinoline ID 2b 1 Tetrahydroquinoline ID 2f 1 Tetrahydroquinoline ID 2g 1 Tetrahydroquinoline ID 3f 1 Tetrahydroquinoline ID 3g 1 Tetraphenylphosphonium 0 Thalicarpine 1 Thenaldine 0 Thenyldiamine 0 Thiethylperazine 1 Thioproperazine 1 Thioridazine 1 Thonzylamine 0 Tiapamil 1 Tiaramide 0 Tilorone 0 Tilozepine 1 Tioconazole 0 Tiodazosin 0 Tioperidone 1 Tiopropamine Tiprenolol 0 Tipropidil 0 Tixadil 0 Tolamolol 0 Tolnapersine 1 Tolpropamine Tolyporphin A 1 Toprilidine 1 Toremifene 1 Trazodone 1 Tretoquinol 0 Tri-n-butylmethylamminiun 0 Triazine derivative ID 11 1

25 Triazine derivative ID 12 1 Triazine derivative ID 15 1 Triazine derivative ID 16 1 Triazine derivative ID 17 1 Triazine derivative ID 18 1 Triazine derivative ID 20 1 Triazine derivative ID 21 1 Triazine derivative ID 22 1 Triazine derivative ID 23 1 Triazine derivative ID 24 1 Triazine derivative ID 25 1 Triazine derivative ID 26 1 Triazine derivative ID 30 1 Triazine derivative ID 32 1 Triazine derivative ID 33 1 Triazine derivative ID 34 1 Triazine derivative ID 35 1 Triazine derivative ID 36 1 Triazine derivative ID 37 1 Triazine derivative ID 38 1 Triazine derivative ID 39 1 Triazine derivative ID 40 1 Triazine derivative ID 42 1 Triazine derivative ID 44 1 Triazine derivative ID 45 1 Triazine derivative ID 46 1 Triazine derivative ID 47 1 Triazine derivative ID 54 1 Triazine derivative ID 57 1 Triazine derivative ID 6 1 Triazine derivative ID 7 1 Triazine derivative ID 8 1 Triazine derivative ID 9 1 Triazolam 0 Trifluoperazine 1 Trifluperidol 1 Triflupromazine 1 Triforine 0 Trihexyphenidyl 0 Trimazosin 0 Trimebutine 1 Trimeprazine 0 Trimethoprim 0 Trimetozine 0 Trimipramine 1 Triparanol 1 Tripelennamine 0 Triprolidine 1 Tropirine 1 Troxonium 0

26 Trypan blue 0 Tryptanmine 0 Tryptophan 0 Tubulzole 0 U U10520A 1 U11555A 0 U18666A 1 UCB UCB UCB-J028 0 UCB-L172 1 UCB-N101 1 Urapidil 0 Valinomycin 1 Vancomycin 0 Venlafaxine 0 Verapamil 1 Verapamil analogue(19) 1 Verapamil analogue(2) 1 Verapamil analogue(25) 1 Verapamil analogue(29) 1 Verapamil analogue(4) 1 Verapamil analogue(5) 1 Vetrabutine 1 Vinblastine 1 Vinclozolin 0 Vincristine 0 Vindoline 1 Vitamin A palmitate 0 W-12 0 W-13 0 W-7 0 W W Warfarin 0 XR XR Xenthiorate 0 Zimeldine 0 Zipeprol 1 Zolamine 0 Zolertine 0 Zolmitriptan 0 Zoloperone 0 Zolpidem 1 Zomepirac 0 cis-flupentixol 1 cis-thiothixene 1 o-nitropehenyl N,N-dimethylcarbamate 0

27 1-P-gp inhibitor 0-P-gp non-inhibitor tra